U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 7 of 7 results

Status:
US Approved Rx (2024)
First approved in 1992

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Bisoprolol is a cardioselective beta1-adrenergic blocking agent. It lower the heart rate and blood pressure and may be used to reduce workload on the heart and hence oxygen demands. This results in a reduction of heart rate, cardiac output, systolic ...
Status:
US Approved Rx (2015)
First approved in 1987

Class (Stereo):
CHEMICAL (RACEMIC)



Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds...
Status:
US Approved Rx (2013)
First approved in 1959

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

CAPOZIDE (captopril and hydrochlorothiazide tablets, USP) for oral administration combines two antihypertensive agents: captopril and hydrochlorothiazide. The mechanism of action of captopril has not yet been fully elucidated. Captopril prevents the ...
Status:
US Approved Rx (2001)
First approved in 1953

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Hydralazine is a direct-acting vasodilator that is used as an antihypertensive agent. Hydralazine works by relaxing blood vessels (arterioles more than venules) and increasing the supply of blood and oxygen to the heart while reducing its workload. I...
Status:
US Approved Rx (2001)
First approved in 1985

Class (Stereo):
CHEMICAL (ABSOLUTE)



Enalapril (marketed as Vasotec in the US, Enaladex and Renitec in some other countries) is an angiotensin-converting-enzyme (ACE) inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Enalapri...
Status:
US Approved Rx (1985)
First approved in 1962

Class (Stereo):
CHEMICAL (ABSOLUTE)



Methyldopate hydrochloride [levo-3-(3,4-dihydroxyphenyl)-2-methylalanine, ethyl ester hydrochloride] is the ethyl ester of methyldopa, supplied as the hydrochloride salt with a molecular weight of 275.73. Methyldopate hydrochloride is more soluble an...
Status:
US Approved Rx (2018)
First marketed in 1921

Class (Stereo):
CHEMICAL (ACHIRAL)



Pentaerythritol tetranitrate is an organic nitrate that has been used for the treatment of angina pectoris. Upon administration, the drug undergoes exstensive metabolism to NO which causes vasodilation and the relaxation of smooth muscle cells. The c...