U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 10 of 33 results

Status:
US Approved Rx (2018)
First approved in 2011

Class (Stereo):
CHEMICAL (ACHIRAL)



Clobazam belongs to the 1,5-benzodiazepine class of drugs with antiepileptic properties. It has been used to treat anxiety and epilepsy since 1970s. In the US clobazam was approved for marketing in October of 2011 for the adjunctive treatment of seiz...
Status:
US Approved Rx (2015)
First approved in 1986

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. Animal studies have suggested antianxiety activity and the absence of abuse potential. Behavioural, electrophysiological and receptor binding experiments gradua...
Status:
US Approved Rx (2010)
First approved in 1981

Class (Stereo):
CHEMICAL (ACHIRAL)



Alprazolam, a benzodiazepine, is used to treat panic disorder and anxiety disorder. Unlike chlordiazepoxide, clorazepate, and prazepam, alprazolam has a shorter half-life and metabolites with minimal activity. Alprazolam may have significant drug int...
Status:
US Approved Rx (1980)
First approved in 1977

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Lorazepam (brand name Ativan) is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life ...
Status:
US Approved Rx (1988)
First approved in 1965

Class (Stereo):
CHEMICAL (RACEMIC)



Oxazepam is the first of a chemical series of compounds, the 3-hydroxybenzodiazepinones. A therapeutic agent providing versatility and flexibility in control of common emotional disturbances, this product exerts prompt action in a wide variety of dis...
Status:
US Approved Rx (1988)
First approved in 1963

Class (Stereo):
CHEMICAL (ACHIRAL)



Diazepam is a benzodiazepine first discovered at Hoffman-La Roche in the late 1950s. Diazepam was approved by FDA for the treatment of anxiety disorders as well as for such conditions as skeletal muscle spasm, alcohol withdrawal syndrom and convulsion...
Status:
US Approved Rx (2022)
First approved in 1960

Class (Stereo):
CHEMICAL (ACHIRAL)



Chlordiazepoxide (trade name Librium) is a sedative and hypnotic medication of the benzodiazepine class. Chlordiazepoxide is indicated for the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of...
Status:
US Approved Rx (2008)
First approved in 1956

Class (Stereo):
CHEMICAL (RACEMIC)



Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic ...
Status:
US Approved Rx (2009)
First approved in 1955

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Meprobamate is a carbamate derivative used as an anxiolytic drug. Meprobamate enhances GABA-A currents, and at higher concentration, exhibits a separate channel-blocking effect that limits the magnitude of GABA(A) receptor potentiation. It is also ...
Status:
US Previously Marketed
First approved in 1981

Class (Stereo):
CHEMICAL (ACHIRAL)



Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Halazepam is used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Halazepam (Paxipam)...