CONORPHONE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H29NO3.ClH
Molecular Weight	403.942
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.[H][C@]12[C@@H](CC)CC(=O)[C@@H]3OC4=C5C(C[C@H]1N(CC6CC6)CC[C@@]235)=CC=C4OC

InChI

InChIKey=CKEXIRBGGMFWOA-AVQDSJIMSA-N

InChI=1S/C23H29NO3.ClH/c1-3-14-11-17(25)22-23-8-9-24(12-13-4-5-13)16(19(14)23)10-15-6-7-18(26-2)21(27-22)20(15)23;/h6-7,13-14,16,19,22H,3-5,8-12H2,1-2H3;1H/t14-,16+,19-,22-,23-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C23H29NO3
Molecular Weight	367.4813
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6597688 | https://www.ncbi.nlm.nih.gov/pubmed/121369 | https://www.researchgate.net/publication/322773868_Xorphanol_and_conorphone_analgesia_after_episiotomy

Conorphone (TR5109) is an opioid of mixed agonist-antagonist analgesic class. In animal models, conorphone demonstrated an analgesic activity in the same range as morphine, and lack of addiction liability. Conoprphone was evaluated in a clinical trial for postoperative pain in the oral surgery model and in patients with postepisiotomy pain. The 40 mg dose of conorphone resulted in a significant incidence of side effects such as drowsiness, dizziness, nausea, and vomiting.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:36:51 GMT 2023` Edited by `admin` on `Fri Dec 15 15:36:51 GMT 2023`
Record UNII	NN00W8BQ8N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CONORPHONE HYDROCHLORIDE

Official Name

English

TR-5109

Code

English

MORPHINAN-6-ONE, 17-(CYCLOPROPYLMETHYL)-4,5-EPOXY-8-ETHYL-3-METHOXY-, HYDROCHLORIDE, (5.ALPHA.,8.BETA.)-

Systematic Name

English

17-(Cyclopropylmethyl)-4,5α-epoxy-8β-ethyl-3-methoxymorphinan-6-one hydrochloride

Systematic Name

English

CONORPHONE HCL

Common Name

English

CONORFONE HYDROCHLORIDE

Common Name

English

CONORPHONE HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67413