Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H22N4O5 |
Molecular Weight | 398.4133 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)C(=O)COC(=O)Cc1ccc(cc1)OC(=O)c2ccc(cc2)NC(=N)N
InChI
InChIKey=XASIMHXSUQUHLV-UHFFFAOYSA-N
InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23)
Molecular Formula | C20H22N4O5 |
Molecular Weight | 398.4133 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.e-search.ne.jp/~jpr/PDF/ONO01.PDFCurator's Comment:: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19190233 | https://www.ncbi.nlm.nih.gov/pubmed/3040018
Sources: http://www.e-search.ne.jp/~jpr/PDF/ONO01.PDF
Curator's Comment:: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19190233 | https://www.ncbi.nlm.nih.gov/pubmed/3040018
Camostat mesilate (FOY-305) is a synthetic f low-molecular weight protease inhibitor. It is able to inhibit trypsin, prostasin, matriptase and plasma kallikrein. In addition camostat attenuates airway epithelial sodium channel function and enhances mucociliary clearance. Camostat mesilate tablets (FOIPAN®) are approved in Japan and used for the treatment of remission of acute symptoms of chronic pancreatitis and postoperative reflux esophagitis.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2455235
Curator's Comment:: Camostat mesilate (FOY-305) is CNS active in animals. No human data available.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2095204 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19190233 |
1.0 nM [Ki] | ||
Target ID: CHEMBL3018 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19190233 |
4.0 nM [Ki] | ||
Target ID: CHEMBL5610 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19190233 |
0.576 µM [Ki] | ||
Target ID: CHEMBL2107836 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19190233 |
50.0 nM [IC50] | ||
Target ID: CHEMBL2000 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3040018 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Primary | FOIPAN Approved UseINDICATIONS
1. Remission of acute symptoms of chronic pancreatitis
2. Postoperative reflux esophagitis Launch Date7.729344E11 |
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Primary | FOIPAN Approved UseINDICATIONS
1. Remission of acute symptoms of chronic pancreatitis
2. Postoperative reflux esophagitis Launch Date7.729344E11 |
|||
Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
New orally active serine protease inhibitors. | 1995 Jul 7 |
|
Different effects of oral administration of synthetic trypsin inhibitor on the pancreas between cholecystokinin-A receptor gene knockout mice and wild type mice. | 2002 Jul |
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Circulating ethanol does not stimulate pancreatic secretion in conscious rats. | 2003 Nov |
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[Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes]. | 2006 Jul |
|
Strategies of development of antiviral agents directed against influenza virus replication. | 2007 |
|
[Fibrosis markers in heavy alcohol drinkers]. | 2007 Aug |
|
Matrix metalloproteinase gene delivery for liver fibrosis. | 2008 Feb |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.e-search.ne.jp/~jpr/PDF/ONO01.PDF
1. Remission of acute symptoms of chronic pancreatitis. The usual dosage for oral use is 600 mg of camostat mesilate daily in three divided doses. The dosage may be adjusted according to the patient’s symptoms.
2. Postoperative reflux esophagitis. The usual dosage for oral use is 300 mg of camostat mesilate
daily in three divided doses after each meal.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11375959
Camostat mesilate (500 uM) inhibited generation of TGF-beta by suppressing plasmin activity and reduced the activity of TGF-beta, which blocked in vitro activation of the rat hepatic stellate cells.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 00:22:26 UTC 2021
by
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on
Sat Jun 26 00:22:26 UTC 2021
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Record UNII |
0FD207WKDU
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Record Status |
Validated (UNII)
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Record Version |
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Official Name | English | ||
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Common Name | English | ||
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Classification Tree | Code System | Code | ||
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WHO-VATC |
QB02AB04
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WHO-ATC |
B02AB04
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NCI_THESAURUS |
C783
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FDA ORPHAN DRUG |
338211
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C034532
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M3000
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59721-28-7
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471
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59721-28-7
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DB13729
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CHEMBL590799
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2536
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C73213
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0FD207WKDU
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SUB06066MIG
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5068
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CAMOSTAT
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6432
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Related Record | Type | Details | ||
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TARGET ORGANISM->INHIBITOR |
nother in vitro study showed that Camostat reduces significantly the infection of Calu-3 lung cells by SARS-CoV-2, the virus responsible for COVID-19.[9]
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |