U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C3H2F6O
Molecular Weight 168.0378
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DESFLURANE

SMILES

FC(F)OC(F)C(F)(F)F

InChI

InChIKey=DPYMFVXJLLWWEU-UHFFFAOYSA-N
InChI=1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H

HIDE SMILES / InChI

Molecular Formula C3H2F6O
Molecular Weight 168.0378
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Desflurane is a non-flammable liquid administered via vaporizer as a general anesthetic. It is halogenated exclusively with fluorine and is very resistant to defluorination. For this reason, it is not associated with nephrotoxicity, as is the case with other inhalational anesthetics. Desflurane is indicated for the induction and/or maintenance of anesthesia and adults, and for maintenance of anesthesia in pediatric patients following the induction with other agents.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SUPRANE

Approved Use

Suprane is an inhalation agent indicated for induction and/or maintenance of anesthesia in adults, for maintenance of anesthesia in pediatric patients following induction with agents other than Suprane (desflurane, USP) and intubation.

Launch Date

7.1677438E11
Doses

Doses

DosePopulationAdverse events​
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Other AEs: Airways obstruction, Breath holding...
Other AEs:
Airways obstruction (4%)
Breath holding (3%)
Bronchospasm (1%)
Coughing (26%)
Hiccups (1%)
Laryngospasm (13%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Bronchospasm 1%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Hiccups 1%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Laryngospasm 13%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Coughing 26%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Breath holding 3%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Airways obstruction 4%
0.7 MAC single, respiratory (mean)
Recommended
Dose: 0.7 MAC
Route: respiratory
Route: single
Dose: 0.7 MAC
Sources:
unhealthy, 2-16
n = 300
Health Status: unhealthy
Condition: surgery
Age Group: 2-16
Population Size: 300
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
Drug as victim

