Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H29NO3 |
| Molecular Weight | 367.4813 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]15CCN(CC6CC6)[C@H](C4)[C@]5([H])[C@@H](CC)CC2=O
InChI
InChIKey=JMPUQJQXECRLKY-IKADHJCRSA-N
InChI=1S/C23H29NO3/c1-3-14-11-17(25)22-23-8-9-24(12-13-4-5-13)16(19(14)23)10-15-6-7-18(26-2)21(27-22)20(15)23/h6-7,13-14,16,19,22H,3-5,8-12H2,1-2H3/t14-,16+,19-,22-,23-/m0/s1
| Molecular Formula | C23H29NO3 |
| Molecular Weight | 367.4813 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Conorphone (TR5109) is an opioid of mixed agonist-antagonist analgesic class. In animal models, conorphone demonstrated an analgesic activity in the same range as morphine, and lack of addiction liability. Conoprphone was evaluated in a clinical trial for postoperative pain in the oral surgery model and in patients with postepisiotomy pain. The 40 mg dose of conorphone resulted in a significant incidence of side effects such as drowsiness, dizziness, nausea, and vomiting.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:13:41 GMT 2023
by
admin
on
Fri Dec 15 17:13:41 GMT 2023
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| Record UNII |
9H58696D23
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C241
Created by
admin on Fri Dec 15 17:13:41 GMT 2023 , Edited by admin on Fri Dec 15 17:13:41 GMT 2023
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| Code System | Code | Type | Description | ||
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72060-05-0
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5361887
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4853
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9H58696D23
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SUB06804MIG
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DTXSID50101649
Created by
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C025489
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CHEMBL2110790
Created by
admin on Fri Dec 15 17:13:41 GMT 2023 , Edited by admin on Fri Dec 15 17:13:41 GMT 2023
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100000084267
Created by
admin on Fri Dec 15 17:13:41 GMT 2023 , Edited by admin on Fri Dec 15 17:13:41 GMT 2023
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C79935
Created by
admin on Fri Dec 15 17:13:41 GMT 2023 , Edited by admin on Fri Dec 15 17:13:41 GMT 2023
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Conorfone
Created by
admin on Fri Dec 15 17:13:41 GMT 2023 , Edited by admin on Fri Dec 15 17:13:41 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
