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Details

Stereochemistry ACHIRAL
Molecular Formula C6H6N6O2
Molecular Weight 194.1508
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TEMOZOLOMIDE

SMILES

CN1N=NC2=C(N=CN2C1=O)C(N)=O

InChI

InChIKey=BPEGJWRSRHCHSN-UHFFFAOYSA-N
InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

HIDE SMILES / InChI

Description

NEO 212 is novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. NEO212 is a conjugate of temozolomide (TMZ,) with the natural product perillyl alcohol (POH). NEO 212 causes DNA damage and cell death much more efficiently than TMZ because linkage with POH increased it's biological half-life and thus provided greater opportunity for placement of cytotoxic DNA lesions.

CNS Activity

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

Sample Use Guides

In Vivo Use Guide
intravenous infusion over 90 minutes is the same as the dose for the oral capsule formulation. Bioequivalence has been established only when TEMODAR for Injection was given over 90 minutes.
Route of Administration: subcutaneously
In Vitro Use Guide
Grade IV glioma cell lines SHG44 and U251 cells were treated with 100 µmol/LT EMOZOLOMIDE (TMZ)
Name Type Language
TEMOZOLOMIDE
EMA EPAR   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
TEMOZOLOMIDE [INN]
Common Name English
MK-7365
Common Name English
NSC-362856
Code English
TEMOZOLOMIDE [EMA EPAR]
Common Name English
CCRG-81045
Code English
M&B-39831
Code English
M-39831
Code English
METHAZOLASTONE
Common Name English
SCH 52365
Code English
TEMOZOLOMIDE [JAN]
Common Name English
TEMOZOLOMIDE [USAN]
Common Name English
TEMOZOLOMIDE [ORANGE BOOK]
Common Name English
TEMOZOLOMIDE [WHO-DD]
Common Name English
SCH-52365
Code English
3,4-DIHYDRO-3-METHYL-4-OXOIMIDAZO(5,1-D)-AS-TETRAZINE-8-CARBOXAMIDE
Common Name English
IMIDAZO(5,1-D)-1,2,3,5-TETRAZINE-8-CARBOXAMIDE, 3,4-DIHYDRO-3-METHYL-4-OXO-
Systematic Name English
TEMOZOLOMIDE [USP-RS]
Common Name English
TEMOZOLOMIDE [MART.]
Common Name English
TEMODAL
Brand Name English
TEMOZOLOMIDE [MI]
Common Name English
M&B 39831
Code English
TEMODAR
Brand Name English
TEMOZOLOMIDE [VANDF]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C902
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
NDF-RT N0000175558
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
WHO-ATC L01AX03
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
NDF-RT N0000000236
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
FDA ORPHAN DRUG 116798
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
EMA ASSESSMENT REPORTS TEMOZOLOMIDE SUN (AUTHORIZED: GLIOMA, GLIOBLASTOMA)
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
EMA ASSESSMENT REPORTS TEMOZOLOMIDE TEVA (AUTHORIZED: GLIOMA, GLIOBLASTOMA)
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
EMA ASSESSMENT REPORTS TEMOZOLOMIDE SANDOZ (AUTHORIZED: GLIOMA, GLIOBLASTOMA)
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
EMA ASSESSMENT REPORTS TEMOZOLOMIDE HEXAL (AUTHORIZED: GLIOMA, GLIOBLASTOMA)
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
FDA ORPHAN DRUG 193904
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
WHO-VATC QL01AX03
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
EMA ASSESSMENT REPORTS TEMOMEDAC (AUTHORIZED: GLIOMA, GLIOBLASTOMA)
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
FDA ORPHAN DRUG 453314
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
EU-Orphan Drug EU/3/16/1733
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
FDA ORPHAN DRUG 497215
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
EMA ASSESSMENT REPORTS TEMODAL (AUTHORIZED: GLIOMA, GLIOBLASTOMA)
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
LIVERTOX 932
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
EMA ASSESSMENT REPORTS TEMOZOLOMIDE ACCORD (AUTHORIZED: GLIOMA, GLIOBLASTOMA
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
FDA ORPHAN DRUG 117198
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
Code System Code Type Description
EPA CompTox
85622-93-1
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
MESH
C047246
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
RXCUI
37776
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY RxNorm
CAS
85622-93-1
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
EVMPD
SUB10889MIG
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
ChEMBL
CHEMBL810
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
INN
6027
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
MERCK INDEX
M10552
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY Merck Index
WIKIPEDIA
TEMOZOLOMIDE
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
PUBCHEM
5394
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
DRUG BANK
DB00853
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
IUPHAR
7301
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY
NCI_THESAURUS
C1244
Created by admin on Mon Oct 21 20:20:31 UTC 2019 , Edited by admin on Mon Oct 21 20:20:31 UTC 2019
PRIMARY