Drug as victim

PubMed

PubMed

TitleDatePubMed
Renal responses to low-flow desflurane, sevoflurane, and propofol in patients.
2000 Dec
Comparison of the influence of desflurane nitrous oxide anesthesia to propofol nitrous oxide anesthesia on rocuronium bromide induced neuromuscular block.
2001
Use of remifentanil in combination with desflurane or propofol for ambulatory oral surgery.
2001
Occupational exposure to volatile anaesthetics: epidemiology and approaches to reducing the problem.
2001
Desflurane, compared to halothane, augments phenylephrine-induced contraction in isolated rat aorta smooth muscle.
2001 Apr
Induction of anaesthesia with desflurane and isoflurane in the rabbit.
2001 Apr
A double-blind, randomized comparison of low-dose rocuronium and atracurium in a desflurane anesthetic.
2001 Aug
Influence of sepsis on minimum alveolar concentration of desflurane in a porcine model.
2001 Aug
Effects of desflurane on cerebral autoregulation.
2001 Aug
The ADU vaporizing unit: a new vaporizer.
2001 Aug
The recovery of cognitive function after general anesthesia in elderly patients: a comparison of desflurane and sevoflurane.
2001 Dec
Protective effects of volatile agents against methacholine-induced bronchoconstriction in rats.
2001 Feb
Desflurane or sevoflurane for gynaecological day-case anaesthesia with spontaneous respiration?
2001 Feb
Clinical evaluation of the Mapleson theoretical ideal fresh gas flow sequence at the start of low-flow anaesthesia with isoflurane, sevoflurane and desflurane.
2001 Feb
Smoking status and body size increase carbon monoxide concentrations in the breathing circuit during low-flow anesthesia.
2001 Feb
The use of esmolol as an alternative to remifentanil during desflurane anesthesia for fast-track outpatient gynecologic laparoscopic surgery.
2001 Feb
Effects of different concentrations of sevoflurane and desflurane on subcortical somatosensory evoked responses in anaesthetized, non-stimulated patients.
2001 Jan
Cerebral hemodynamic response to the introduction of desflurane: a comparison with sevoflurane.
2001 Jan
Fast-track office-based anesthesia: a comparison of propofol versus desflurane with antiemetic prophylaxis in spontaneously breathing patients.
2001 Jan
Shannon entropy applied to the measurement of the electroencephalographic effects of desflurane.
2001 Jul
Pharmacodynamic interaction of nitrous oxide with sevoflurane, desflurane, isoflurane and enflurane in surgical patients: measurements by effects on EEG median power frequency.
2001 Jul
The carbon dioxide absorption capacity of Amsorb is half that of soda lime.
2001 Jul
Lack of degradation of sevoflurane by a new carbon dioxide absorbent in humans.
2001 Jun
Desflurane reduces the effective therapeutic infusion rate (ETI) of cisatracurium more than isoflurane, sevoflurane, or propofol.
2001 Jun
[The effect of anesthetic technique on recovery from neuromuscular blockade with cisatracurium].
2001 Mar
Recovery profile and side effects of remifentanil-based anaesthesia with desflurane or propofol for laparoscopic cholecystectomy.
2001 Mar
[Droperidol and dimenhydrinate alone or in combination for prevention of postoperative nausea and vomiting].
2001 May
The midlatency auditory evoked potentials predict responsiveness to verbal commands in patients emerging from anesthesia with xenon, isoflurane, and sevoflurane but not with nitrous oxide.
2001 May
Composition of CO(2) absorbents.
2001 May
Measuring the costs of inhaled anaesthetics.
2001 Oct
Dynamic changes in blood solubility of desflurane, isoflurane, and halothane during cardiac surgery.
2001 Oct
Goal oriented general anesthesia for Cesarean section in a parturient with a large intracranial epidermoid cyst.
2001 Oct
Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs.
2001 Oct
Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations.
2001 Oct
[Alternatives to nitrous oxide-desflurane].
2001 Oct
200 years of nitrous oxide (laughing gas)--and the end of an era?
2001 Oct
The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene.
2001 Oct
Prolonged anesthesia with desflurane and fentanyl in dogs during conventional and laparoscopic surgery.
2001 Oct 1
Sub-MAC concentrations of desflurane do not inhibit hypoxic pulmonary vasoconstriction in anesthetized piglets.
2001 Sep
The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral position.
2002 Apr
Effects of desflurane and isoflurane on intestinal tissue oxygen pressure during colorectal surgery.
2002 Feb
The assessment of postural stability after ambulatory anesthesia: a comparison of desflurane with propofol.
2002 Jan
Substance Class Chemical
Created
by admin
on Sat Dec 16 15:52:42 UTC 2023
Edited
by admin
on Sat Dec 16 15:52:42 UTC 2023
Record UNII
CRS35BZ94Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DESFLURANE
EP   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
desflurane [INN]
Common Name English
I-653
Code English
DESFLURANE [USAN]
Common Name English
DESFLURANE [VANDF]
Common Name English
Desflurane [WHO-DD]
Common Name English
ETHANE, 2-(DIFLUOROMETHOXY)-1,1,1,2-TETRAFLUORO-, (±)-
Systematic Name English
DESFLURANE [USP MONOGRAPH]
Common Name English
DESFLURANE [ORANGE BOOK]
Common Name English
DESFLURANE [USP-RS]
Common Name English
DESFLURANE [JAN]
Common Name English
(±)-2-DIFLUOROMETHYL 1,2,2,2-TETRAFLUOROETHYL ETHER
Common Name English
SUPRANE
Brand Name English
DESFLURANE [EP MONOGRAPH]
Common Name English
DESFLURANE [MI]
Common Name English
DESFLURANE [MART.]
Common Name English
Classification Tree Code System Code
WHO-ATC N01AB07
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
NCI_THESAURUS C245
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
WHO-VATC QN01AB07
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
LIVERTOX NBK548717
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
NDF-RT N0000175681
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
NDF-RT N0000175975
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
Code System Code Type Description
RXCUI
27340
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY RxNorm
DRUG CENTRAL
811
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
CAS
57041-67-5
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
WIKIPEDIA
DESFLURANE
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
DRUG BANK
DB01189
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
INN
6505
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
SMS_ID
100000083168
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
IUPHAR
7156
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
DAILYMED
CRS35BZ94Q
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
EPA CompTox
DTXSID80866606
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
USAN
BB-12
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
HSDB
8058
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
MERCK INDEX
m4190
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY Merck Index
FDA UNII
CRS35BZ94Q
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
ChEMBL
CHEMBL1200733
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
LACTMED
Desflurane
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
PUBCHEM
42113
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
CHEBI
4445
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
MESH
C053562
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
NCI_THESAURUS
C47472
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
EVMPD
SUB06993MIG
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
RS_ITEM_NUM
1171900
Created by admin on Sat Dec 16 15:52:44 UTC 2023 , Edited by admin on Sat Dec 16 15:52:44 UTC 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
TARGET -> AGONIST
TARGET -> INHIBITOR
ENANTIOMER -> RACEMATE
TARGET -> INHIBITOR
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CHROMATOGRAPHIC PURITY (GC)
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IMPURITY -> PARENT
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IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
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IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
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IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
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IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
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IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
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IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
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Related Record Type Details
ACTIVE MOIETY