Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C20H24N2OS.C4H4O4 |
| Molecular Weight | 456.555 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C/C(O)=O.CCC(=O)C1=CC=C2SC3=C(C=CC=C3)N(CC(C)N(C)C)C2=C1
InChI
InChIKey=ILEKKZUHFYUQIE-BTJKTKAUSA-N
InChI=1S/C20H24N2OS.C4H4O4/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20;5-3(6)1-2-4(7)8/h6-12,14H,5,13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Propiomazine is a typical antipsychotic, blocking H1 receptors and is primarily indicated in conditions Insomnia. Propiomazine was also used under brand name largon for the relief of restlessness and apprehension, preoperatively or during surgery. In addition largon was used as an adjunct to analgesics for the relief of restlessness and apprehension during labor. But this drug was discontinued.
Approval Year
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
7.7 h |
20 mg single, intravenous dose: 20 mg route of administration: Intravenous experiment type: SINGLE co-administered: |
PROPIOMAZINE serum | Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
|
10.8 h |
single, intramuscular |
PROPIOMAZINE serum | Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
|
8.6 h |
single, oral |
PROPIOMAZINE serum | Homo sapiens population: HEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Funbound
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
19% |
PROPIOMAZINE plasma | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Sample Use Guides
Usual adult dose: Preoperative: intramuscular or intravenous: 20 to 40 mg administered in conjunction with 50 mg of meperidine. Sedation during surgery with local, nerve block, or spinal anesthesia: intramuscular or intravenous 10 to 20 mg. Analgesia adjunct, during labor: intramuscular or intravenous, 20 to 40 mg in the early stages of labor, then 20 to 40 mg of propiomazine administered in conjunction with 25 to 75 mg of meperidine when labor is definitely established. Doses may be repeated every three hours, if necessary.
Usual pediatric dose: sedation prior to surgery: preanesthetic or postoperative: children up to 27 kg: Intramuscular or intravenous, 550 mcg (0.55 mg) to 1.1 mg per kg of body; children 2 to 4 years of age: Intramuscular or intravenous, 10 mg; children 4 to 6 years of age: Intramuscular or intravenous, 15 mg; children 6 to 12 years of age: Intramuscular or intravenous, 25 mg.
insomnia: 25 to 50 mg oral
Route of Administration:
Other
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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3568-23-8
Created by
admin on Sat Dec 16 04:41:36 GMT 2023 , Edited by admin on Sat Dec 16 04:41:36 GMT 2023
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222-661-6
Created by
admin on Sat Dec 16 04:41:36 GMT 2023 , Edited by admin on Sat Dec 16 04:41:36 GMT 2023
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SUB04084MIG
Created by
admin on Sat Dec 16 04:41:36 GMT 2023 , Edited by admin on Sat Dec 16 04:41:36 GMT 2023
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OEY0ZC43SA
Created by
admin on Sat Dec 16 04:41:36 GMT 2023 , Edited by admin on Sat Dec 16 04:41:36 GMT 2023
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100000091522
Created by
admin on Sat Dec 16 04:41:36 GMT 2023 , Edited by admin on Sat Dec 16 04:41:36 GMT 2023
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5702109
Created by
admin on Sat Dec 16 04:41:36 GMT 2023 , Edited by admin on Sat Dec 16 04:41:36 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
