FLUDARABINE PHOSPHATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H13FN5O7P
Molecular Weight	365.2117
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC(F)=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]3O

InChI

InChIKey=GIUYCYHIANZCFB-FJFJXFQQSA-N

InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H13FN5O7P
Molecular Weight	365.2117
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022137lbl.pdf

Fludarabine or fludarabine phosphate is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas). It is a purine analog, which interferes with DNA synthesis. Fludarabine phosphate is a fluorinated nucleotide analog of the antiviral agent vidarabine, 9-β-D-arabinofuranosyladenine (ara-A), that is relatively resistant to deamination by adenosine deaminase. Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA polymerase alpha subunit 9 Target ID: CHEMBL1828 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022137lbl.pdf	Inhibitor 8504
Ribonucleoside-diphosphate reductase M1 chain 4 Target ID: CHEMBL1830 Sources: https://www.ncbi.nlm.nih.gov/pubmed/?term=23115527	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chronic lymphocytic leukemia 59 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022137lbl.pdf	Primary		Approved 8583	FLUDARABINE PHOSPHATE Approved Use Fludarabine Phosphate Injection is indicated for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen. The safety and effectiveness of Fludarabine Phosphate Injection in previously untreated or non-refractory patients with CLL have not been established. Important Limitations Fludarabine Phosphate Injection should not be used in patients with severe renal impairment (creatinine clearance less than 30 mL/min/1.73 m2). Launch Date 2007

C_max

Value	Dose	Co-administered	Analyte	Population
4.28 μM EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/17211431	30 mg/m² single, intravenous dose: 30 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:		FLUDARABINE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
21.55 μM × h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/17211431	30 mg/m² single, intravenous dose: 30 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:		FLUDARABINE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
20 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020038s033lbl.pdf	25 mg/m² 1 times / day multiple, intravenous dose: 25 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:		FLUDARABINE plasma	Homo sapiens population: UNHEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN
8.9 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/17211431	30 mg/m² single, intravenous dose: 30 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:		FLUDARABINE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
100 mg/m2 1 times / day multiple, intravenous Highest studied dose Dose: 100 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 100 mg/m2, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/2428488	unhealthy, 32 years (range: 19-59 years) Health Status: unhealthy Age Group: 32 years (range: 19-59 years) Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/2428488	Other AEs: Leukopenia... Other AEs: Leukopenia (2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/2428488
40 mg/m2 1 times / day steady, intravenous MTD Dose: 40 mg/m2, 1 times / day Route: intravenous Route: steady Dose: 40 mg/m2, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/2428488	unhealthy, 32 years (range: 19-59 years) Health Status: unhealthy Age Group: 32 years (range: 19-59 years) Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/2428488	Sources: https://pubmed.ncbi.nlm.nih.gov/2428488
20 mg/m2 1 times / day multiple, intravenous MTD Dose: 20 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 20 mg/m2, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/2452888	unhealthy, 55 years (range: 26-78 years) Health Status: unhealthy Age Group: 55 years (range: 26-78 years) Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/2452888	Sources: https://pubmed.ncbi.nlm.nih.gov/2452888
45 mg/m2 1 times / day multiple, intravenous Dose: 45 mg/m2, 1 times / day Route: intravenous Route: multiple Dose: 45 mg/m2, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/2452888	unhealthy, 55 years (range: 26-78 years) Health Status: unhealthy Age Group: 55 years (range: 26-78 years) Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/2452888	DLT: Myelosuppression... Dose limiting toxicities: Myelosuppression (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/2452888
40 mg/m2 1 times / day steady, oral Recommended Dose: 40 mg/m2, 1 times / day Route: oral Route: steady Dose: 40 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_MedR.pdf	unhealthy, 64 years (range: 30-75 years) Health Status: unhealthy Age Group: 64 years (range: 30-75 years) Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_MedR.pdf	Disc. AE: Thrombocytopenia, Anemia hemolytic autoimmune... AEs leading to discontinuation/dose reduction: Thrombocytopenia (1 patient) Anemia hemolytic autoimmune (3 patients) Pneumonia (1 patient) Anemia (1 patient) Foot drop (1 patient) Sepsis (1 patient) Bronchitis (1 patient) Rash (1 patient) Face edema (1 patient) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_MedR.pdf
25 mg/m2 1 times / day steady, intravenous Recommended Dose: 25 mg/m2, 1 times / day Route: intravenous Route: steady Dose: 25 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022137lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022137lbl.pdf	Other AEs: CNS toxicity, Hemolytic anemia... Other AEs: CNS toxicity Hemolytic anemia Pulmonary toxicity Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022137lbl.pdf
40 mg/m2 1 times / day steady, oral Recommended Dose: 40 mg/m2, 1 times / day Route: oral Route: steady Dose: 40 mg/m2, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022273lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022273lbl.pdf	Other AEs: CNS toxicity, Hemolytic anemia... Other AEs: CNS toxicity Hemolytic anemia Pulmonary toxicity Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022273lbl.pdf

AEs

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946 inhibitor 2252	inhibitor 2438	inhibitor 2507

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P-gp 1741 CYP1A2 2153 CYP2A6 879 CYP2C19 2057 CYP2E1 1060	P-gp 2052 CYP1A2 1197

Drug as perpetrator

Target	Modality	Activity
CYP1A2 2333	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=47 Page: 47.0	no
CYP2A6 911	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=47 Page: 47.0	no
CYP2C19 2141	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=47 Page: 47.0	no
CYP2C9 2497	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=47 Page: 47.0	no
CYP2D6 2546	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=47 Page: 47.0	no
CYP2E1 1146	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=47 Page: 47.0	no
CYP3A4 2633	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=47 Page: 47.0	no
P-gp 1932	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=27 Page: 27.0	no

Drug as victim

Target	Modality	Activity
CYP1A2 1197	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=41 Page: 41.0	no
CYP3A4 1946	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=41 Page: 41.0	no
P-gp 2052	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022273s000_ClinPharmR.pdf#page=27 Page: 27.0	weak

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B2-0955	http://www.3bsc.com/index/pro_info.php?id=41860
AA Blocks	AA0039N2	https://www.aablocks.com/goods/Goods/detail?id=AA0039N2
Aaron Chemicals	AR003AEU	http://www.aaronchem.com/21679-14-1
abcr GmbH	AB348142	http://www.abcr.com/shop/en/AB348142
AbMole Bioscience	M2028	http://www.abmole.com/products/fludarabine.html
Achemo Scientific Limited	AC-15243	http://www.achemo.com/search/?Keyword= 21679-14-1
Achemtek	0104-023119	http://www.achemtek.com/21679-14-1
Active Biopharma	ABP000557	http://www.activebiopharma.com/21679-14-1
AEchem Scientific Corp., USA	AE1-015944	http://www.aechemsc.com/info_products/AE1-015944.php
AHH Chemical co.,ltd	MT-51811	http://www.ahhchemical.com/product/MT-51811.html
Allbio Pharm Co., Ltd	AD08014	http://www.allbiopharm.com/product/n/AD08014
AstaTech, Inc.	HG1007	http://www.astatechinc.com/CPSResult.php?CRNO=17780
Aurora Fine Chemicals LLC	A24.077.320	http://online.aurorafinechemicals.com/info?ID=A24.077.320
Aurora Fine Chemicals LLC	K16.603.080	http://online.aurorafinechemicals.com/info?ID=K16.603.080
Aurum Pharmatech LLC	S-6059	http://www.Aurumpharmatech.com/Product/ProductDetails/S_6059
AvaChem Scientific	2653	http://www.avachem.com/productSearch.asp?2653
Avantor Inc	100576-076	https://us.vwr.com/store/catalog/product.jsp?catalog_number=100576-076
BioChemPartner	BCP01383	http://www.biochempartner.com/21679-14-1-BCP01383
BioCrick	BCC2518	http://www.biocrick.com/Fludarabine-BCC2518.html
BLD Pharm	BD11972	http://www.bldpharm.com/products/21679-14-1.html
BroadPharm	BP-25389	https://www.broadpharm.com/web/product.php?catalog=BP-25389
Chem Scene	CS-2133	http://www.chemscene.com/21679-14-1.html
ChemMol	97900454	http://www.chemmol.com/chemmol/97900454.html
Chemspace	CSSB00000743926	https://chem-space.com/CSSB00000743926
Combi-Blocks	QA-3101	http://www.combi-blocks.com/cgi-bin/find.cgi?QA-3101
CSNpharm	CSN10528	https://www.csnpharm.com/products/fludarabine.html
DC Chemicals	DC5889	http://www.dcchemicals.com/product_show-Fludarabine.html
Enamine	Z802671516	https://www.enaminestore.com/catalog/Z802671516
eNovation Chemicals	D481187	http://www.enovationchem.com/productDetails.asp?productID=D481187
eNovation Chemicals	D961702	https://www.enovationchem.com/ProductDetails.asp?ProductID=D961702
eNovation Chemicals	Y0974205	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y0974205
Excenen	EX-A833	http://www.excenen.com/searchresultlist.php?id=21679-14-1
Glentham Life Sciences	GP0730	http://www.glentham.com/products/product/GP0730/
Hairui	HR129788	http://www.hairuichem.com/en/product/21679-14-1.html
iChemical	EBD18913	http://www.ichemical.com/products/21679-14-1.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network	LN00175758	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00175758
Matrix Scientific	76060	https://www.matrixscientific.com/076060.html
mcule	MCULE-2497721739	https://mcule.com/MCULE-2497721739/
MedChem Express	HY-B0069	https://www.medchemexpress.com/fludarabine.html
MuseChem	A001054	https://www.musechem.com/product/A001054.html
Oakwood	79410	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=64584&ExtHyperLink=1
OChem	2832	http://www.ocheminc.com/index.php?act=psearch&pid=679F141
Parchem	28968	http://www.parchem.com/chemical-supplier-distributor/Fludarabine-018968.aspx
Selleck Chemicals	S1491	http://www.selleckchem.com/products/Fludarabine(Fludara).html
Sigma-Aldrich	F2773_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/f2773?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S528115	http://www.smolecule.com/products/s528115
Synblock Inc	SB19413	http://www.synblock.com/product/21679-14-1.html
Synchem UG and Co KG	67378	http://www.synchem.de/chemical_Fludarabine.html
THE BioTek	bt-268280	https://www.thebiotek.com/product/inhibitors/bt-268280
Tocris	3495	https://www.tocris.com/products/fludarabine_3495
VladaChem	VL281192-10MG	https://www.vladachem.com/product.php?products=21679-14-1

