U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CHCl3
Molecular Weight 119.378
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLOROFORM

SMILES

ClC(Cl)Cl

InChI

InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N
InChI=1S/CHCl3/c2-1(3)4/h1H

HIDE SMILES / InChI

Molecular Formula CHCl3
Molecular Weight 119.378
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Chloroform is a colorless, sweet-smelling, dense liquid and widely used industrial and laboratory solvent. The total global flux of chloroform through the environment is approximately 660 000 tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Chloroform is used as an industrial solvent and as an intermediate in the manufacture of polymeric materials. The major use of chloroformtoday is in the production of the refrigerant R-22, commonly used in the air conditioning business. Inhaled chloroform anesthesia was introduced in 1847 and Chloroform subsequently became the most widely used volatile anaesthetic, and was used in horses before the end of the 19th century. Pure chloroform is known to be decomposed by the air with the formation of hydrochloric acid, phosgene and carbon dioxide. Phosgene is also generated metabolically from chloroform, and liver and kidney damage can ensue from its production.

Approval Year

AUC

AUC

ValueDoseCo-administeredAnalytePopulation
176 μg × min/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: FEMALE
food status: UNKNOWN
293 μg × min/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
86 min
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: FEMALE
food status: UNKNOWN
96 min
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Disc. AE: Loss of consciousness, Hypotension...
AEs leading to
discontinuation/dose reduction:
Loss of consciousness
Hypotension
Respiratory depression (severe)
Abdominal pain (severe)
Vomiting
Diarrhea
Enterocolitis (severe)
Erosive oesophagitis (severe)
Gastritis erosive (severe)
Ulceration (severe)
Contact dermatitis
ALT increased
AST increased
Sources: Page: p.1,2
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Disc. AE: Respiratory failure, Cardiac arrhythmias...
AEs leading to
discontinuation/dose reduction:
Respiratory failure (grade 5)
Cardiac arrhythmias (grade 5)
Cardiac failure (grade 5)
Sources: Page: p.26
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Disc. AE: Dizziness, Intracranial pressure increase...
AEs leading to
discontinuation/dose reduction:
Dizziness
Intracranial pressure increase
Nausea
Headache
Sources:
AEs

