U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CHCl3
Molecular Weight 119.3775
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLOROFORM

SMILES

C(Cl)(Cl)Cl

InChI

InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N
InChI=1S/CHCl3/c2-1(3)4/h1H

HIDE SMILES / InChI

Molecular Formula CHCl3
Molecular Weight 119.3775
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Chloroform is a colorless, sweet-smelling, dense liquid and widely used industrial and laboratory solvent. The total global flux of chloroform through the environment is approximately 660 000 tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Chloroform is used as an industrial solvent and as an intermediate in the manufacture of polymeric materials. The major use of chloroformtoday is in the production of the refrigerant R-22, commonly used in the air conditioning business. Inhaled chloroform anesthesia was introduced in 1847 and Chloroform subsequently became the most widely used volatile anaesthetic, and was used in horses before the end of the 19th century. Pure chloroform is known to be decomposed by the air with the formation of hydrochloric acid, phosgene and carbon dioxide. Phosgene is also generated metabolically from chloroform, and liver and kidney damage can ensue from its production.

Approval Year

AUC

AUC

ValueDoseCo-administeredAnalytePopulation
176 μg × min/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: FEMALE
food status: UNKNOWN
293 μg × min/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
86 min
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: FEMALE
food status: UNKNOWN
96 min
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CHLOROFORM blood
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Disc. AE: Loss of consciousness, Hypotension...
AEs leading to
discontinuation/dose reduction:
Loss of consciousness
Hypotension
Respiratory depression (severe)
Abdominal pain (severe)
Vomiting
Diarrhea
Enterocolitis (severe)
Erosive oesophagitis (severe)
Gastritis erosive (severe)
Ulceration (severe)
Contact dermatitis
ALT increased
AST increased
Sources:
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources:
unknown
Disc. AE: Respiratory failure, Cardiac arrhythmias...
AEs leading to
discontinuation/dose reduction:
Respiratory failure (grade 5)
Cardiac arrhythmias (grade 5)
Cardiac failure (grade 5)
Sources:
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Disc. AE: Dizziness, Intracranial pressure increase...
AEs leading to
discontinuation/dose reduction:
Dizziness
Intracranial pressure increase
Nausea
Headache
Sources:
AEs

AEs

AESignificanceDosePopulation
ALT increased Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
AST increased Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Contact dermatitis Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Diarrhea Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Hypotension Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Loss of consciousness Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Vomiting Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Abdominal pain severe
Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Enterocolitis severe
Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Erosive oesophagitis severe
Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Gastritis erosive severe
Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Respiratory depression severe
Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Ulceration severe
Disc. AE
30 mL single, oral
Overdose
Dose: 30 mL
Route: oral
Route: single
Dose: 30 mL
Sources:
healthy, 30
Health Status: healthy
Age Group: 30
Sex: F
Sources:
Cardiac arrhythmias grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources:
unknown
Cardiac failure grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources:
unknown
Respiratory failure grade 5
Disc. AE
73 g/m3 single, respiratory
Recommended
Dose: 73 g/m3
Route: respiratory
Route: single
Dose: 73 g/m3
Sources:
unknown
Dizziness Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Headache Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Intracranial pressure increase Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Nausea Disc. AE
1030 ppm single, respiratory
Studied dose
Dose: 1030 ppm
Route: respiratory
Route: single
Dose: 1030 ppm
Sources:
healthy
Health Status: healthy
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as victimTox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Herpes zoster and post-herpetic neuralgia--a clinical trial of aspirin in chloroform for anodyne.
1998 Apr
Inhibition of spontaneous induction of lambdoid prophages in Escherichia coli cultures: simple procedures with possible biotechnological applications.
2001
Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone.
2001
Incidence of seed-borne fungi and aflatoxins in Sudanese lentil seeds.
2001
Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus.
2001
Labdane and pimarane diterpenes from Croton joufra.
2001 Apr
Determination of ochratoxin A in red wine and vinegar by immunoaffinity high-pressure liquid chromatography.
2001 Apr
Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells.
2001 Apr
Inhibiting effects of chloroform on anaerobic microbial consortia as monitored by the Rantox biosensor.
2001 Apr
First isolation and characterization of eight regioisomers for [60]fullerene-benzene bisadducts.
2001 Apr 19
Synthesis and self-aggregation of cyclic alkynes containing helicene.
2001 Apr 19
Anesthetic-like interactions of nitric oxide with albumin and hemeproteins. A mechanism for control of protein function.
2001 Apr 27
Influence of N-terminal residue stereochemistry on the prolyl amide geometry and the conformation of 5-tert-butylproline type VI beta-turn mimics.
2001 Feb
Oxidative degradation study of nitrendipine using stability indicating, HPLC, HPTLC and spectrophotometric method.
2001 Feb
DNA isolation from chloroform/methanol-treated mycobacterial cells without lysozyme and proteinase K.
2001 Feb
Antibacterial activity of Punica granatum.
2001 Feb
Carbon tetrachloride dechlorination by the bacterial transition metal chelator pyridine-2,6-bis(thiocarboxylic acid).
2001 Feb 1
Reductive dechlorination of cis-1,2-dichloroethene and vinyl chloride by "Dehalococcoides ethenogenes".
2001 Feb 1
Fluorometric method for the simultaneous quantitation of differently-sized nanoparticles in rodent tissue.
2001 Feb 19
Correlation of a specific mitochondrial phospholipid-phosgene adduct with chloroform acute toxicity.
2001 Feb 21
Understanding the role of internal lysine residues of serum albumins in conformational stability and bilirubin binding.
2001 Feb 9
Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation.
2001 Jan
Phenylisoserine: a versatile amino acid for the construction of novel beta-peptide structures.
2001 Jan 10
Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function.
2001 Jul 6
Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts.
2001 Jun 5
Extraction of iridium (IV) from hydrochloric acid media with crown ether in chloroform, and its determination by ICP-AES.
2001 Mar
Efficiency of rice bran for removal of organochlorine compounds and benzene from industrial wastewater.
2001 Mar
Biosynthesis of PHB tercopolymer by Bacillus cereus UW85.
2001 Mar
Transient absorption from the 1Bu+ state of all-trans-beta-carotene newly identified in the near-infrared region.
2001 Mar
Anion recognition by thiostrepton.
2001 Mar 12
Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts.
2001 Mar 14
Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.
2001 Mar 15
Photochemistry of the pi-extended 9,10-bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene system: generation and characterisation of the radical cation, dication, and derived products.
2001 Mar 2
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.
2001 Mar 23
Chloroform-soluble schiff-base Zn(II) or Cd(II) complexes from a dynamic combinatorial library.
2001 Mar 26
Antiimplantation and pregnancy interruption efficacy of Rivea hypocrateriformis in the rat.
2001 Mar 3
Synthesis, aggregation, and binding behavior of synthetic amphiphilic receptors.
2001 Mar 9
Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity.
2001 May
A controlled field experiment on groundwater contamination by a multicomponent DNAPL: creation of the emplaced-source and overview of dissolved plume development.
2001 May
Cytotoxic activity of Typhonium flagelliforme (Araceae).
2001 May
Improved method for the recovery of hepatitis A virus from oysters.
2001 May
Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water.
2001 May
An improved method for isolation of unconjugated bilirubin from rat and dog bile.
2001 May
Evaluation of extraction methods from paraffin wax embedded tissues for PCR amplification of human and viral DNA.
2001 May
Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid.
2001 May
Measurement of potency and lipids in monensin fermentation broth by near-infrared spectroscopy.
2001 May
Sequence specificity of hydrogen-bonded molecular duplexes.
2001 May 18
Evaluation of diimine ligand exchange on Cu(I).
2001 May 21
Rigorous interpretation of electronic density functions of axial and equatorial conformers of dimethylphosphinoylcyclohexane, 2-(dimethylphosphinoyl)-1,3,5-trithiane, and 2-(dimethylphosphinoyl)-1,3-dithiane-1,1,3,3-tetraoxide.
2001 May 4
Lipase catalyzed synthesis of organic acid esters of lactic acid in non-aqueous media.
2001 May 4
Substance Class Chemical
Created
by admin
on Sat Jun 26 12:06:08 UTC 2021
Edited
by admin
on Sat Jun 26 12:06:08 UTC 2021
Record UNII
7V31YC746X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLOROFORM
GREEN BOOK   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
CHLOROFORM [GREEN BOOK]
Common Name English
CHLOROFORM [USP-RS]
Common Name English
CHLOROFORM [MART.]
Common Name English
CHLOROFORM [II]
Common Name English
CHLOROFORM [MI]
Common Name English
NSC-77361
Code English
CHLOROFORM [VANDF]
Common Name English
HCC 20
Common Name English
CHLOROBUTANOL IMPURITY A [EP]
Common Name English
CHLOROFORM [HSDB]
Common Name English
CHLOROFORM BP
Common Name English
CHLOROFORM [WHO-DD]
Common Name English
CHLOROFORM [INCI]
Common Name English
R 20 (REFRIGERANT)
Common Name English
METHANE, TRICHLORO-
Systematic Name English
TRICHLOROMETHANE
Systematic Name English
CHLOROFORMUM [HPUS]
Common Name English
CHLOROFORM [IARC]
Common Name English
CHLOROFORMUM
HPUS  
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 20701
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
WHO-VATC QN01AB02
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
NCI_THESAURUS C45386
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
IARC Chloroform
WHO-ATC N01AB02
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
CFR 21 CFR 310.502
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
CFR 21 CFR 700.18
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
Code System Code Type Description
CAS
67-66-3
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-663-8
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
DRUG CENTRAL
4363
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
HSDB
56
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
CONCEPT Industrial Aid
MERCK INDEX
M3412
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY Merck Index
ChEMBL
CHEMBL44618
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
EPA CompTox
67-66-3
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
EVMPD
SUB13331MIG
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
EVMPD
SUB13333MIG
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
ALTERNATIVE
NCI_THESAURUS
C29815
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
MESH
D002725
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
USP_CATALOG
1601383
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY USP-RS
RXCUI
1362698
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY RxNorm
PUBCHEM
6212
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
FDA UNII
7V31YC746X
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
WIKIPEDIA
CHLOROFORM
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
DRUG BANK
DB11387
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
EVMPD
SUB29129
Created by admin on Sat Jun 26 12:06:09 UTC 2021 , Edited by admin on Sat Jun 26 12:06:09 UTC 2021
PRIMARY
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