Details
Stereochemistry | RACEMIC |
Molecular Formula | C3H2F6O |
Molecular Weight | 168.0378 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)OC(F)C(F)(F)F
InChI
InChIKey=DPYMFVXJLLWWEU-UHFFFAOYSA-N
InChI=1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H
Molecular Formula | C3H2F6O |
Molecular Weight | 168.0378 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Desflurane is a non-flammable liquid administered via vaporizer as a general anesthetic. It is halogenated exclusively with fluorine and is very resistant to defluorination. For this reason, it is not associated with nephrotoxicity, as is the case with other inhalational anesthetics. Desflurane is indicated for the induction and/or maintenance of anesthesia and adults, and for maintenance of anesthesia in pediatric patients following the induction with other agents.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | SUPRANE Approved UseSuprane is an inhalation agent indicated for induction and/or maintenance of anesthesia in adults, for maintenance of anesthesia in pediatric patients following induction with agents other than Suprane (desflurane, USP) and intubation. Launch Date7.1677438E11 |
Doses
Dose | Population | Adverse events |
---|---|---|
0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: |
unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: |
Other AEs: Airways obstruction, Breath holding... Other AEs: Airways obstruction (4%) Sources: Breath holding (3%) Bronchospasm (1%) Coughing (26%) Hiccups (1%) Laryngospasm (13%) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Bronchospasm | 1% | 0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: |
unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: |
Hiccups | 1% | 0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: |
unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: |
Laryngospasm | 13% | 0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: |
unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: |
Coughing | 26% | 0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: |
unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: |
Breath holding | 3% | 0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: |
unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: |
Airways obstruction | 4% | 0.7 MAC single, respiratory (mean) Recommended Dose: 0.7 MAC Route: respiratory Route: single Dose: 0.7 MAC Sources: |
unhealthy, 2-16 n = 300 Health Status: unhealthy Condition: surgery Age Group: 2-16 Population Size: 300 Sources: |
PubMed
Title | Date | PubMed |
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Comparison of the influence of desflurane nitrous oxide anesthesia to propofol nitrous oxide anesthesia on rocuronium bromide induced neuromuscular block. | 2001 |
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A survey on anesthesia for thoracoscopic sympathetic surgery in treatment of hyperhidrosis palmaris in Taiwan. | 2001 |
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Simultaneous determination of fluorinated inhalation anesthetics in blood by gas chromatography-mass spectrometry combined with a headspace autosampler. | 2001 Aug 15 |
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Prevention of PONV with dexamethasone in female patients undergoing desflurane anesthesia for thyroidectomy. | 2001 Dec |
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EEG complexity as a measure of depth of anesthesia for patients. | 2001 Dec |
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The recovery of cognitive function after general anesthesia in elderly patients: a comparison of desflurane and sevoflurane. | 2001 Dec |
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The effects of increasing concentrations of isoflurane and desflurane on pulmonary perfusion and systemic oxygenation during one-lung ventilation in pigs. | 2001 Dec |
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Integrated analysis of protein and glucose metabolism during surgery: effects of anesthesia. | 2001 Dec |
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Effects of different concentrations of sevoflurane and desflurane on subcortical somatosensory evoked responses in anaesthetized, non-stimulated patients. | 2001 Jan |
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Recovery and neurological examination after remifentanil-desflurane or fentanyl-desflurane anaesthesia for carotid artery surgery. | 2001 Jan |
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Model-based administration of inhalation anaesthesia. 2. Exploring the system model. | 2001 Jan |
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Intravenous opioids reduce airway irritation during induction of anaesthesia with desflurane in adults. | 2001 Jan |
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A case report of a fractured healthytooth during use of Guedel oropharyngeal airway. | 2001 Jul |
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Shannon entropy applied to the measurement of the electroencephalographic effects of desflurane. | 2001 Jul |
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A comparison of the transient hyperemic response test and the static autoregulation test to assess graded impairment in cerebral autoregulation during propofol, desflurane, and nitrous oxide anesthesia. | 2001 Jul |
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Fast-tracking after outpatient laparoscopy: reasons for failure after propofol, sevoflurane, and desflurane anesthesia. | 2001 Jul |
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The future of inhalation anaesthesia. Die Zukunft der Inhalationsanasthesie. | 2001 Jun |
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The effect of sevoflurane and desflurane on upper airway reactivity. | 2001 Jun |
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Lack of degradation of sevoflurane by a new carbon dioxide absorbent in humans. | 2001 Jun |
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Prediction of volatile anaesthetic solubility in blood and priming fluids for extracorporeal circulation. | 2001 Mar |
