NICOXAMAT

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H6N2O2
Molecular Weight	138.124
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ONC(=O)C1=CC=CN=C1

InChI

InChIKey=IYCHDNQCHLMLJZ-UHFFFAOYSA-N

InChI=1S/C6H6N2O2/c9-6(8-10)5-2-1-3-7-4-5/h1-4,10H,(H,8,9)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2932777 | https://www.ncbi.nlm.nih.gov/pubmed/6217100

Nicoxamat (nicotinohydroxamic acid) is a uricosuric drug that increased urinary excretion of urea and depressed urease activity in the stomach and the colon. Patients receiving nicoxamat showed significant improvement in blood ammonia levels as compared to patients receiving neomycin. In a double-blind clinical trial, 24 patients with the advanced chronic liver disease received 1.2 g of the drug daily. Nicoxamat induced some side effects, such as mild diarrhea, constipation, and anorexia.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial urease 4 Target ID: CHEMBL2364683 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2932777	Inhibitor 8297

PubMed

Title	Date	PubMed
Synthesis, characterisation and speciation studies of heterobimetallic pyridinehydroxamate-bridged Pt(II)/M(II) complexes (M = Cu, Ni, Zn). Crystal structure of a novel heterobimetallic 3-pyridinehydroxamate-bridged Pt(II)/Cu(II) wave-like coordination polymer.	2005 Jun 7	15909049
Ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis, characterisation and in vitro pharmacological evaluation.	2008 May	18183430

Sample Use Guides

In Vivo Use Guide

In a double-blind clinical trial 24 patients with advanced chronic liver disease received 1.2 g of Nicoxamat (nicotinohydroxamic acid) daily. The drugs used in this study were uncoated white tablets each of which contained 200 mg of nicotinohydroxamic acid.

Route of Administration: Oral

Name

Type

Language

NICOXAMAT

Official Name

English

NSC-13997

Code

English

nicoxamat [INN]

Common Name

English

NICOXAMAT [JAN]

Common Name

English

NICOTINOHYDROXAMIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C921