Details
Stereochemistry | ACHIRAL |
Molecular Formula | CHCl3 |
Molecular Weight | 119.378 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC(Cl)Cl
InChI
InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N
InChI=1S/CHCl3/c2-1(3)4/h1H
Molecular Formula | CHCl3 |
Molecular Weight | 119.378 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Chloroform is a colorless, sweet-smelling, dense liquid and widely used industrial and laboratory solvent. The total global flux of chloroform through the environment is approximately 660 000 tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Chloroform is used as an industrial solvent and as an intermediate in the manufacture of polymeric materials. The major use of chloroformtoday is in the production of the refrigerant R-22, commonly used in the air conditioning business. Inhaled chloroform anesthesia was introduced in 1847 and Chloroform subsequently became the most widely used volatile anaesthetic, and was used in horses before the end of the 19th century. Pure chloroform is known to be decomposed by the air with the formation of hydrochloric acid, phosgene and carbon dioxide. Phosgene is also generated metabolically from chloroform, and liver and kidney damage can ensue from its production.
Originator
Approval Year
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
293 μg × min/mL |
500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered: |
CHLOROFORM blood | Homo sapiens population: UNKNOWN age: UNKNOWN sex: MALE food status: UNKNOWN |
|
176 μg × min/mL |
500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered: |
CHLOROFORM blood | Homo sapiens population: UNKNOWN age: UNKNOWN sex: FEMALE food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
96 min |
500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered: |
CHLOROFORM blood | Homo sapiens population: UNKNOWN age: UNKNOWN sex: MALE food status: UNKNOWN |
|
86 min |
500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered: |
CHLOROFORM blood | Homo sapiens population: UNKNOWN age: UNKNOWN sex: FEMALE food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
30 mL single, oral Overdose |
healthy, 30 |
Disc. AE: Loss of consciousness, Hypotension... AEs leading to discontinuation/dose reduction: Loss of consciousness Sources: Hypotension Respiratory depression (severe) Abdominal pain (severe) Vomiting Diarrhea Enterocolitis (severe) Erosive oesophagitis (severe) Gastritis erosive (severe) Ulceration (severe) Contact dermatitis ALT increased AST increased |
73 g/m3 single, respiratory Recommended Dose: 73 g/m3 Route: respiratory Route: single Dose: 73 g/m3 Sources: |
unknown |
Disc. AE: Respiratory failure, Cardiac arrhythmias... AEs leading to discontinuation/dose reduction: Respiratory failure (grade 5) Sources: Cardiac arrhythmias (grade 5) Cardiac failure (grade 5) |
1030 ppm single, respiratory Studied dose Dose: 1030 ppm Route: respiratory Route: single Dose: 1030 ppm Sources: |
healthy |
Disc. AE: Dizziness, Intracranial pressure increase... AEs leading to discontinuation/dose reduction: Dizziness Sources: Intracranial pressure increase Nausea Headache |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
ALT increased | Disc. AE | 30 mL single, oral Overdose |
healthy, 30 |
AST increased | Disc. AE | 30 mL single, oral Overdose |
healthy, 30 |
Contact dermatitis | Disc. AE | 30 mL single, oral Overdose |
healthy, 30 |
Diarrhea | Disc. AE | 30 mL single, oral Overdose |
healthy, 30 |
Hypotension | Disc. AE | 30 mL single, oral Overdose |
healthy, 30 |
Loss of consciousness | Disc. AE | 30 mL single, oral Overdose |
healthy, 30 |
Vomiting | Disc. AE | 30 mL single, oral Overdose |
healthy, 30 |
Abdominal pain | severe Disc. AE |
30 mL single, oral Overdose |
healthy, 30 |
Enterocolitis | severe Disc. AE |
30 mL single, oral Overdose |
healthy, 30 |
Erosive oesophagitis | severe Disc. AE |
30 mL single, oral Overdose |
healthy, 30 |
Gastritis erosive | severe Disc. AE |
30 mL single, oral Overdose |
healthy, 30 |
Respiratory depression | severe Disc. AE |
30 mL single, oral Overdose |
healthy, 30 |
Ulceration | severe Disc. AE |
30 mL single, oral Overdose |
healthy, 30 |
Cardiac arrhythmias | grade 5 Disc. AE |
73 g/m3 single, respiratory Recommended Dose: 73 g/m3 Route: respiratory Route: single Dose: 73 g/m3 Sources: |
unknown |
Cardiac failure | grade 5 Disc. AE |
73 g/m3 single, respiratory Recommended Dose: 73 g/m3 Route: respiratory Route: single Dose: 73 g/m3 Sources: |
unknown |
Respiratory failure | grade 5 Disc. AE |
73 g/m3 single, respiratory Recommended Dose: 73 g/m3 Route: respiratory Route: single Dose: 73 g/m3 Sources: |
unknown |
Dizziness | Disc. AE | 1030 ppm single, respiratory Studied dose Dose: 1030 ppm Route: respiratory Route: single Dose: 1030 ppm Sources: |
healthy |
Headache | Disc. AE | 1030 ppm single, respiratory Studied dose Dose: 1030 ppm Route: respiratory Route: single Dose: 1030 ppm Sources: |
healthy |
Intracranial pressure increase | Disc. AE | 1030 ppm single, respiratory Studied dose Dose: 1030 ppm Route: respiratory Route: single Dose: 1030 ppm Sources: |
healthy |
Nausea | Disc. AE | 1030 ppm single, respiratory Studied dose Dose: 1030 ppm Route: respiratory Route: single Dose: 1030 ppm Sources: |
healthy |
PubMed
Title | Date | PubMed |
---|---|---|
7Li-NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution. | 2001 |
|
Purification and characterization of catalase from chard (Beta vulgaris var. cicla). | 2001 |
|
Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone. | 2001 |
|
Incidence of seed-borne fungi and aflatoxins in Sudanese lentil seeds. | 2001 |
|
Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus. | 2001 |
|
Plasma lipases and lipid transfer proteins increase phospholipid but not free cholesterol transfer from lipid emulsion to high density lipoproteins. | 2001 |
|
[New studies on the history of anesthesiology--(7). What anesthetics were given to soldiers of the fifth regiment rescued from death march on Mount Hakkoda?]. | 2001 Apr |
|
Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E. | 2001 Apr |
|
Determination of ochratoxin A in red wine and vinegar by immunoaffinity high-pressure liquid chromatography. | 2001 Apr |
|
Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells. | 2001 Apr |
|
First isolation and characterization of eight regioisomers for [60]fullerene-benzene bisadducts. | 2001 Apr 19 |
|
Synthesis and self-aggregation of cyclic alkynes containing helicene. | 2001 Apr 19 |
|
Anesthetic-like interactions of nitric oxide with albumin and hemeproteins. A mechanism for control of protein function. | 2001 Apr 27 |
|
Influence of N-terminal residue stereochemistry on the prolyl amide geometry and the conformation of 5-tert-butylproline type VI beta-turn mimics. | 2001 Feb |
|
A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors. | 2001 Feb |
|
DNA isolation from chloroform/methanol-treated mycobacterial cells without lysozyme and proteinase K. | 2001 Feb |
|
Antibacterial activity of Punica granatum. | 2001 Feb |
|
Antibacterial activity of Barringtonia racemosa. | 2001 Feb |
|
Carbon tetrachloride dechlorination by the bacterial transition metal chelator pyridine-2,6-bis(thiocarboxylic acid). | 2001 Feb 1 |
|
Reductive dechlorination of cis-1,2-dichloroethene and vinyl chloride by "Dehalococcoides ethenogenes". | 2001 Feb 1 |
|
Correlation of a specific mitochondrial phospholipid-phosgene adduct with chloroform acute toxicity. | 2001 Feb 21 |
|
Understanding the role of internal lysine residues of serum albumins in conformational stability and bilirubin binding. | 2001 Feb 9 |
|
Hazardous air pollutants formation from reactions of raw meal organics in cement kilns. | 2001 Feb-Mar |
|
Formation and decomposition of chloroaromatic compounds in chlorine-containing benzene/oxygen flames. | 2001 Feb-Mar |
|
Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation. | 2001 Jan |
|
Direct measurements of hemoglobin interactions with liposomes using EPR spectroscopy. | 2001 Jan |
|
Phenylisoserine: a versatile amino acid for the construction of novel beta-peptide structures. | 2001 Jan 10 |
|
Monthly variations in diarrhetic toxins and yessotoxin in shellfish from coast to the inner part of the Sognefjord, Norway. | 2001 Jul |
|
Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function. | 2001 Jul 6 |
|
Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts. | 2001 Jun 5 |
|
Extraction of iridium (IV) from hydrochloric acid media with crown ether in chloroform, and its determination by ICP-AES. | 2001 Mar |
|
A new spectrophotometric method for the determination of total and ferric iron in rain water at the ppb level. | 2001 Mar |
|
Efficiency of rice bran for removal of organochlorine compounds and benzene from industrial wastewater. | 2001 Mar |
|
Molecular mechanisms of anesthesia. | 2001 Mar |
|
Isolation of genomic DNA from feathers. | 2001 Mar |
|
