U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Showing 1 - 10 of 78 results

Status:
US Approved Rx (2023)
First approved in 2018

Class (Stereo):
CHEMICAL (ABSOLUTE)

Lotilaner is a member of the isoxazoline family, a novel class of parasiticides that targets the nerve receptors of ticks and fleas. This veterinary medicinal product provides immediate and persistent killing activity for 1 month for fleas (Ctenoceph...
Status:
US Approved Rx (2006)
First approved in 2000

Class (Stereo):
CHEMICAL (ACHIRAL)



Meloxicam (brand name Mobic) is an nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Mobic is indicated for the relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis, and has been available i...
Status:
US Approved Rx (2025)
First approved in 1998

Class (Stereo):
CHEMICAL (ACHIRAL)



Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT1 receptor subtype. It was discovered by Boehringer Ingelheim and launched in 1999 as Micardis. It has the highest affinity for the AT1 receptor among commerciall...
Status:
US Approved Rx (2018)
First approved in 1996

Class (Stereo):
CHEMICAL (ABSOLUTE)



Cabergoline is a long-acting dopamine receptor agonist with a high affinity for D2 receptors. Results of in vitro studies demonstrate that cabergoline exerts a direct inhibitory effect on the secretion of prolactin by rat pituitary lactotrophs. It is...
Status:
US Approved Rx (2023)
First approved in 1995

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Sevoflurane is a general anesthetic that is FDA approved for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery. Sevoflurane induces a reduction in junctional conductance by decrea...
Status:
US Approved Rx (2003)
First approved in 1993

Class (Stereo):
CHEMICAL (ACHIRAL)



Torasemide is a pyridine-sulfonylurea type loop diuretic mainly used for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Also for the treatment of hypertension alone or in combination with other ant...
Status:
US Approved Rx (2016)
First approved in 1992

Class (Stereo):
CHEMICAL (MIXED)



SPORANOX is the brand name for itraconazole, an azole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs), each possessing three chiral centers. In vitro studies have demonstrated that itraconazo...
Status:
US Approved Rx (2007)
First approved in 1992

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Terbinafine (brand name Lamisil, Terbisil, Terboderm and others) is an antifungal medication used to treat ringworm and fungal nail infections. Terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the...
Status:
US Approved Rx (2020)
First approved in 1989

Class (Stereo):
CHEMICAL (ACHIRAL)



Clomipramine is an antidepressant drug which was approved by FDA for the treatment of Obsessive-Compulsive Disorder. The exact mechanism of its action is unknown, however it is supposed that it may exert its effect by inhibiting serotonin reuptake.
Status:
US Approved Rx (2013)
First approved in 1987

Class (Stereo):
CHEMICAL (RACEMIC)



Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite d...