Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 11:55:35 GMT 2023
by
admin
on
Sat Dec 16 11:55:35 GMT 2023
|
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
XJ447D496R
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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O15393
Created by
admin on Sat Dec 16 11:55:35 GMT 2023 , Edited by admin on Sat Dec 16 11:55:35 GMT 2023
|
PRIMARY | |||
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252212-87-6
Created by
admin on Sat Dec 16 11:55:35 GMT 2023 , Edited by admin on Sat Dec 16 11:55:35 GMT 2023
|
GENERIC (FAMILY) | |||
|
XJ447D496R
Created by
admin on Sat Dec 16 11:55:35 GMT 2023 , Edited by admin on Sat Dec 16 11:55:35 GMT 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_113 | 1_126 |
| 1_120 | 1_139 |
| 1_133 | 1_148 |
| 1_172 | 1_231 |
| 1_185 | 1_241 |
| 1_244 | 2_110 |
| 2_26 | 2_42 |
| 2_155 | 2_171 |
| 2_182 | 2_210 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_213 |
| N | 1_249 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
May block Sars-CoV-2 infection inhibiting spike protein infectivity.
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
Activation of TMPRSS2 plays an important role in viral respiratory diseases such as influenza A and Middle East Respiratory Syndrome (MERS). Inhibition of receptor activation and viral entry by bromhexine may be effective in preventing or treating various respiratory illnesses, including COVID-19.5 In vitro studies have suggested the action of ambroxol (a metabolite of bromhexine) on the angiogensin-converting enzyme receptor 2 (ACE2), prevents entry of the viral envelope-anchored spike glycoprotein of SARS-Cov-2 into alveolar cells or increases the secretion of surfactant, preventing viral entry.
IC50
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|