Transient absorption from the 1Bu+ state of all-trans-beta-carotene newly identified in the near-infrared region. | 2001 Mar |
|
Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts. | 2001 Mar 14 |
|
Evidence for a common binding cavity for three general anesthetics within the GABAA receptor. | 2001 Mar 15 |
|
Antiimplantation and pregnancy interruption efficacy of Rivea hypocrateriformis in the rat. | 2001 Mar 3 |
|
Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity. | 2001 May |
|
A controlled field experiment on groundwater contamination by a multicomponent DNAPL: creation of the emplaced-source and overview of dissolved plume development. | 2001 May |
|
Cytotoxic activity of Typhonium flagelliforme (Araceae). | 2001 May |
|
Improved method for the recovery of hepatitis A virus from oysters. | 2001 May |
|
Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water. | 2001 May |
|
An improved method for isolation of unconjugated bilirubin from rat and dog bile. | 2001 May |
|
Measurement of potency and lipids in monensin fermentation broth by near-infrared spectroscopy. | 2001 May |
|
Sequence specificity of hydrogen-bonded molecular duplexes. | 2001 May 18 |
|
Evaluation of diimine ligand exchange on Cu(I). | 2001 May 21 |
|
Rigorous interpretation of electronic density functions of axial and equatorial conformers of dimethylphosphinoylcyclohexane, 2-(dimethylphosphinoyl)-1,3,5-trithiane, and 2-(dimethylphosphinoyl)-1,3-dithiane-1,1,3,3-tetraoxide. | 2001 May 4 |
|
Lipase catalyzed synthesis of organic acid esters of lactic acid in non-aqueous media. | 2001 May 4 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:48:35 GMT 2025
by
admin
on
Mon Mar 31 17:48:35 GMT 2025
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Record UNII |
7V31YC746X
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
20701
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WHO-VATC |
QN01AB02
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NCI_THESAURUS |
C45386
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IARC | Chloroform | ||
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WHO-ATC |
N01AB02
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CFR |
21 CFR 310.502
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CFR |
21 CFR 216.24
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CFR |
21 CFR 700.18
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Code System | Code | Type | Description | ||
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35255
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PRIMARY | |||
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67-66-3
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200-663-8
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4363
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1601383
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56
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C45678
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CONCEPT | Industrial Aid | ||
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m3412
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PRIMARY | Merck Index | ||
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CHEMBL44618
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DTXSID1020306
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SUB13331MIG
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77361
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SUB13333MIG
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ALTERNATIVE | |||
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C29815
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D002725
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1362698
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6212
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7V31YC746X
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100000080074
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chloroform
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7V31YC746X
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CHLOROFORM
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DB11387
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SUB29129
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PRIMARY |
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PARENT -> IMPURITY |
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USP
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ACTIVE MOIETY |
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