Search results for "Pharmacologic Substance[C1909]|Protective Agent[C26170]|Uricosuric Agent" in comments (approximate match)
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Febuxostat (ULORIC) is a novel, xanthine oxidase/dehydrogenase (XO/XDH) inhibitor being developed by Teijin, TAP Pharmaceuticals, and Ipsen for the treatment of gout. The currently available XO inhibitor, allopurinol, has been associated with serious...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Allopurinol is a xanthine oxidase inhibitor used to decrease high blood uric acid levels. Allopurinol is specifically used to prevent gout, prevent specific types of kidney stones, and for the high uric acid levels that can occur with chemotherapy. A...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Probenecid is the prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tub...
Seclazone was developed as a non-steroidal anti-inflammatory agent. This compound also possesses analgesic and antipyretic properties. Information about the current use of this compound is not available.
Class (Stereo):
CHEMICAL (ACHIRAL)
Verinurad (RDEA3170) is a selective uric acid reabsorption inhibitor in clinical development for the treatment of gout and asymptomatic hyperuricemia. Verinurad specifically inhibits URAT1 with a potency of 25 nM. High affinity inhibition of uric aci...
IRTEMAZOLE is a uricosuric agent exhibiting a rapid uricosuric effect in normouricemic as well as in hyperuricemic persons.
Ciapilome is pyrimidinone derivative patented by German pharmaceutical company Byk Gulden Lomberg Chemical Factory GmbH as xanthine oxidase inhibitor for the treatment of gout, arrhythmia, and heart insufficiencies. Ciapilome causes a pronounced decr...
Neocinchophen is an analgesic and uricosuric. Cinchophen and neocinchophen (introduced by Chemische Fabrik auf Aktien as Atophan and Novatophan) were being advertised as superior substitutes for salicylates in the treatment of rheumatic fever. Chemic...
Nicoxamat (nicotinohydroxamic acid) is a uricosuric drug that increased urinary excretion of urea and depressed urease activity in the stomach and the colon. Patients receiving nicoxamat showed significant improvement in blood ammonia levels as compa...
Halofenate (MK-185) was invented as a hypolipidemic and hypouricemic agent. It was shown that halofenate lower serum triglycerides and uric acid in patients with a variety of hyperlipidemias. Treatment of dyslipidemic type 2 diabetic patients also sh...