U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 17:32:30 UTC 2023
Edited
by admin
on Thu Jul 06 17:32:30 UTC 2023
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
XJ447D496R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRANSMEMBRANE PROTEASE SERINE 2
Common Name English
TMPRSS2
Common Name English
SERINE PROTEASE 10
Common Name English
PRSS10
Common Name English
Code System Code Type Description
UNIPROT
O15393
Created by admin on Thu Jul 06 17:32:30 UTC 2023 , Edited by admin on Thu Jul 06 17:32:30 UTC 2023
PRIMARY
CAS
252212-87-6
Created by admin on Thu Jul 06 17:32:30 UTC 2023 , Edited by admin on Thu Jul 06 17:32:30 UTC 2023
GENERIC (FAMILY)
FDA UNII
XJ447D496R
Created by admin on Thu Jul 06 17:32:30 UTC 2023 , Edited by admin on Thu Jul 06 17:32:30 UTC 2023
PRIMARY
From To
1_113 1_126
1_120 1_139
1_133 1_148
1_172 1_231
1_185 1_241
1_244 2_110
2_26 2_42
2_155 2_171
2_182 2_210
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_213
N 1_249
Related Record Type Details
INHIBITOR -> TARGET
Activation of TMPRSS2 plays an important role in viral respiratory diseases such as influenza A and Middle East Respiratory Syndrome (MERS). Inhibition of receptor activation and viral entry by bromhexine may be effective in preventing or treating various respiratory illnesses, including COVID-19.5 In vitro studies have suggested the action of ambroxol (a metabolite of bromhexine) on the angiogensin-converting enzyme receptor 2 (ACE2), prevents entry of the viral envelope-anchored spike glycoprotein of SARS-Cov-2 into alveolar cells or increases the secretion of surfactant, preventing viral entry.
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL