U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 821 - 830 of 967 results


Class (Stereo):
CHEMICAL (ACHIRAL)

Myristyl Alcohol is a fatty alcohol used as an emollient in cosmetics and skin care products also serve as a basic component and solubility aid in metalworking fluids. Contact sensitization to myristyl alcohol has been reported, mostly in case reports or small test series, in patients with contact dermatitis due to cosmetics or medical ointments. 1-Tetradecanol may be prepared by the hydrogenation of myristic acid (or its esters); myristic acid itself can be found in nutmeg (from where it gains its name) but is also present in palm kernel oil and coconut oil and it is from these that the majority of Myristyl Alcohol is produced. Myristyl Alcohol may also be produced from petrochemical feedstocks via either the Ziegler process or hydroformylation.
Dichlorobenzyl alcohol has broad-spectrum activity as an antimicrobial agent and is used in cosmetics and pharmaceuticals. Dichlorobenzyl alcohol has antimicrobial effect against 115 strains of dental plaque. Dichlorobenzyl alcohol inhibited growth of microorganisms but showed highest activity against A. actinomycetemcomitans and Por. gingivalis, organisms related to juvenile and destructive forms of periodontitis. It is a common ingredient in throat lozenges such as Neo angin, Strepsils, Lorsept, and Gorpils. A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and severe acute respiratory syndrome coronavirus (SARS-CoV).
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Oleyl alcohol (also octadecenol or cis-9-octadecen-1-ol) is a non-ionic, unsaturated fatty alcohol. Oleyl alcohol is a long-chain aliphatic alcohol that occurs naturally in fish oils. It is used in such large-scale applications as the softening and lubrication of textile fabrics, and the production of carbon paper, stencil paper, and printing ink. Oleyl alcohol is also utilized as an antifoam agent and cutting lubricant. It also is a precursor for the preparation of its sulfuric ester derivatives, which are used in detergents and wetting agents. Oleyl alcohol has been incorporated into various formulations for drug delivery. Oleyl alcohol is found in a wide variety of products such as hair conditioners, foundations, eye makeup, skin moisturizers, skin cleansers and other skin care products. Oleyl alcohol helps to form emulsions and prevents an emulsion from separating into its oil and liquid components. It also reduces the tendency of finished products to generate foam when shaken. When used in the formulation of skin care products, Oleyl alcohol acts as a lubricant on the skin surface, which gives the skin a soft, smooth appearance.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Ethyl valerate is a substance responsible for green apple flavor. It has various applications in the food and cosmetic industry.
Status:
Possibly Marketed Outside US
Source:
NCT03355846: Phase 4 Interventional Completed Acute Anal Fissure
(2018)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Methylchloroisothiazolinone is an active ingredient in many preservatives marketed under various brand names. It is effective against gram-positive and gram-negative bacteria, yeast, and fungi. Pure Methylchloroisothiazolinone is not commercially available. Kathon CG contains a mixture of Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) in ratio 3:1. Kathon was used in various rinse-off and leave-on formulations including hair products, shampoos, skin care products, bath products, eye and facial makeup, wet wipes and suntan products. The Commission envisages amending Annex V of the Cosmetics Regulation (EC) No. 1223/2009 to restrict the use of methylchloroisothiazolinone to rinse-off products, as suggested by the SCCS.

Showing 821 - 830 of 967 results