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Restrict the search for
beta carotene
to a specific field?
Status:
Investigational
Source:
INN:atigliflozin [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Atigliflozin (also known as AVE2268), a substituted glycopyranoside, is a selective inhibitor of sodium-dependent glucose transporter 2. This drug reached phase II clinical trials as a new antidiabetic drug for the treatment of type 2 diabetes but further development was discontinued.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Razupenem (also known as PZ-601 or PTZ601) is an anti-MRSA carbapenem antibiotic. It is active against Enterobacteriaceae and Gram-positive bacteria including methicillin-resistant staphylococci and enterococci, and was investigated as potential alternative drug (replacing common antibiotics) against resistant bacteria. In healthy male volunteers, razupenem did not cause serious adverse events. The potential effect and safety of razupenem has been evaluated in a phase II clinical trial studying skin infection.
Status:
Investigational
Source:
INN:desocriptine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Desocriptine is an ergot alkaloid (alpha-dihydro-beta-ergocryptine) derivative. It is a combined alpha- and beta-adrenoceptor antagonist. Desocriptine is antihypertensive and antianginal agent.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Minaxolone, a water-soluble steroid anesthetic that was studied in 1970s/1980s. It is a positive allosteric modulator of the GABAA receptor. This compound was withdrawn before registration due to reported toxicity in rats.
Status:
Investigational
Source:
INN:metenkefalin [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Metenkephalin (Met-enkephalin) is an endogenous opioid peptide that acts as an agonist at μ-opioid receptors (μORs) and δ-opioid receptors (δORs). Met-enkephalin exhibits neuromodulatory, antinociceptive/analgesic, antidepressant, and gastrointestinal motility modulating activities. Like other endogenous opioids, met-enkephalin modulates expression of opioid receptors and plays a role in reward/reinforcement signaling. Met-enkephalin is also involved in exercise-induced reversal of neuropathic pain and in animals undergoing the forced swim test, decreases immobility time. Met-enkephalin inhibits gastrointestinal muscle contractility, inhibiting motility and gastric emptying. Additionally, analogs of this peptide display anticancer and antiepileptic/anticonvulsant activities.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
HE3286, a synthetic derivative of androst-5-ene-3β,7β,17β-triol (AET), a non-glucocorticoid anti-inflammatory metabolite of the adrenal steroid, dehydroepiandrosterone is under development by Harbor BioSciences as an anti-inflammatory; antiepileptic drugs; antihyperglycemic agent. HE3286 was studied in phase I clinical trials in Obese Adult Subjects, in Patients With Rheumatoid Arthritis in Patients With Active, Mild-to-Moderate Ulcerative Colitis, and in Patients With Type 2 Diabetes Mellitus. In all these studies were determined safety, tolerance, pharmacokinetics, and activity of HE3286. In addition, was shown that HE3286 acted via binding, regulation and/or activation of MAPK or ERK, or through modulation of NFκB. Experiments on animals have shown that the drug could have a neuroprotective influence in glaucoma, as well as other chronic neurodegenerations.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conorphone (TR5109) is an opioid of mixed agonist-antagonist analgesic class. In animal models, conorphone demonstrated an analgesic activity in the same range as morphine, and lack of addiction liability. Conoprphone was evaluated in a clinical trial for postoperative pain in the oral surgery model and in patients with postepisiotomy pain. The 40 mg dose of conorphone resulted in a significant incidence of side effects such as drowsiness, dizziness, nausea, and vomiting.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Iliparcil was developed as an orally active beta-D-xyloside venous antithrombotic agent. However, the preclinical studies of this compound were discontinued.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Stenbolone is an anabolic–androgenic steroid of the dihydrotestosterone group patented by Schering AG but never marketed. Ester prodrug of stenbolone is used as an anabolic–androgenic steroid for depot intramuscular injection under the brand names Anatrofin and Stenobolone.
Class (Stereo):
CHEMICAL (RACEMIC)
Idropranolol is a beta–adrenoceptor blocking agent that has never been marketed.
