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Search results for nonoxynol root_version in Record Version (approximate match)
Status:
US Previously Marketed
Source:
LARGON by HIKMA
(1960)
Source URL:
First approved in 1960
Source:
LARGON by HIKMA
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Propiomazine is a typical antipsychotic, blocking H1 receptors and is primarily indicated in conditions Insomnia. Propiomazine was also used under brand name largon for the relief of restlessness and apprehension, preoperatively or during surgery. In addition largon was used as an adjunct to analgesics for the relief of restlessness and apprehension during labor. But this drug was discontinued.
Status:
US Previously Marketed
First approved in 1960
Class (Stereo):
CHEMICAL (ACHIRAL)
Lucanthone is a thioxanthenone DNA intercalator. It inhibits topoisomerases and the dual function base excision repair enzyme apurinic endonuclease 1. Lucanthone has been devised for the treatment of schistosomiasis. It is also an antitumor agent. Lucanthone was being developed by Spectrum Pharmaceuticals for the treatment of malignant brain tumours.
Status:
First approved in 1960
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
PROTHIPENDYL is a neuroleptic azaphenothiazine used to treat anxiety and agitation in psychotic syndromes. It also shows strong antihistamine and anti-emetic actions.
Status:
US Previously Marketed
First approved in 1959
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Chlorphenoxamine is an antihistamine and anticholinergic used as an antipruritic and was formerly used in the sympathomimetic treatment of parkinsonism. Histamine receptor H1 antagonist. Chlorphenoxamine is used to treat Allergic conditions, it is reported as an ingredient of Systral in Germany, Malta, Portugal, Thailand, Turkey.
Status:
US Previously Marketed
Source:
OSTENSIN by WYETH
(1961)
Source URL:
First approved in 1959
Class (Stereo):
CHEMICAL (UNKNOWN)
Trimethidinium is a bisquaternary amine ganglion blocking agent with antihypertensive actions. Administration of the drug results in a decrease in blood pressure in the systemic and pulmonary arteries and the right atrium. Associated with these decreased pressures, the stroke volume decreased, but there was sufficient increase in cardiac rate so that cardiac output did not change significantly. Both right and left ventricular work decreased significantly while left ventricular myocardial oxygen consumption was unchanged and calculated cardiac efficiency decreased. Associated side effects on the gastrointestinal tract are reported to be mild and easily controlled when compared with those of pentapyrrolidinium and mecamylamine.
Status:
US Previously Marketed
Source:
TRIBURON TRICLOBISONIUM CHLORIDE by ROCHE
(1961)
Source URL:
First approved in 1959
Class (Stereo):
CHEMICAL (MIXED)
Conditions:
TRICLOBISONIUM (as a chloride salt) is an antibacterial agent used for the treatment and/or prevention of local infections.
Status:
First approved in 1959
Class (Stereo):
CHEMICAL (ACHIRAL)
Piperilate is an antispasmodic, antimuscarinic agent. It is a muscarinic cholinergic receptor antagonist.
Status:
US Previously Marketed
Source:
CAPSEBON by PITMAN MOORE
(1961)
Source URL:
First approved in 1958
Class (Stereo):
CHEMICAL (ACHIRAL)
Cadmium is a heavy metal that causes toxicity in humans and animals. Cadmium chloride is used due to its solubility in water and its ability to produce high concentrations of cadmium at the target site. Cadmium chloride is used in printing, photocopying, dyeing, analytical chemistry. Experiments on rodents have shown that this compound caused renal toxicity. Oxidative stress plays a key role in cadmium chloride-induced cyto/genotoxicity.
Status:
First approved in 1957
Class (Stereo):
CHEMICAL (ABSOLUTE)
LEVAMFETAMINE the levorotatory form of amphetamine. L-amphetamine, is a central nervous system (CNS) stimulant known to increase wakefulness and concentration in association with decreased appetite and fatigue. Pharmaceuticals that contain levoamphetamine are currently indicated and prescribed for the treatment of attention deficit hyperactivity disorder (ADHD), obesity, and narcolepsy in some countries. L-Amphetamine succinate was sold in Hungary between 1952 and 1955 under the brand name Cydril.
Status:
US Previously Marketed
Source:
PROPOXYPHENE HYDROCHLORIDE by ALRA
(1982)
Source URL:
First approved in 1957
Source:
DARVON by XANODYNE PHARM
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Propoxyphene is a centrally acting opiate analgesic. Propoxyphene is an odorless, freely soluble in water, white crystalline powder with a bitter taste. In vitro studies demonstrated propoxyphene and the metabolite norpropoxyphene inhibit sodium channels (local anesthetic effect) with norpropoxyphene being approximately 2 fold more potent than propoxyphene and propoxyphene approximately 10 fold more potent than lidocaine. Propoxyphene and norpropoxyphene inhibit the voltage-gated potassium current carried by cardiac rapidly activating delayed rectifier (hERG) channels with approximately equal potency. It is unclear if the effects on ion channels occur within therapeutic dose range. Propoxyphene is indicated for the relief of mild to moderate pain.