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Status:
Possibly Marketed Outside US
Source:
M016
(2023)
Source URL:
First approved in 2012
Source:
21 CFR 333D
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
21 CFR 355
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 355
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Hesperetin is a cholesterol-lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperetin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again. Hesperetin reduces or inhibits the activity of acyl-coenzyme A: cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels. Hesperetin's 7-O-glycoside, hesperidin, is a naturally occurring flavanon-glycoside, the main flavonoid in lemons and sweet oranges.
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Possibly Marketed Outside US
Source:
ZO MEDICAL BRIGHTALIVE NON-RETINOL SKIN BRIGHTENER by ZO Skin Health, Inc.
(2015)
Source URL:
First approved in 2012
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Both alpha and beta arbutin are known derivatives of hydroquinone and used as depigmenting agents in cosmetic formulations. Alpha-Arbutin has been shown to inhibit melanin synthesis but not the growth of human melanoma cells. Alpha arbutin inhibits tyrosinase with Ki of 2.29 mM, however, Beta-arbutin has a Ki of 0.08 mM.
Status:
Possibly Marketed Outside US
Source:
21 CFR 348
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 348
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
21 CFR 348
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 348
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
21 CFR 350
(2015)
Source URL:
First approved in 2012
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Possibly Marketed Outside US
Source:
21 CFR 348
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 348
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)