U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CHCl3
Molecular Weight 119.3775
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLOROFORM

SMILES

C(Cl)(Cl)Cl

InChI

InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N
InChI=1S/CHCl3/c2-1(3)4/h1H

HIDE SMILES / InChI

Molecular Formula CHCl3
Molecular Weight 119.3775
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Chloroform is a colorless, sweet-smelling, dense liquid and widely used industrial and laboratory solvent. The total global flux of chloroform through the environment is approximately 660 000 tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Chloroform is used as an industrial solvent and as an intermediate in the manufacture of polymeric materials. The major use of chloroformtoday is in the production of the refrigerant R-22, commonly used in the air conditioning business. Inhaled chloroform anesthesia was introduced in 1847 and Chloroform subsequently became the most widely used volatile anaesthetic, and was used in horses before the end of the 19th century. Pure chloroform is known to be decomposed by the air with the formation of hydrochloric acid, phosgene and carbon dioxide. Phosgene is also generated metabolically from chloroform, and liver and kidney damage can ensue from its production.

Approval Year

AUC

AUC

ValueDoseCo-administeredAnalytePopulation
176 μg × min/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: FEMALE
food status: UNKNOWN
293 μg × min/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
86 min
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: FEMALE
food status: UNKNOWN
96 min
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Disc. AE: Loss of consciousness, Hypotension...
AEs leading to
discontinuation/dose reduction:
Loss of consciousness
Hypotension
Respiratory depression (severe)
Abdominal pain (severe)
Vomiting
Diarrhea
Enterocolitis (severe)
Erosive oesophagitis (severe)
Gastritis erosive (severe)
Ulceration (severe)
Contact dermatitis
ALT increased
AST increased
Sources: Page: p.1,2
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Disc. AE: Respiratory failure, Cardiac arrhythmias...
AEs leading to
discontinuation/dose reduction:
Respiratory failure (grade 5)
Cardiac arrhythmias (grade 5)
Cardiac failure (grade 5)
Sources: Page: p.26
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Disc. AE: Dizziness, Intracranial pressure increase...
AEs leading to
discontinuation/dose reduction:
Dizziness
Intracranial pressure increase
Nausea
Headache
Sources:
AEs

