Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H6N2O2 |
Molecular Weight | 138.124 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
ONC(=O)C1=CC=CN=C1
InChI
InChIKey=IYCHDNQCHLMLJZ-UHFFFAOYSA-N
InChI=1S/C6H6N2O2/c9-6(8-10)5-2-1-3-7-4-5/h1-4,10H,(H,8,9)
Nicoxamat (nicotinohydroxamic acid) is a uricosuric drug that increased urinary excretion of urea and depressed urease activity in the stomach and the colon. Patients receiving nicoxamat showed significant improvement in blood ammonia levels as compared to patients receiving neomycin. In a double-blind clinical trial, 24 patients with the advanced chronic liver disease received 1.2 g of the drug daily. Nicoxamat induced some side effects, such as mild diarrhea, constipation, and anorexia.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2364683 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2932777 |
PubMed
Title | Date | PubMed |
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Synthesis, characterisation and speciation studies of heterobimetallic pyridinehydroxamate-bridged Pt(II)/M(II) complexes (M = Cu, Ni, Zn). Crystal structure of a novel heterobimetallic 3-pyridinehydroxamate-bridged Pt(II)/Cu(II) wave-like coordination polymer. | 2005 Jun 7 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6217100
In a double-blind clinical trial 24 patients with advanced chronic liver disease
received 1.2 g of Nicoxamat (nicotinohydroxamic acid) daily. The drugs used in this study were uncoated white
tablets each of which contained 200 mg of nicotinohydroxamic acid.
Route of Administration:
Oral
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NCI_THESAURUS |
C921
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ACTIVE MOIETY