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5

US Approved Rx

2

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Primary Target

DNA polymerase alpha subunit

2

Ribonucleoside-diphosphate reductase M1 chain

2

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Approved

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5

1991

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Chronic lymphocytic leukemia

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Primary

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Southern Research Institute

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7

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7

EPA CompTox

7

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7

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Salts, Hydrates, Esters, etc.

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Search results for "fludarabine phosphate" in Reference Text / Citation (approximate match)

Showing 1 - 7 of 7 results

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FLUDARABINE

P2K93U8740

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Status:

US Approved Rx (2003)

First approved in 1991

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA polymerase alpha subunit

Ribonucleoside-diphosphate reductase M1 chain

Conditions:

Chronic lymphocytic leukemia

Fludarabine or fludarabine phosphate is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas). It is a purine analog, which interferes with DNA synthesis. Fludarabine phosphat...

e is a fluorinated nucleotide analog of the antiviral agent vidarabine, 9-β-D-arabinofuranosyladenine (ara-A), that is relatively resistant to deamination by adenosine deaminase. Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.

9-(3,5-DI-O-PHOSPHONO-.BETA.-D-ARABINOFURANOSYL)-2-FLUORO-9H-PURIN-6-AMINE

SV2Z8F240H

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

6-AMINO-9-(5-O-PHOSPHONO-.BETA.-D-ARABINOFURANOSYL)-9H-PURIN-2-OL

K7LQW14UZW

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

ISOGUANINE

E335PK4428

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

2-FLUOROADENINE

2C8H3H4EBG

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

2-ETHOXY-9-(5-O-PHOSPHONO-.BETA.-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE

3NX9M1B2ZV

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

FLUDARABINE PHOSPHATE

1X9VK9O1SC

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Status:

US Approved Rx (2003)

First approved in 1991

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA polymerase alpha subunit

Ribonucleoside-diphosphate reductase M1 chain

Conditions:

Chronic lymphocytic leukemia

Fludarabine or fludarabine phosphate is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas). It is a purine analog, which interferes with DNA synthesis. Fludarabine phosphat...

e is a fluorinated nucleotide analog of the antiviral agent vidarabine, 9-β-D-arabinofuranosyladenine (ara-A), that is relatively resistant to deamination by adenosine deaminase. Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.

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