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Restrict the search for
desflurane
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There is one exact (name or code) match for desflurane
Status:
US Approved Rx
(1992)
Source:
NDA020118
(1992)
Source URL:
First approved in 1992
Source:
NDA020118
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Desflurane is a non-flammable liquid administered via vaporizer as a general anesthetic. It is halogenated exclusively with fluorine and is very resistant to defluorination. For this reason, it is not associated with nephrotoxicity, as is the case with other inhalational anesthetics. Desflurane is indicated for the induction and/or maintenance of anesthesia and adults, and for maintenance of anesthesia in pediatric patients following the induction with other agents.
Status:
US Approved Rx
(1992)
Source:
NDA020118
(1992)
Source URL:
First approved in 1992
Source:
NDA020118
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Desflurane is a non-flammable liquid administered via vaporizer as a general anesthetic. It is halogenated exclusively with fluorine and is very resistant to defluorination. For this reason, it is not associated with nephrotoxicity, as is the case with other inhalational anesthetics. Desflurane is indicated for the induction and/or maintenance of anesthesia and adults, and for maintenance of anesthesia in pediatric patients following the induction with other agents.
Status:
US Approved Rx
(1999)
Source:
ANDA075225
(1999)
Source URL:
First approved in 1979
Source:
NDA017624
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Isoflurane (1-chloro-2, 2,2-trifluoroethyl difluoromethyl ether) a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Similar to many general anesthetics, the exact mechanism of the action has not been clearly delineated. Isoflurane reduces pain sensitivity (analgesia) and relaxes muscles. Isoflurane likely potentiates GABA-A and glycine receptor activity, which decreases motor function, inhibits receptor activity in the NMDA glutamate receptor subtypes and binds to glutamate receptors. Isoflurane is always administered in conjunction with air and/or pure oxygen. Often nitrous oxide is also used. Although its physical properties imply that anesthesia can be induced more rapidly than with halothane, its pungency can irritate the respiratory system, negating this theoretical advantage conferred by its physical properties. It is usually used to maintain a state of general anesthesia that has been induced with another drug, such as thiopentone or propofol.
Status:
US Previously Marketed
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Acetone (or propanone) is the smallest and simplest ketone, which is used in cosmetic as a nail polish remover. Acetone is produced within the body because of the breakdown of stored fats and lipids as a source of energy. Such conditions as physical exercise and prolonged dieting, which lead to cleavage of fat within the body, may result in higher than average amounts of acetone in the bloodstream. The concentration of acetone in the environment doesn’t cause a neurotoxic, carcinogenic, or reproductive health hazard effect. In addition, experiments on rodents have shown that acetone possesses anticonvulsant properties.
Status:
US Previously Marketed
First marketed in 1847
Class (Stereo):
CHEMICAL (ACHIRAL)
Chloroform is a colorless, sweet-smelling, dense liquid and widely used industrial and laboratory solvent. The total global flux of chloroform through the environment is approximately 660 000 tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Chloroform is used as an industrial solvent and as an intermediate in the manufacture of polymeric materials. The major use of chloroformtoday is in the production of the refrigerant R-22, commonly used in the air conditioning business. Inhaled chloroform anesthesia was introduced in 1847 and Chloroform subsequently became the most widely used volatile anaesthetic, and was used in horses before the end of the 19th century. Pure chloroform is known to be decomposed by the air with the formation of hydrochloric acid, phosgene and carbon dioxide. Phosgene is also generated metabolically from chloroform, and liver and kidney damage can ensue from its production.
Status:
Possibly Marketed Outside US
Source:
ANDA072273
(1996)
Source URL:
First approved in 1996
Source:
ANDA072273
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Dichlorofluoromethane is a colorless heavy gas that is used as a refrigerant, solvent, propellant and heat-exchange fluid. It is also referred to as CFC-21 but has fewer uses than other chlorofluorocarbons. Inhalation of dichlorofluoromethane can cause confusion, drowsiness, and unconsciousness; and direct contact with skin can cause frostbite.
Status:
Possibly Marketed Outside US
Source:
ANDA072273
(1996)
Source URL:
First approved in 1996
Source:
ANDA072273
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Trichlorofluoromethane, also known as freon-11, was used as propellant and refrigerant. Its production was banned because of the destroying of the ozone layer and contribution to the formation of the so-called ozone hole. Today, trichlorofluoromethane is obtained during recycling processes of waste cooling devices, traded on the black market, and according to recent findings still illegally manufactured.
