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Restrict the search for
telotristat ethyl
to a specific field?
Status:
Investigational
Source:
INN:bentipimine [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Bentipimine was developed as an anticholinergic agent.
Status:
Investigational
Source:
INN:mobenzoxamine [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Mobenzoxamine is gastro-intestinal function modulator, that enhanced gastric emptying. In preclinical models clathrate compound of mobenzoxamine with beta-cyclodextrin showed a clear amelioration of the delayed gastric emptying induced by Barium chloride. On isolated guinea pig ileum, Mobenzoxamine inhibited contractions induced by various agonists equally to or more potently than trimebutine or papaverine.
Status:
Investigational
Source:
NCT04182126: Not Applicable Interventional Completed LLIN, PBO LLIN, IRS, Larviciding
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (RACEMIC)
Methetoin, a neuropsychiatric agent possesses anticonvulsive properties. Information about the current use of this compound is not available.
Class (Stereo):
CHEMICAL (RACEMIC)
Norbolethone is a 19-nor anabolic steroid first synthesized in 1966. During the 1960s it was administered to humans in efficacy studies concerned with short stature and underweight conditions. It has never been reported by doping control laboratories prior to 2001. Norbolethone matches the description for what is described as a "designer steroid. " In fact, Norbolethone was given in clinical trials over 30 years ago and never given the green light. No supply was ever manufactured, and no test was ever developed to detect this substance, yet ironically, it was suspected of being used in the 2000 Olympics based on blood and urine assays done by the IOC. Norbolethone was used in the treatment of idiopathic underweight, prevention of indomethacin-induced intestinal ulcers.
Class (Stereo):
CHEMICAL (UNKNOWN)
Targets:
Igmesine is a sigma-1 receptor agonist. It was assayed in clinical trials targeting major depressive disorder. Igmesine is the only antisecretory agent that we have tested to date that inhibits both cholera toxin and the E. coli enterotoxins. Sigma receptors are known to be present on nerves in the enteric nervous system and this would seem to be a potentially useful class of drugs to pursue for the treatment of secretory diarrhoea in humans. It was shown that when Alzheimer's disease rats were submitted to the conditioned fear stress test, igmesine can significantly reduce the stress-induced motor suppression, indicating exogenous σ-1 receptor agonists may alleviate Alzheimer's disease-associated depressive symptoms.
Status:
Investigational
Source:
NCT00344812: Phase 2 Interventional Completed Opioid Dependence
(1996)
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Dimepheptanol is one of the phenylpiperidine series, an opioid receptor agonist, which is active as an opioid analgesic. It is also elaborated in a number of close analogues, derivatives or diastereoisomers with similar properties. Dimepheptanol is a synthetic narcotic analgesic that has no accepted medical use in the United States.
Class (Stereo):
CHEMICAL (RACEMIC)
Secoverine is a selective muscarinic receptor antagonist that was studied as a neurotropic spasmolytic agent. It was shown that the drug had no nicotinolytic or antihistaminic activity, a moderate antisterotonic activity, an inhibiting effect on the noradrenaline uptake mechanism of the vas deferens and marked local anesthetic activity.
Status:
Investigational
Source:
NCT01063920: Phase 2/Phase 3 Interventional Completed Osteoarthritis
(2010)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of the non-steroidal anti-inflammatory drug (NSAID) naproxen that is hydrolysed to pharmacologically active naproxen once absorbed. Naproxen etemesil was in development with Logical Therapeutics for the treatment of osteoarthritis. However, no recent development has been reported. It is also in phase I clinical trials for the treatment of inflammation and arthritis.The compound was originally developed by Medinox, licensed to Logical Therapeutics in 2006 for partial rights.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Nafenodone [LU 39821] is a potent and selective inhibitor of norepinephrine and serotonin uptake. Its development for the treatment of anxiety disorders, major depressive disorder and psychotic disorders has been discontinued.
