LOTILANER

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H14Cl3F6N3O3S
Molecular Weight	596.758
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(Cl)=C(Cl)C(Cl)=C3)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

InChI

InChIKey=HDKWFBCPLKNOCK-SFHVURJKSA-N

InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H14Cl3F6N3O3S
Molecular Weight	596.758
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.credelio.com/about-credelio | http://ec.europa.eu/health/documents/community-register/2018/20180709141258/anx_141258_en.pdf | https://www.vetstream.com/treat/canis/generics/lotilaner

Lotilaner is a member of the isoxazoline family, a novel class of parasiticides that targets the nerve receptors of ticks and fleas. This veterinary medicinal product provides immediate and persistent killing activity for 1 month for fleas (Ctenocephalides felis and C. canis) and ticks (Rhipicephalus sanguineus, Ixodes ricinus, I. hexagonus and Dermacentor reticulatus). The veterinary medicinal product can be used as part of a treatment strategy for the control of flea allergy dermatitis. During clinical testing, no interactions between Lotilaner chewable tablets and routinely used veterinary medicinal products were observed.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

20 to 43 mg lotilaner/kg bodyweight

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:55:29 UTC 2023` Edited by `admin` on `Sat Dec 16 16:55:29 UTC 2023`
Record UNII	HEH4938D7K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOTILANER

Official Name

English

LOTILANER [GREEN BOOK]

Common Name

English

LOTILANER (EMA EPAR: VETERINARY)

Common Name

English

lotilaner [INN]

Common Name

English

XDEMVY

Brand Name

English

LOTILANER [USAN]

Common Name

English

LOTILANER [MI]

Common Name

English

CREDELIO

Brand Name

English

2-THIOPHENECARBOXAMIDE, 5-((5S)-4,5-DIHYDRO-5-(3,4,5-TRICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-3-ISOXAZOLYL)-3-METHYL-N-(2-OXO-2-((2,2,2-TRIFLUOROETHYL)AMINO)ETHYL)-

Systematic Name

English

3-METHYI-N-(2-OXO-2-((2,2,2-TRIFLUOROETHYL)AMINO)ETHYL)-5-((55)-5-(3,4,5-TRICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1,2-OXAZOL-3-YL)THIOPHENE-2-CARBOXAMIDE

Systematic Name

English

Classification Tree Code System Code

EMA VETERINARY ASSESSMENT REPORTS

CREDELIO (AUTHORISED)