PubMed

Title	Date	PubMed
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.	2015-05-18	25811541
Inhibitory effect of leptin on rosiglitazone-induced differentiation of primary adipocytes prepared from TallyHO/Jng mice.	2011-03-25	21352814
The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling.	2011-01-15	20933509
Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells.	2010-07-25	20447390
Use of clofarabine for acute childhood leukemia.	2010-06-24	20631817
Incidence and susceptibility to therapy-related myeloid neoplasms.	2010-03-19	20026017
ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.	2009-02-20	19232100
Fludarabine in the treatment of chronic lymphocytic leukemia: a review.	2009-02	19436622
Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells.	2009-01	19006566
Oral fludarabine and cyclophosphamide as front-line chemotherapy in patients with chronic lymphocytic leukemia. The impact of biological parameters in the response duration.	2008-11	18587576
Fatal acute liver failure due to reactivation of hepatitis B following treatment with fludarabine/cyclophosphamide/rituximab for low grade non-Hodgkin's lymphoma.	2008-10-27	19008178
Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions.	2008-10	18852132
Treosulfan/fludarabine as an allogeneic hematopoietic stem cell transplant conditioning regimen for high-risk patients.	2008-09	18626885
Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells.	2008-05-15	18092340
Prodrug converting enzyme gene delivery by L. monocytogenes.	2008-04-10	18402662
Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia.	2008-03-15	18347188
Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells.	2008-03	18079738
Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: high response rate and disease eradication.	2008-01-01	18172266
Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial.	2007-07-21	17658394
Drug resistance in B-cell chronic lymphocytic leukemia: predictable by in vitro evaluation with a multiparameter flow cytometric cytotoxicity assay.	2007-05	17226861
Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia.	2007-03-20	17296974
Fatal leukoencephalopathy after reduced-intensity allogeneic stem cell transplantation.	2007-02	17264526
Myelopathy due to intrathecal chemotherapy: magnetic resonance imaging findings.	2007-02	17207701
Cutaneous recall phenomenon at the site of previous doxorubicin extravasation after second-line chemotherapy.	2007-01-17	17228004
STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines.	2007-01-01	17072862
[Prognostic significance of immunoglobulin variable region gene mutations in B-CLL patients treated with combination therapy fludarabine plus cyclophosphamide].	2007	17802794
Characterization of the rat Na+/nucleoside cotransporter 2 and transport of nucleoside-derived drugs using electrophysiological methods.	2006-12	16837649
Role of fludarabine in hematological malignancies.	2006-09	17020450
MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.	2006-05-15	16439685
Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).	2006-05-15	16439677
Chronic lymphocytic leukaemia, synchronous small cell carcinoma and squamous neoplasia of the urinary bladder in a paraplegic man following long-term phenoxybenzamine therapy.	2006-03	16130025
Phase I and pharmacokinetic study of oral fludarabine phosphate in relapsed indolent B-cell non-Hodgkin's lymphoma.	2006-02	16275653
Alteration of DNA methylation status in K562 and MCF-7 cancer cell lines by nucleoside analogues.	2006	17065059
Recurrent chemotherapy-induced tumor lysis syndrome (TLS) with renal failure in a patient with chronic lymphocytic leukemia - successful treatment and prevention of TLS with low-dose rasburicase.	2005-12	16313266
A highly sensitive high-performance liquid chromatography-mass spectrometry method for quantification of fludarabine triphosphate in leukemic cells.	2005-06-25	15899377
Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway.	2005-06-03	15850772
Resistance to 9-beta-D-arabinofuranosyl-2-fluoroadenine due to reduced incorporation into DNA from competition by excess deoxyadenosine triphosphate: implications for different sensitivities to nucleoside analogues.	2005-06	16158821
Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes.	2005-04-22	15701636
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway.	2004-12-16	15516989
Inhibition of repair of carboplatin-induced DNA damage by 9-beta-D-arabinofuranosyl-2-fluoroadenine in quiescent human lymphocytes.	2004-11-01	15450941
A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia.	2004-10-15	15501959
Fatal peripheral neuropathy following FLA chemotherapy.	2004-08	15279668
9-beta-D-arabinofuranosyl-2-fluoroadenine inhibits expression of vascular endothelial growth factor through hypoxia-inducible factor-1 in human ovarian cancer cells.	2004-07	15213310
Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene.	2004-05-24	15157282
Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells.	1998-08-15	9703875
Apoptosis induction with three nucleoside analogs on freshly isolated B-chronic lymphocytic leukemia cells.	1994-12	7977303
Fludarabine + Ara-C + G-CSF: cytotoxic effect and induction of apoptosis on fresh acute myeloid leukemia cells.	1994-12	7528855
Neurotoxicity associated with fludarabine and cytosine arabinoside chemotherapy for acute leukemia and myelodysplasia.	1993-03	8445943
Fludarabine and arabinosylcytosine therapy of refractory and relapsed acute myelogenous leukemia.	1993-03	8394169
In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells.	1982-03	7048062

