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Details

Stereochemistry RACEMIC
Molecular Formula C20H24N2OS
Molecular Weight 340.4842
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPIOMAZINE

SMILES

CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c3ccccc3S2

InChI

InChIKey=UVOIBTBFPOZKGP-UHFFFAOYSA-N
InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3

HIDE SMILES / InChI

Molecular Formula C20H24N2OS
Molecular Weight 340.4842
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Propiomazine is a typical antipsychotic, blocking H1 receptors and is primarily indicated in conditions Insomnia. Propiomazine was also used under brand name largon for the relief of restlessness and apprehension, preoperatively or during surgery. In addition largon was used as an adjunct to analgesics for the relief of restlessness and apprehension during labor. But this drug was discontinued.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL231
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
LARGON

Approved Use

Unknown

Launch Date

-2.86329602E11
Palliative
LARGON

Approved Use

Unknown

Launch Date

-2.86329602E11
Primary
Unknown

Approved Use

Unknown
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
7.7 h
20 mg single, intravenous
dose: 20 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
PROPIOMAZINE serum
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
10.8 h
single, intramuscular
PROPIOMAZINE serum
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
8.6 h
single, oral
PROPIOMAZINE serum
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
19%
PROPIOMAZINE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
PubMed

PubMed

TitleDatePubMed
[Treatment of sleep disorders during pregnancy and breast feeding].
2006 Oct 4-10
Are sedatives and hypnotics associated with increased suicide risk of suicide in the elderly?
2009 Jun 4
Socioeconomic determinants of psychotropic drug utilisation among elderly: a national population-based cross-sectional study.
2010 Mar 9
Patents

Patents

Sample Use Guides

Usual adult dose: Preoperative: intramuscular or intravenous: 20 to 40 mg administered in conjunction with 50 mg of meperidine. Sedation during surgery with local, nerve block, or spinal anesthesia: intramuscular or intravenous 10 to 20 mg. Analgesia adjunct, during labor: intramuscular or intravenous, 20 to 40 mg in the early stages of labor, then 20 to 40 mg of propiomazine administered in conjunction with 25 to 75 mg of meperidine when labor is definitely established. Doses may be repeated every three hours, if necessary. Usual pediatric dose: sedation prior to surgery: preanesthetic or postoperative: children up to 27 kg: Intramuscular or intravenous, 550 mcg (0.55 mg) to 1.1 mg per kg of body; children 2 to 4 years of age: Intramuscular or intravenous, 10 mg; children 4 to 6 years of age: Intramuscular or intravenous, 15 mg; children 6 to 12 years of age: Intramuscular or intravenous, 25 mg. insomnia: 25 to 50 mg oral
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 02:05:26 UTC 2021
Edited
by admin
on Sat Jun 26 02:05:26 UTC 2021
Record UNII
242Z0PM79Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROPIOMAZINE
HSDB   INN   MART.   MI   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
2-PROPIONYL-10-(2-(DIMETHYLAMINO)PROPYL)PHENOTHIAZINE
Systematic Name English
PROPIOMAZINE [VANDF]
Common Name English
PROPIOMAZINE [MART.]
Common Name English
PROPIOMAZINE [USAN]
Common Name English
CB-1678
Code English
PROPIOMAZINE [INN]
Common Name English
PROPIOMAZINE [MI]
Common Name English
PROPIOMAZINE [HSDB]
Common Name English
PROPIOMAZINE [WHO-DD]
Common Name English
WY-1359
Code English
1-(10-(2-(DIMETHYLAMINO)PROPYL)PHENOTHIAZIN-2-YL)-1-PROPANONE
Systematic Name English
CB 1678
Code English
1-PROPANONE, 1-(10-(2-(DIMETHYLAMINO)PROPYL)-10H-PHENOTHIAZIN-2-YL)-
Systematic Name English
(+/-)-PROPIOMAZINE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29710
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
WHO-ATC N05CM06
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
WHO-VATC QN05CM06
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
Code System Code Type Description
ChEMBL
CHEMBL1201210
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
FDA UNII
242Z0PM79Y
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
DRUG BANK
DB00777
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
RXCUI
8770
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY RxNorm
EVMPD
SUB10110MIG
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
CAS
88245-06-1
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
SUPERSEDED
EPA CompTox
362-29-8
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
ECHA (EC/EINECS)
206-646-1
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
DRUG CENTRAL
2298
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
HSDB
3275
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
NCI_THESAURUS
C66486
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
INN
735
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
PUBCHEM
4940
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
MESH
C084591
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
MERCK INDEX
M9206
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
PROPIOMAZINE
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
IUPHAR
7284
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
CAS
362-29-8
Created by admin on Sat Jun 26 02:05:26 UTC 2021 , Edited by admin on Sat Jun 26 02:05:26 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY