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Details

Stereochemistry RACEMIC
Molecular Formula C3H2F6O
Molecular Weight 168.0379
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DESFLURANE

SMILES

C(C(F)(F)F)(F)OC(F)F

InChI

InChIKey=DPYMFVXJLLWWEU-UHFFFAOYSA-N
InChI=1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H

HIDE SMILES / InChI
Desflurane is a non-flammable liquid administered via vaporizer as a general anesthetic. It is halogenated exclusively with fluorine and is very resistant to defluorination. For this reason, it is not associated with nephrotoxicity, as is the case with other inhalational anesthetics. Desflurane is indicated for the induction and/or maintenance of anesthesia and adults, and for maintenance of anesthesia in pediatric patients following the induction with other agents.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SUPRANE

Approved Use

Suprane is an inhalation agent indicated for induction and/or maintenance of anesthesia in adults, for maintenance of anesthesia in pediatric patients following induction with agents other than Suprane (desflurane, USP) and intubation.

Launch Date

7.1677438E11
Doses

Doses

DosePopulationAdverse events​
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Other AEs: Airways obstruction, Breath holding...
Other AEs:
Airways obstruction (4%)
Breath holding (3%)
Bronchospasm (1%)
Coughing (26%)
Hiccups (1%)
Laryngospasm (13%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Bronchospasm 1%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Hiccups 1%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Laryngospasm 13%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Coughing 26%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Breath holding 3%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Airways obstruction 4%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
Drug as victim

Drug as victim

PubMed

PubMed

TitleDatePubMed
Comparison of the influence of desflurane nitrous oxide anesthesia to propofol nitrous oxide anesthesia on rocuronium bromide induced neuromuscular block.
2001
A survey on anesthesia for thoracoscopic sympathetic surgery in treatment of hyperhidrosis palmaris in Taiwan.
2001
Use of remifentanil in combination with desflurane or propofol for ambulatory oral surgery.
2001
Use of intravenous opioids to reduce airway irritation during induction of anaesthesia with desflurane.
2001 Apr
Volatile anesthetics give a false-positive reading in chemical agent monitors in the "H" mode.
2001 Aug
Effects of desflurane and sevoflurane on length-dependent regulation of myocardial function in coronary surgery patients.
2001 Aug
Prevention of PONV with dexamethasone in female patients undergoing desflurane anesthesia for thyroidectomy.
2001 Dec
EEG complexity as a measure of depth of anesthesia for patients.
2001 Dec
The recovery of cognitive function after general anesthesia in elderly patients: a comparison of desflurane and sevoflurane.
2001 Dec
The effects of increasing concentrations of isoflurane and desflurane on pulmonary perfusion and systemic oxygenation during one-lung ventilation in pigs.
2001 Dec
Integrated analysis of protein and glucose metabolism during surgery: effects of anesthesia.
2001 Dec
Effects of different concentrations of sevoflurane and desflurane on subcortical somatosensory evoked responses in anaesthetized, non-stimulated patients.
2001 Jan
Recovery and neurological examination after remifentanil-desflurane or fentanyl-desflurane anaesthesia for carotid artery surgery.
2001 Jan
Model-based administration of inhalation anaesthesia. 2. Exploring the system model.
2001 Jan
Intravenous opioids reduce airway irritation during induction of anaesthesia with desflurane in adults.
2001 Jan
Model-based administration of inhalation anaesthesia. 1. Developing a system model.
2001 Jan
A case report of a fractured healthytooth during use of Guedel oropharyngeal airway.
2001 Jul
Prediction of volatile anaesthetic solubility in blood and priming fluids for extracorporeal circulation.
2001 Mar
Inhalation anaesthetics increase heart rate by decreasing cardiac vagal activity in dogs.
2001 Nov
Carbon monoxide production from desflurane, enflurane, halothane, isoflurane, and sevoflurane with dry soda lime.
2001 Nov
Viscosity and density of common anaesthetic gases: implications for flow measurements.
2001 Oct
Measuring the costs of inhaled anaesthetics.
2001 Oct
Blood solubilities of volatile anesthetics in cardiac patients.
2001 Oct
Dynamic changes in blood solubility of desflurane, isoflurane, and halothane during cardiac surgery.
2001 Oct
[The effect of propofol vs desflurane on recovery from anesthesia with remifentanil in outpatient surgery].
2001 Oct
Goal oriented general anesthesia for Cesarean section in a parturient with a large intracranial epidermoid cyst.
2001 Oct
Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs.
2001 Oct
Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations.
2001 Oct
[Alternatives to nitrous oxide-desflurane].
2001 Oct
200 years of nitrous oxide (laughing gas)--and the end of an era?
2001 Oct
Oxidative stress status during exposure to propofol, sevoflurane and desflurane.
2001 Oct
The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene.
2001 Oct
Prolonged anesthesia with desflurane and fentanyl in dogs during conventional and laparoscopic surgery.
2001 Oct 1
Desflurane, sevoflurane, and isoflurane affect left atrial active and passive mechanical properties and impair left atrial-left ventricular coupling in vivo: analysis using pressure-volume relations.
2001 Sep
Sub-MAC concentrations of desflurane do not inhibit hypoxic pulmonary vasoconstriction in anesthetized piglets.
2001 Sep
The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral position.
2002 Apr
Phantom anaesthetic vapour.
2002 Feb
Effects of desflurane and isoflurane on intestinal tissue oxygen pressure during colorectal surgery.
2002 Feb
Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement.
2002 Feb
Small-dose selective spinal anesthesia for short-duration outpatient laparoscopy: recovery characteristics compared with desflurane anesthesia.
2002 Feb
Anaesthetic agents in paediatric day case surgery: do they affect outcome?
2002 Jan
Model-based administration of inhalation anaesthesia. 3. Validating the system model.
2002 Jan
Fresh gas flow is not the only determinant of volatile agent consumption: a multi-centre study of low-flow anaesthesia.
2002 Jan
Effects of desflurane on jugular bulb gases and pressure in neurosurgical patients.
2002 Jan
The assessment of postural stability after ambulatory anesthesia: a comparison of desflurane with propofol.
2002 Jan
Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.
2002 Jan
Subcellular localization of trifluoroacetylated liver proteins in association with hepatitis following isoflurane.
2002 Mar
The relationship between acceleromyographic train-of-four fade and single twitch depression.
2002 Mar
Selective spinal anesthesia versus desflurane anesthesia in short duration outpatient gynecological laparoscopy: a pharmacoeconomic comparison.
2002 Mar
Fast-track eligibility of geriatric patients undergoing short urologic surgery procedures.
2002 Mar
Name Type Language
DESFLURANE
EP   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
DESFLURANE [INN]
Common Name English
I-653
Code English
DESFLURANE [USAN]
Common Name English
DESFLURANE [VANDF]
Common Name English
ETHANE, 2-(DIFLUOROMETHOXY)-1,1,1,2-TETRAFLUORO-, (+/-)-
Systematic Name English
DESFLURANE [USP MONOGRAPH]
Common Name English
DESFLURANE [ORANGE BOOK]
Common Name English
DESFLURANE [USP-RS]
Common Name English
DESFLURANE [JAN]
Common Name English
(+/-)-2-DIFLUOROMETHYL 1,2,2,2-TETRAFLUOROETHYL ETHER
Common Name English
DESFLURANE [WHO-DD]
Common Name English
SUPRANE
Brand Name English
DESFLURANE [EP MONOGRAPH]
Common Name English
DESFLURANE [MI]
Common Name English
DESFLURANE [MART.]
Common Name English
Classification Tree Code System Code
WHO-ATC N01AB07
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
NCI_THESAURUS C245
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
WHO-VATC QN01AB07
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
LIVERTOX 282
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
NDF-RT N0000175681
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
NDF-RT N0000175975
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
Code System Code Type Description
RXCUI
27340
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY RxNorm
DRUG CENTRAL
811
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
CAS
57041-67-5
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
USP_CATALOG
1171900
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY USP-RS
WIKIPEDIA
DESFLURANE
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
CAS
1351959-69-7
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
ALTERNATIVE
DRUG BANK
DB01189
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
INN
6505
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
IUPHAR
7156
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
HSDB
8058
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
MERCK INDEX
M4190
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY Merck Index
FDA UNII
CRS35BZ94Q
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
ChEMBL
CHEMBL1200733
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
LACTMED
Desflurane
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
CAS
1351959-65-3
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
ALTERNATIVE
PUBCHEM
42113
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
MESH
C053562
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
NCI_THESAURUS
C47472
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY
EVMPD
SUB06993MIG
Created by admin on Fri Jun 25 20:53:27 UTC 2021 , Edited by admin on Fri Jun 25 20:53:27 UTC 2021
PRIMARY