Patents

Sample Use Guides

In Vivo Use Guide

Chronic Lymphocytic Leukemia (CLL): The recommended adult dose is 25 mg/m2 administered intravenously over a period of approximately 30 minutes daily for five consecutive days. Each 5-day course of treatment should commence every 28 days.

Route of Administration: Intravenous

In Vitro Use Guide

The growth of RPMI8226 and KM3 cells was suppressed by fludarabine treatment in a dose and time-dependent manner. After treatment with fludarabine for 24 h, the IC(50) for RPMI8226 cells was 2.13 µg/ml, and 0.36 µg/ml for KM3 cells. Apoptotic cells of RPMI8226 and KM3 increased in a dose- dependent manner after exposure to fludarabine for 24 h. Western blot analysis showed the activation of caspase-3 and PARP in the MM cells treated with fludarabine.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:57:49 GMT 2025` Edited by `admin` on `Mon Mar 31 17:57:49 GMT 2025`
Record UNII	1X9VK9O1SC
Record Status	`Validated (UNII)`
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Name

Type

Language

FLUDARABINE 5'-MONOPHOSPHATE

Preferred Name

English

FLUDARABINE PHOSPHATE

Official Name

English

NSC-328002

Code

English

FLUDARA

Brand Name

English

FLUDARABINE 5'-MONOPHOSPHATE [MI]

Common Name

English

FLUDARABINE PHOSPHATE [JAN]

Common Name

English

FLUDARABINE PHOSPHATE [EP MONOGRAPH]

Common Name

English

FLUDARABINE PHOSPHATE [USAN]

Common Name

English

9-.BETA.-D-ARABINOFURANOSYL-2-FLUOROADENINE 5'-(DIHYDROGEN PHOSPHATE)

Common Name

English

FLUDARABINE PHOSPHATE [VANDF]

Common Name

English

2-F-ARA-AMP

Common Name

English

FLUDARABINE PHOSPHATE [MART.]

Common Name

English

FLUDARABINE PHOSPHATE [USP-RS]

Common Name

English

FLUDARABINE PHOSPHATE [ORANGE BOOK]

Common Name

English

NSC-312887

Code

English

9H-PURIN-6-AMINE, 2-FLUORO-9-(5-O-PHOSPHONO-.BETA.-D-ARABINOFURANOSYL)-

Common Name

English

FLUDARABINE MONOPHOSPHATE

Common Name

English

FLUDARABINE PHOSPHATE [USP MONOGRAPH]

Common Name

English

Fludarabine phosphate [WHO-DD]

Common Name

English

OFORTA

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1556