AEs

AESignificanceDosePopulation
ALT increased Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
AST increased Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Contact dermatitis Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Diarrhea Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Hypotension Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Loss of consciousness Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Vomiting Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Abdominal pain severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Enterocolitis severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Erosive oesophagitis severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Gastritis erosive severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Respiratory depression severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Ulceration severe
Disc. AE
30 mL single, oral (max)
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources: Page: p.1,2
healthy, 30
n = 1
Health Status: healthy
Age Group: 30
Sex: F
Population Size: 1
Sources: Page: p.1,2
Cardiac arrhythmias grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Cardiac failure grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Respiratory failure grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources: Page: p.26
unknown
Health Status: unknown
Condition: anaesthesia
Sources: Page: p.26
Dizziness Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Headache Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Intracranial pressure increase Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Nausea Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as victimTox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
7Li-NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution.
2001
Purification and characterization of catalase from chard (Beta vulgaris var. cicla).
2001
Inhibition of spontaneous induction of lambdoid prophages in Escherichia coli cultures: simple procedures with possible biotechnological applications.
2001
Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone.
2001
Incidence of seed-borne fungi and aflatoxins in Sudanese lentil seeds.
2001
Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus.
2001
[New studies on the history of anesthesiology--(7). What anesthetics were given to soldiers of the fifth regiment rescued from death march on Mount Hakkoda?].
2001 Apr
Labdane and pimarane diterpenes from Croton joufra.
2001 Apr
Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E.
2001 Apr
Determination of ochratoxin A in red wine and vinegar by immunoaffinity high-pressure liquid chromatography.
2001 Apr
Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells.
2001 Apr
The Bacillus subtilis yabQ gene is essential for formation of the spore cortex.
2001 Apr
First isolation and characterization of eight regioisomers for [60]fullerene-benzene bisadducts.
2001 Apr 19
Synthesis and self-aggregation of cyclic alkynes containing helicene.
2001 Apr 19
Anesthetic-like interactions of nitric oxide with albumin and hemeproteins. A mechanism for control of protein function.
2001 Apr 27
Long-term follow-up on keratocysts treated according to a defined protocol.
2001 Feb
Influence of N-terminal residue stereochemistry on the prolyl amide geometry and the conformation of 5-tert-butylproline type VI beta-turn mimics.
2001 Feb
Carbon tetrachloride dechlorination by the bacterial transition metal chelator pyridine-2,6-bis(thiocarboxylic acid).
2001 Feb 1
Reductive dechlorination of cis-1,2-dichloroethene and vinyl chloride by "Dehalococcoides ethenogenes".
2001 Feb 1
Fluorometric method for the simultaneous quantitation of differently-sized nanoparticles in rodent tissue.
2001 Feb 19
Understanding the role of internal lysine residues of serum albumins in conformational stability and bilirubin binding.
2001 Feb 9
Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation.
2001 Jan
Direct measurements of hemoglobin interactions with liposomes using EPR spectroscopy.
2001 Jan
Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function.
2001 Jul 6
Extraction of iridium (IV) from hydrochloric acid media with crown ether in chloroform, and its determination by ICP-AES.
2001 Mar
A new spectrophotometric method for the determination of total and ferric iron in rain water at the ppb level.
2001 Mar
Efficiency of rice bran for removal of organochlorine compounds and benzene from industrial wastewater.
2001 Mar
The role of nitric oxide on cigarette smoke-induced programmed cell death in the gastric mucosa.
2001 Mar
Biosynthesis of PHB tercopolymer by Bacillus cereus UW85.
2001 Mar
Molecular mechanisms of anesthesia.
2001 Mar
Mast cell stabilising activity of Bacopa monnieri.
2001 Mar
Isolation of genomic DNA from feathers.
2001 Mar
Transient absorption from the 1Bu+ state of all-trans-beta-carotene newly identified in the near-infrared region.
2001 Mar
Photochemistry of the pi-extended 9,10-bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene system: generation and characterisation of the radical cation, dication, and derived products.
2001 Mar 2
Antiimplantation and pregnancy interruption efficacy of Rivea hypocrateriformis in the rat.
2001 Mar 3
Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity.
2001 May
A controlled field experiment on groundwater contamination by a multicomponent DNAPL: creation of the emplaced-source and overview of dissolved plume development.
2001 May
Cytotoxic activity of Typhonium flagelliforme (Araceae).
2001 May
Improved method for the recovery of hepatitis A virus from oysters.
2001 May
Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water.
2001 May
An improved method for isolation of unconjugated bilirubin from rat and dog bile.
2001 May
Evaluation of extraction methods from paraffin wax embedded tissues for PCR amplification of human and viral DNA.
2001 May
Screening of various Swertia species extracts in primary monolayer cultures of rat hepatocytes against carbon tetrachloride- and paracetamol-induced toxicity.
2001 May
Bactericidal properties of the chloroform fraction from rhizomes of Aristolochia paucinervis Pomel.
2001 May
Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid.
2001 May
Measurement of potency and lipids in monensin fermentation broth by near-infrared spectroscopy.
2001 May
Sequence specificity of hydrogen-bonded molecular duplexes.
2001 May 18
Evaluation of diimine ligand exchange on Cu(I).
2001 May 21
Rigorous interpretation of electronic density functions of axial and equatorial conformers of dimethylphosphinoylcyclohexane, 2-(dimethylphosphinoyl)-1,3,5-trithiane, and 2-(dimethylphosphinoyl)-1,3-dithiane-1,1,3,3-tetraoxide.
2001 May 4
Lipase catalyzed synthesis of organic acid esters of lactic acid in non-aqueous media.
2001 May 4
Substance Class Chemical
Created
by admin
on Sat Jun 26 12:06:08 UTC 2021
Edited
by admin
on Sat Jun 26 12:06:08 UTC 2021
Record UNII
7V31YC746X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLOROFORM
GREEN BOOK   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
CHLOROFORM [GREEN BOOK]
Common Name English
CHLOROFORM [USP-RS]
Common Name English
CHLOROFORM [MART.]
Common Name English
CHLOROFORM [II]
Common Name English
CHLOROFORM [MI]
Common Name English
NSC-77361
Code English
CHLOROFORM [VANDF]
Common Name English
HCC 20
Common Name English
CHLOROBUTANOL IMPURITY A [EP]
Common Name English
CHLOROFORM [HSDB]
Common Name English
CHLOROFORM BP
Common Name English
CHLOROFORM [WHO-DD]
Common Name English
CHLOROFORM [INCI]
Common Name English
R 20 (REFRIGERANT)
Common Name English
METHANE, TRICHLORO-
Systematic Name English
TRICHLOROMETHANE
Systematic Name English
CHLOROFORMUM [HPUS]
Common Name English
CHLOROFORM [IARC]
Common Name English
CHLOROFORMUM
HPUS  
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 20701
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
WHO-VATC QN01AB02
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
NCI_THESAURUS C45386
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
IARC Chloroform
WHO-ATC N01AB02
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
CFR 21 CFR 310.502
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
CFR 21 CFR 700.18
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
Code System Code Type Description
CAS
67-66-3
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-663-8
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
DRUG CENTRAL
4363
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
HSDB
56
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
CONCEPT Industrial Aid
MERCK INDEX
M3412
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY Merck Index
ChEMBL
CHEMBL44618
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
EPA CompTox
67-66-3
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
EVMPD
SUB13331MIG
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
EVMPD
SUB13333MIG
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
ALTERNATIVE
NCI_THESAURUS
C29815
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
MESH
D002725
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
USP_CATALOG
1601383
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY USP-RS
RXCUI
1362698
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY RxNorm
PUBCHEM
6212
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
FDA UNII
7V31YC746X
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
WIKIPEDIA
CHLOROFORM
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
DRUG BANK
DB11387
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
EVMPD
SUB29129
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
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