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Mathematical modeling of carbon monoxide exposures from anesthetic breakdown: effect of subject size, hematocrit, fraction of inspired oxygen, and quantity of carbon monoxide. | 2001 Mar |
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Physical factors affecting the production of carbon monoxide from anesthetic breakdown. | 2001 Mar |
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[Droperidol and dimenhydrinate alone or in combination for prevention of postoperative nausea and vomiting]. | 2001 May |
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Inhalation anaesthetics increase heart rate by decreasing cardiac vagal activity in dogs. | 2001 Nov |
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Viscosity and density of common anaesthetic gases: implications for flow measurements. | 2001 Oct |
|
Measuring the costs of inhaled anaesthetics. | 2001 Oct |
|
Blood solubilities of volatile anesthetics in cardiac patients. | 2001 Oct |
|
Dynamic changes in blood solubility of desflurane, isoflurane, and halothane during cardiac surgery. | 2001 Oct |
|
Goal oriented general anesthesia for Cesarean section in a parturient with a large intracranial epidermoid cyst. | 2001 Oct |
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Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs. | 2001 Oct |
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Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations. | 2001 Oct |
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[Alternatives to nitrous oxide-desflurane]. | 2001 Oct |
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200 years of nitrous oxide (laughing gas)--and the end of an era? | 2001 Oct |
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Prolonged anesthesia with desflurane and fentanyl in dogs during conventional and laparoscopic surgery. | 2001 Oct 1 |
|
Desflurane, sevoflurane, and isoflurane affect left atrial active and passive mechanical properties and impair left atrial-left ventricular coupling in vivo: analysis using pressure-volume relations. | 2001 Sep |
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The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral position. | 2002 Apr |
|
Phantom anaesthetic vapour. | 2002 Feb |
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Effects of desflurane and isoflurane on intestinal tissue oxygen pressure during colorectal surgery. | 2002 Feb |
|
Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement. | 2002 Feb |
|
Small-dose selective spinal anesthesia for short-duration outpatient laparoscopy: recovery characteristics compared with desflurane anesthesia. | 2002 Feb |
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Anaesthetic agents in paediatric day case surgery: do they affect outcome? | 2002 Jan |
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Model-based administration of inhalation anaesthesia. 3. Validating the system model. | 2002 Jan |
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Fresh gas flow is not the only determinant of volatile agent consumption: a multi-centre study of low-flow anaesthesia. | 2002 Jan |
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Effects of desflurane on jugular bulb gases and pressure in neurosurgical patients. | 2002 Jan |
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The assessment of postural stability after ambulatory anesthesia: a comparison of desflurane with propofol. | 2002 Jan |
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Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo. | 2002 Jan |
|
Subcellular localization of trifluoroacetylated liver proteins in association with hepatitis following isoflurane. | 2002 Mar |
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The relationship between acceleromyographic train-of-four fade and single twitch depression. | 2002 Mar |
|
Selective spinal anesthesia versus desflurane anesthesia in short duration outpatient gynecological laparoscopy: a pharmacoeconomic comparison. | 2002 Mar |
|
Fast-track eligibility of geriatric patients undergoing short urologic surgery procedures. | 2002 Mar |
Substance Class |
Chemical
Created
by
admin
on
Edited
Thu Jul 06 21:24:56 UTC 2023
by
admin
on
Thu Jul 06 21:24:56 UTC 2023
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Record UNII |
CRS35BZ94Q
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Record Status |
Validated (UNII)
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Record Version |
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WHO-ATC |
N01AB07
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NCI_THESAURUS |
C245
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WHO-VATC |
QN01AB07
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LIVERTOX |
NBK548717
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NDF-RT |
N0000175681
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NDF-RT |
N0000175975
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DESFLURANE
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CHEMBL1200733
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C47472
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SUB06993MIG
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1171900
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Related Record | Type | Details | ||
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ENANTIOMER -> RACEMATE |
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TARGET -> AGONIST |
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TARGET -> INHIBITOR |
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ENANTIOMER -> RACEMATE |
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TARGET -> INHIBITOR |
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Related Record | Type | Details | ||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
USP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (GC)
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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