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Search results for temozolomide in Standardized Name (approximate match)
Showing 1 - 9 of 9 results
Status:
US Approved Rx
(2014)
Source:
ANDA201742
(2014)
Source URL:
First approved in 1999
Source:
TEMODAR by MERCK SHARP DOHME
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
NEO 212 is novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. NEO212 is a conjugate of temozolomide (TMZ,) with the natural product perillyl alcohol (POH). NEO 212 causes DNA damage and cell death much more efficiently than TMZ because linkage with POH increased it's biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions.
Status:
Investigational
Source:
Tokai J Exp Clin Med. May 1990;15(2-3):123-7.: Not Applicable Human clinical trial Completed Liver Cirrhosis, Alcoholic/physiopathology
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Temozolomide acid is the inactive metabolite of temozolomide. However, it was demonstrated to have small anti-cancer activity in vitro.
Status:
US Approved Rx
(2014)
Source:
ANDA201742
(2014)
Source URL:
First approved in 1999
Source:
TEMODAR by MERCK SHARP DOHME
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
NEO 212 is novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. NEO212 is a conjugate of temozolomide (TMZ,) with the natural product perillyl alcohol (POH). NEO 212 causes DNA damage and cell death much more efficiently than TMZ because linkage with POH increased it's biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions.
