U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CHCl3
Molecular Weight 119.378
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLOROFORM

SMILES

ClC(Cl)Cl

InChI

InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N
InChI=1S/CHCl3/c2-1(3)4/h1H

HIDE SMILES / InChI

Molecular Formula CHCl3
Molecular Weight 119.378
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Chloroform is a colorless, sweet-smelling, dense liquid and widely used industrial and laboratory solvent. The total global flux of chloroform through the environment is approximately 660 000 tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Chloroform is used as an industrial solvent and as an intermediate in the manufacture of polymeric materials. The major use of chloroformtoday is in the production of the refrigerant R-22, commonly used in the air conditioning business. Inhaled chloroform anesthesia was introduced in 1847 and Chloroform subsequently became the most widely used volatile anaesthetic, and was used in horses before the end of the 19th century. Pure chloroform is known to be decomposed by the air with the formation of hydrochloric acid, phosgene and carbon dioxide. Phosgene is also generated metabolically from chloroform, and liver and kidney damage can ensue from its production.

Approval Year

AUC

AUC

ValueDoseCo-administeredAnalytePopulation
176 μg × min/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: FEMALE
food status: UNKNOWN
293 μg × min/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
86 min
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: FEMALE
food status: UNKNOWN
96 min
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Disc. AE: Loss of consciousness, Hypotension...
AEs leading to
discontinuation/dose reduction:
Loss of consciousness
Hypotension
Respiratory depression (severe)
Abdominal pain (severe)
Vomiting
Diarrhea
Enterocolitis (severe)
Erosive oesophagitis (severe)
Gastritis erosive (severe)
Ulceration (severe)
Contact dermatitis
ALT increased
AST increased
Sources: Page: p.1,2
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Disc. AE: Respiratory failure, Cardiac arrhythmias...
AEs leading to
discontinuation/dose reduction:
Respiratory failure (grade 5)
Cardiac arrhythmias (grade 5)
Cardiac failure (grade 5)
Sources: Page: p.26
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Disc. AE: Dizziness, Intracranial pressure increase...
AEs leading to
discontinuation/dose reduction:
Dizziness
Intracranial pressure increase
Nausea
Headache
Sources:
AEs

AEs

AESignificanceDosePopulation
ALT increased Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
AST increased Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Contact dermatitis Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Diarrhea Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Hypotension Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Loss of consciousness Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Vomiting Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Abdominal pain severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Enterocolitis severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Erosive oesophagitis severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Gastritis erosive severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Respiratory depression severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Ulceration severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Cardiac arrhythmias grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Cardiac failure grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Respiratory failure grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Dizziness Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Headache Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Intracranial pressure increase Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Nausea Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as victimTox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Identification of an extracellular agent [correction of catalyst] of carbon tetrachloride dehalogenation from Pseudomonas stutzeri strain KC as pyridine-2, 6-bis(thiocarboxylate).
1999 Aug 11
Effect of trihalomethanes on cell proliferation and DNA methylation in female B6C3F1 mouse liver.
2000 Dec
Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone.
2001
Catalytic effect of soil colloids on the reaction between CrVI and p-methoxyphenol.
2001
Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E.
2001 Apr
The Bacillus subtilis yabQ gene is essential for formation of the spore cortex.
2001 Apr
Anesthetic-like interactions of nitric oxide with albumin and hemeproteins. A mechanism for control of protein function.
2001 Apr 27
Oxidative degradation study of nitrendipine using stability indicating, HPLC, HPTLC and spectrophotometric method.
2001 Feb
A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors.
2001 Feb
DNA isolation from chloroform/methanol-treated mycobacterial cells without lysozyme and proteinase K.
2001 Feb
Antibacterial activity of Punica granatum.
2001 Feb
Antibacterial activity of Barringtonia racemosa.
2001 Feb
Rapid reductive destruction of hazardous organic compounds by nanoscale Fe0.
2001 Feb
Photocatalytic degradation of gaseous perchloroethylene: products and pathway.
2001 Feb
Carbon tetrachloride dechlorination by the bacterial transition metal chelator pyridine-2,6-bis(thiocarboxylic acid).
2001 Feb 1
Fluorometric method for the simultaneous quantitation of differently-sized nanoparticles in rodent tissue.
2001 Feb 19
Understanding the role of internal lysine residues of serum albumins in conformational stability and bilirubin binding.
2001 Feb 9
Hazardous air pollutants formation from reactions of raw meal organics in cement kilns.
2001 Feb-Mar
Formation and decomposition of chloroaromatic compounds in chlorine-containing benzene/oxygen flames.
2001 Feb-Mar
Determination of cilostazol and its metabolites in human urine by high performance liquid chromatography.
2001 Jan
A 1:1:1 chloroform/tetrahydrofuran solvate of p-tert-butyltetrahomodioxacalix[4]arene.
2001 Jan
Augmented expression of peroxiredoxin VI in rat lung and kidney after birth implies an antioxidative role.
2001 Jan
Antibacterial effect of the culture fluid of Lentinus edodes mycelium grown in submerged liquid culture.
2001 Jan
Preparations, characterizations, and structures of (biimidazole)dihalobis(triphenylphosphine)rhenium(III) salts: strong ion-pairing and acid-base properties.
2001 Jan 1
Monthly variations in diarrhetic toxins and yessotoxin in shellfish from coast to the inner part of the Sognefjord, Norway.
2001 Jul
Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.
2001 Mar 15
Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water.
2001 May
An improved method for isolation of unconjugated bilirubin from rat and dog bile.
2001 May
Evaluation of extraction methods from paraffin wax embedded tissues for PCR amplification of human and viral DNA.
2001 May
Screening of various Swertia species extracts in primary monolayer cultures of rat hepatocytes against carbon tetrachloride- and paracetamol-induced toxicity.
2001 May
Rigorous interpretation of electronic density functions of axial and equatorial conformers of dimethylphosphinoylcyclohexane, 2-(dimethylphosphinoyl)-1,3,5-trithiane, and 2-(dimethylphosphinoyl)-1,3-dithiane-1,1,3,3-tetraoxide.
2001 May 4
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:09:44 GMT 2023
Edited
by admin
on Fri Dec 15 15:09:44 GMT 2023
Record UNII
7V31YC746X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLOROFORM
GREEN BOOK   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
CHLOROFORM [GREEN BOOK]
Common Name English
CHLOROBUTANOL IMPURITY A [EP IMPURITY]
Common Name English
CHLOROFORM [USP-RS]
Common Name English
CHLOROFORM [MART.]
Common Name English
CHLOROFORM [II]
Common Name English
Chloroform [WHO-DD]
Common Name English
CHLOROFORM [MI]
Common Name English
NSC-77361
Code English
CHLOROFORM [VANDF]
Common Name English
HCC 20
Common Name English
CHLOROFORM [HSDB]
Common Name English
CHLOROFORM BP
Common Name English
CHLOROFORM [INCI]
Common Name English
R 20 (REFRIGERANT)
Common Name English
METHANE, TRICHLORO-
Systematic Name English
Trichloromethane
Systematic Name English
CHLOROFORMUM [HPUS]
Common Name English
CHLOROFORM [IARC]
Common Name English
CHLOROFORMUM
HPUS  
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 20701
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
WHO-VATC QN01AB02
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
NCI_THESAURUS C45386
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
IARC Chloroform
WHO-ATC N01AB02
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
CFR 21 CFR 310.502
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
CFR 21 CFR 700.18
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
Code System Code Type Description
CHEBI
35255
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
CAS
67-66-3
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-663-8
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
DRUG CENTRAL
4363
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
RS_ITEM_NUM
1601383
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
HSDB
56
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
CONCEPT Industrial Aid
MERCK INDEX
m3412
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL44618
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
EPA CompTox
DTXSID1020306
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
EVMPD
SUB13331MIG
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
NSC
77361
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
EVMPD
SUB13333MIG
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
ALTERNATIVE
NCI_THESAURUS
C29815
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
MESH
D002725
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
RXCUI
1362698
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY RxNorm
PUBCHEM
6212
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
FDA UNII
7V31YC746X
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
SMS_ID
100000080074
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
ALANWOOD
chloroform
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
DAILYMED
7V31YC746X
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
WIKIPEDIA
CHLOROFORM
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
DRUG BANK
DB11387
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
EVMPD
SUB29129
Created by admin on Fri Dec 15 15:09:44 GMT 2023 , Edited by admin on Fri Dec 15 15:09:44 GMT 2023
PRIMARY
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