AEs

AESignificanceDosePopulation
ALT increased Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
AST increased Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Contact dermatitis Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Diarrhea Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Hypotension Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Loss of consciousness Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Vomiting Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Abdominal pain severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Enterocolitis severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Erosive oesophagitis severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Gastritis erosive severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Respiratory depression severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Ulceration severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Cardiac arrhythmias grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Cardiac failure grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Respiratory failure grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Dizziness Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Headache Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Intracranial pressure increase Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Nausea Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as victimTox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone.
2001
Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus.
2001
[New studies on the history of anesthesiology--(7). What anesthetics were given to soldiers of the fifth regiment rescued from death march on Mount Hakkoda?].
2001 Apr
The Bacillus subtilis yabQ gene is essential for formation of the spore cortex.
2001 Apr
Inhibiting effects of chloroform on anaerobic microbial consortia as monitored by the Rantox biosensor.
2001 Apr
Anesthetic-like interactions of nitric oxide with albumin and hemeproteins. A mechanism for control of protein function.
2001 Apr 27
Influence of N-terminal residue stereochemistry on the prolyl amide geometry and the conformation of 5-tert-butylproline type VI beta-turn mimics.
2001 Feb
Stabilisation of [131I]meta-iodobenzylguanidine at room temperature as organic extract in ethyl acetate/chloroform.
2001 Feb
Rapid reductive destruction of hazardous organic compounds by nanoscale Fe0.
2001 Feb
Carbon tetrachloride dechlorination by the bacterial transition metal chelator pyridine-2,6-bis(thiocarboxylic acid).
2001 Feb 1
Reductive dechlorination of cis-1,2-dichloroethene and vinyl chloride by "Dehalococcoides ethenogenes".
2001 Feb 1
Fluorometric method for the simultaneous quantitation of differently-sized nanoparticles in rodent tissue.
2001 Feb 19
The (1)H NMR chemical shift for the hydroxy proton of 4-(dimethylamino)-2'-hydroxychalcone in chloroform: a theoretical approach to its inverse dependence on the temperature.
2001 Feb 22
Selective extraction of subunit D of the Na(+)-translocating methyltransferase and subunit c of the A(1)A(0) ATPase from the cytoplasmic membrane of methanogenic archaea by chloroform/methanol and characterization of subunit c of Methanothermobacter thermoautotrophicus as a 16-kDa proteolipid.
2001 Feb 5
Effect of depletion of FtsY on spore morphology and the protein composition of the spore coat layer in Bacillus subtilis.
2001 Feb 5
Phospholipase D-catalyzed transphosphatidylation in anhydrous organic solvents.
2001 Feb 5
Invertebrate anesthesia.
2001 Jan
Determination of cilostazol and its metabolites in human urine by high performance liquid chromatography.
2001 Jan
A 1:1:1 chloroform/tetrahydrofuran solvate of p-tert-butyltetrahomodioxacalix[4]arene.
2001 Jan
Augmented expression of peroxiredoxin VI in rat lung and kidney after birth implies an antioxidative role.
2001 Jan
Phytochemical and antimicrobial study of Chukrasia tabularis leaves.
2001 Jan
Drinking water contaminants and childhood leukemia.
2001 Jan
ESR-spin trapping study on the sonochemistry of liquids in the presence of oxygen. Evidence for the superoxide radical anion formation.
2001 Jan
Occupational exposure to trihalomethanes in indoor swimming pools.
2001 Jan 17
Long-acting delivery microspheres of levo-norgestrol-poly(3-hydroxybutyrate): their preparation, characterization and contraceptive tests on mice.
2001 Jan-Feb
Monthly variations in diarrhetic toxins and yessotoxin in shellfish from coast to the inner part of the Sognefjord, Norway.
2001 Jul
Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function.
2001 Jul 6
Efficiency of rice bran for removal of organochlorine compounds and benzene from industrial wastewater.
2001 Mar
Biosynthesis of PHB tercopolymer by Bacillus cereus UW85.
2001 Mar
Molecular mechanisms of anesthesia.
2001 Mar
Mast cell stabilising activity of Bacopa monnieri.
2001 Mar
Transient absorption from the 1Bu+ state of all-trans-beta-carotene newly identified in the near-infrared region.
2001 Mar
Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts.
2001 Mar 14
Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.
2001 Mar 15
Photochemistry of the pi-extended 9,10-bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene system: generation and characterisation of the radical cation, dication, and derived products.
2001 Mar 2
Chloroform-soluble schiff-base Zn(II) or Cd(II) complexes from a dynamic combinatorial library.
2001 Mar 26
Synthesis, aggregation, and binding behavior of synthetic amphiphilic receptors.
2001 Mar 9
Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity.
2001 May
A controlled field experiment on groundwater contamination by a multicomponent DNAPL: creation of the emplaced-source and overview of dissolved plume development.
2001 May
Evaluation of extraction methods from paraffin wax embedded tissues for PCR amplification of human and viral DNA.
2001 May
Bactericidal properties of the chloroform fraction from rhizomes of Aristolochia paucinervis Pomel.
2001 May
Sequence specificity of hydrogen-bonded molecular duplexes.
2001 May 18
Rigorous interpretation of electronic density functions of axial and equatorial conformers of dimethylphosphinoylcyclohexane, 2-(dimethylphosphinoyl)-1,3,5-trithiane, and 2-(dimethylphosphinoyl)-1,3-dithiane-1,1,3,3-tetraoxide.
2001 May 4
Lipase catalyzed synthesis of organic acid esters of lactic acid in non-aqueous media.
2001 May 4
Substance Class Chemical
Created
by admin
on Fri Dec 16 16:21:50 UTC 2022
Edited
by admin
on Fri Dec 16 16:21:50 UTC 2022
Record UNII
7V31YC746X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLOROFORM
GREEN BOOK   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
CHLOROFORM [GREEN BOOK]
Common Name English
CHLOROBUTANOL IMPURITY A [EP IMPURITY]
Common Name English
CHLOROFORM [USP-RS]
Common Name English
CHLOROFORM [MART.]
Common Name English
CHLOROFORM [II]
Common Name English
Chloroform [WHO-DD]
Common Name English
CHLOROFORM [MI]
Common Name English
NSC-77361
Code English
CHLOROFORM [VANDF]
Common Name English
HCC 20
Common Name English
CHLOROFORM [HSDB]
Common Name English
CHLOROFORM BP
Common Name English
CHLOROFORM [INCI]
Common Name English
R 20 (REFRIGERANT)
Common Name English
METHANE, TRICHLORO-
Systematic Name English
Trichloromethane
Systematic Name English
CHLOROFORMUM [HPUS]
Common Name English
CHLOROFORM [IARC]
Common Name English
CHLOROFORMUM
HPUS  
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 20701
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
WHO-VATC QN01AB02
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
NCI_THESAURUS C45386
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
IARC Chloroform
WHO-ATC N01AB02
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
CFR 21 CFR 310.502
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
CFR 21 CFR 700.18
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
Code System Code Type Description
CHEBI
35255
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
CAS
67-66-3
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
ECHA (EC/EINECS)
200-663-8
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
DRUG CENTRAL
4363
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
RS_ITEM_NUM
1601383
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
HSDB
56
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
CONCEPT Industrial Aid
MERCK INDEX
M3412
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY Merck Index
ChEMBL
CHEMBL44618
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
EPA CompTox
DTXSID1020306
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
EVMPD
SUB13331MIG
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
NSC
77361
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
EVMPD
SUB13333MIG
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
ALTERNATIVE
NCI_THESAURUS
C29815
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
MESH
D002725
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
RXCUI
1362698
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY RxNorm
PUBCHEM
6212
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
FDA UNII
7V31YC746X
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
ALANWOOD
chloroform
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
DAILYMED
7V31YC746X
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
WIKIPEDIA
CHLOROFORM
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
DRUG BANK
DB11387
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
EVMPD
SUB29129
Created by admin on Fri Dec 16 16:21:50 UTC 2022 , Edited by admin on Fri Dec 16 16:21:50 UTC 2022
PRIMARY
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