Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H4FN5 |
| Molecular Weight | 153.1172 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(F)=NC2=C1NC=N2
InChI
InChIKey=WKMPTBDYDNUJLF-UHFFFAOYSA-N
InChI=1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT. | 2009-12-03 |
|
| Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. | 2009-10-02 |
|
| Diastereocontrolled electrophilic fluorinations of 2-deoxyribonolactone: syntheses of all corresponding 2-deoxy-2-fluorolactones and 2'-deoxy-2'-fluoro-NAD+s. | 2009-08-21 |
|
| A limited sampling schedule to estimate individual pharmacokinetic parameters of fludarabine in hematopoietic cell transplant patients. | 2009-08-15 |
|
| Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. | 2009-05-29 |
|
| Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine. | 2009-05 |
|
| Key labeling technologies to tackle sizeable problems in RNA structural biology. | 2008-06 |
|
| Prodrug converting enzyme gene delivery by L. monocytogenes. | 2008-04-10 |
|
| Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain. | 2008-02 |
|
| Comparison of gene targeting efficiencies in two mosses suggests that it is a conserved feature of Bryophyte transformation. | 2007-10 |
|
| [(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions. | 2007-09 |
|
| Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase. | 2007-04-03 |
|
| Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine. | 2006 |
|
| Cytosine arabinoside affects multiple cellular factors and induces drug resistance in human lymphoid cells. | 2005-08-01 |
|
| Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex. | 2005-06-10 |
|
| Oligotide, a defibrotide derivative, protects human microvascular endothelial cells against fludarabine-induced activation, damage and allogenicity. | 2005-05 |
|
| Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. | 2005-03 |
|
| Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer. | 2005 |
|
| Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus. | 2004-11 |
|
| Enzymatic synthesis and 19F NMR studies of 2-fluoroadenine-substituted RNA. | 2004-09-29 |
|
| Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. | 2004-02-26 |
|
| Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease. | 2004-01 |
|
| Synthesis of 2-fluoronoraristeromycin and its inhibitory activity against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. | 2003-11-17 |
|
| Convenient synthesis of 2'-deoxy-2-fluoroadenosine from 2-fluoroadenine. | 2003-10 |
|
| Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. | 2003 |
|
| Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide. | 2002-07-01 |
|
| Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models. | 2002-06 |
|
| Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells. | 2001-02 |
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C45176
Created by
admin on Mon Mar 31 21:27:55 GMT 2025 , Edited by admin on Mon Mar 31 21:27:55 GMT 2025
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NCI_THESAURUS |
C45183
Created by
admin on Mon Mar 31 21:27:55 GMT 2025 , Edited by admin on Mon Mar 31 21:27:55 GMT 2025
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72457
Created by
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C29794
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2C8H3H4EBG
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700-49-2
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DTXSID80220264
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27364
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12790
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SUBSTANCE RECORD
