U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Showing 1 - 10 of 27 results

Status:
US Approved Rx (2008)
First approved in 2008

Class (Stereo):
CHEMICAL (ACHIRAL)



Eltrombopag is a thrombopoietin (TPO) nonpeptide mimetic administered orally that activates the TPO receptor by binding to the transmembrane domain and initiates signaling cascades that induce proliferation and differentiation of megakaryocytes from ...
Status:
US Approved Rx (2023)
First approved in 1986

Class (Stereo):
CHEMICAL (ACHIRAL)



Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin. Tranexamic acid is a competitive inhibitor of plasminogen activation, and at much higher concentrations, a noncompetitive inhibitor of plasmi...
Status:
US Previously Marketed
First approved in 1940

Class (Stereo):
CHEMICAL (ACHIRAL)



Menadione, a drug belong to class of Vitamin K, is prescribed for the treatment of hemorrhage, vitamin K deficiency, moderate to severe forms of hypoprothrombinaemia in adults and children. Menadione is a synthetic form of vitamin K, a lipid-soluble ...
Status:
US Previously Marketed
First marketed in 1937

Class (Stereo):
CHEMICAL (ACHIRAL)



Adrenalone is a keton form of the natural substrate epinephrine. Adrenalone is evidently formed in vivo by hydrolytic cleavage of the diester by esterases. It is an adrenergic receptor agonist. Adrenalone inhibits the norepinephrine synthesis and dop...
Status:
Possibly Marketed Outside US
First approved in 2019

Class (Stereo):
CHEMICAL (ACHIRAL)

Aminomethylbenzoic acid (or p-aminomethylbenzoic acid, or PAMBA) an antifibrinolytic agent. This drug has been used for the treatment of internal hemorrhage during chronic disseminated intravascular coagulation.
Status:
Possibly Marketed Outside US
First approved in 2018

Class (Stereo):
CHEMICAL (RACEMIC)



Carbazochrome Sulfonic Acid is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. It is hoped that this...
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Tetragalacturonic acid hydroxymethylester belongs to local hemostatics. It is an antihemorrhagic agent.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Camostat mesilate (FOY-305) is a synthetic f low-molecular weight protease inhibitor. It is able to inhibit trypsin, prostasin, matriptase and plasma kallikrein. In addition camostat attenuates airway epithelial sodium channel function and enhances m...
mixture
Status:
US Approved Rx (2005)
First approved in 1979

Class:
MIXTURE

mixture
Status:
US Approved Rx (2024)
First approved in 1940

Class:
MIXTURE



Phylloquinone is often called vitamin K1 or phytonadione. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumat...