DESFLURANE

Details

Stereochemistry	RACEMIC
Molecular Formula	C3H2F6O
Molecular Weight	168.0379
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C(C(F)(F)F)(F)OC(F)F

InChI

InChIKey=DPYMFVXJLLWWEU-UHFFFAOYSA-N

InChI=1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30725791 | https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020118s024lbl.pdf

Desflurane is a non-flammable liquid administered via vaporizer as a general anesthetic. It is halogenated exclusively with fluorine and is very resistant to defluorination. For this reason, it is not associated with nephrotoxicity, as is the case with other inhalational anesthetics. Desflurane is indicated for the induction and/or maintenance of anesthesia and adults, and for maintenance of anesthesia in pediatric patients following the induction with other agents.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
skeletal muscle relaxation 7 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020118s024lbl.pdf	Primary		Approved 8043	SUPRANE Approved Use Suprane is an inhalation agent indicated for induction and/or maintenance of anesthesia in adults, for maintenance of anesthesia in pediatric patients following induction with agents other than Suprane (desflurane, USP) and intubation. Launch Date 7.1677438E11

Doses

Dose	Population	Adverse events
0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: https://www.fda.gov/media/92113/download	unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: https://www.fda.gov/media/92113/download	Other AEs: Airways obstruction, Breath holding... Other AEs: Airways obstruction (4%) Breath holding (3%) Bronchospasm (1%) Coughing (26%) Hiccups (1%) Laryngospasm (13%) Sources: https://www.fda.gov/media/92113/download

AEs

AE	Significance	Dose	Population
Bronchospasm	1%	0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: https://www.fda.gov/media/92113/download	unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: https://www.fda.gov/media/92113/download
Hiccups	1%	0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: https://www.fda.gov/media/92113/download	unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: https://www.fda.gov/media/92113/download
Laryngospasm	13%	0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: https://www.fda.gov/media/92113/download	unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: https://www.fda.gov/media/92113/download
Coughing	26%	0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: https://www.fda.gov/media/92113/download	unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: https://www.fda.gov/media/92113/download
Breath holding	3%	0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: https://www.fda.gov/media/92113/download	unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: https://www.fda.gov/media/92113/download
Airways obstruction	4%	0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: https://www.fda.gov/media/92113/download	unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: https://www.fda.gov/media/92113/download

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
Kv1.5 25	CYP2E1 606

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
Kv1.5 40	inhibitor 3045 Sources: https://pubmed.ncbi.nlm.nih.gov/32436224/	yes

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2E1 606	substrate 3113 Sources: https://pubmed.ncbi.nlm.nih.gov/19442086/ \| https://pubmed.ncbi.nlm.nih.gov/8214760/	likely

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:4445	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4445
ChemicalBook	CB2304120	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB2304120
eMolecules	907267	https://www.emolecules.com/cgi-bin/more?vid=907267

PubMed

Title	Date	PubMed
Comparison of the influence of desflurane nitrous oxide anesthesia to propofol nitrous oxide anesthesia on rocuronium bromide induced neuromuscular block.	2001	11732388
A survey on anesthesia for thoracoscopic sympathetic surgery in treatment of hyperhidrosis palmaris in Taiwan.	2001	11695798
Use of remifentanil in combination with desflurane or propofol for ambulatory oral surgery.	2001	11534310
Use of intravenous opioids to reduce airway irritation during induction of anaesthesia with desflurane.	2001 Apr	11573648
Volatile anesthetics give a false-positive reading in chemical agent monitors in the "H" mode.	2001 Aug	11515322
Effects of desflurane and sevoflurane on length-dependent regulation of myocardial function in coronary surgery patients.	2001 Aug	11506106
Prevention of PONV with dexamethasone in female patients undergoing desflurane anesthesia for thyroidectomy.	2001 Dec	11840580
EEG complexity as a measure of depth of anesthesia for patients.	2001 Dec	11759923
The recovery of cognitive function after general anesthesia in elderly patients: a comparison of desflurane and sevoflurane.	2001 Dec	11726429
The effects of increasing concentrations of isoflurane and desflurane on pulmonary perfusion and systemic oxygenation during one-lung ventilation in pigs.	2001 Dec	11726419
Integrated analysis of protein and glucose metabolism during surgery: effects of anesthesia.	2001 Dec	11717214
Effects of different concentrations of sevoflurane and desflurane on subcortical somatosensory evoked responses in anaesthetized, non-stimulated patients.	2001 Jan	11575411
Recovery and neurological examination after remifentanil-desflurane or fentanyl-desflurane anaesthesia for carotid artery surgery.	2001 Jan	11575408
Model-based administration of inhalation anaesthesia. 2. Exploring the system model.	2001 Jan	11575406
Intravenous opioids reduce airway irritation during induction of anaesthesia with desflurane in adults.	2001 Jan	11575399
Model-based administration of inhalation anaesthesia. 1. Developing a system model.	2001 Jan	11575385
A case report of a fractured healthytooth during use of Guedel oropharyngeal airway.	2001 Jul	11599628
Prediction of volatile anaesthetic solubility in blood and priming fluids for extracorporeal circulation.	2001 Mar	11573521
Inhalation anaesthetics increase heart rate by decreasing cardiac vagal activity in dogs.	2001 Nov	11878527
Carbon monoxide production from desflurane, enflurane, halothane, isoflurane, and sevoflurane with dry soda lime.	2001 Nov	11684991
Viscosity and density of common anaesthetic gases: implications for flow measurements.	2001 Oct	11878731
Measuring the costs of inhaled anaesthetics.	2001 Oct	11878724
Blood solubilities of volatile anesthetics in cardiac patients.	2001 Oct	11687994
Dynamic changes in blood solubility of desflurane, isoflurane, and halothane during cardiac surgery.	2001 Oct	11687993
[The effect of propofol vs desflurane on recovery from anesthesia with remifentanil in outpatient surgery].	2001 Oct	11674983
Goal oriented general anesthesia for Cesarean section in a parturient with a large intracranial epidermoid cyst.	2001 Oct	11606346
Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs.	2001 Oct	11605939
Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations.	2001 Oct	11605938
[Alternatives to nitrous oxide-desflurane].	2001 Oct	11592028
200 years of nitrous oxide (laughing gas)--and the end of an era?	2001 Oct	11592024
Oxidative stress status during exposure to propofol, sevoflurane and desflurane.	2001 Oct	11574369
The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene.	2001 Oct	11574358
Prolonged anesthesia with desflurane and fentanyl in dogs during conventional and laparoscopic surgery.	2001 Oct 1	11601789
Desflurane, sevoflurane, and isoflurane affect left atrial active and passive mechanical properties and impair left atrial-left ventricular coupling in vivo: analysis using pressure-volume relations.	2001 Sep	11575543
Sub-MAC concentrations of desflurane do not inhibit hypoxic pulmonary vasoconstriction in anesthetized piglets.	2001 Sep	11546716
The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral position.	2002 Apr	11916816
Phantom anaesthetic vapour.	2002 Feb	11871975
Effects of desflurane and isoflurane on intestinal tissue oxygen pressure during colorectal surgery.	2002 Feb	11871946
Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement.	2002 Feb	11818761
Small-dose selective spinal anesthesia for short-duration outpatient laparoscopy: recovery characteristics compared with desflurane anesthesia.	2002 Feb	11812696
Anaesthetic agents in paediatric day case surgery: do they affect outcome?	2002 Jan	11913809
Model-based administration of inhalation anaesthesia. 3. Validating the system model.	2002 Jan	11883376
Fresh gas flow is not the only determinant of volatile agent consumption: a multi-centre study of low-flow anaesthesia.	2002 Jan	11881883
Effects of desflurane on jugular bulb gases and pressure in neurosurgical patients.	2002 Jan	11773817
The assessment of postural stability after ambulatory anesthesia: a comparison of desflurane with propofol.	2002 Jan	11772801
Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.	2002 Jan	11753018
Subcellular localization of trifluoroacetylated liver proteins in association with hepatitis following isoflurane.	2002 Mar	11873055
The relationship between acceleromyographic train-of-four fade and single twitch depression.	2002 Mar	11873031
Selective spinal anesthesia versus desflurane anesthesia in short duration outpatient gynecological laparoscopy: a pharmacoeconomic comparison.	2002 Mar	11867376
Fast-track eligibility of geriatric patients undergoing short urologic surgery procedures.	2002 Mar	11867375

Name

Type

Language

DESFLURANE

Official Name

English

DESFLURANE [INN]

Common Name

English

I-653

Code

English

DESFLURANE [USAN]

Common Name

English

DESFLURANE [VANDF]

Common Name

English

ETHANE, 2-(DIFLUOROMETHOXY)-1,1,1,2-TETRAFLUORO-, (+/-)-

Systematic Name

English

DESFLURANE [USP MONOGRAPH]

Common Name

English

DESFLURANE [ORANGE BOOK]

Common Name

English

DESFLURANE [USP-RS]

Common Name

English

DESFLURANE [JAN]

Common Name

English

(+/-)-2-DIFLUOROMETHYL 1,2,2,2-TETRAFLUOROETHYL ETHER

Common Name

English

DESFLURANE [WHO-DD]

Common Name

English

SUPRANE

Brand Name

English

DESFLURANE [EP MONOGRAPH]

Common Name

English

DESFLURANE [MI]

Common Name

English

DESFLURANE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

N01AB07