| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H4ClNOS |
| Molecular Weight | 149.599 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1SC(Cl)=CC1=O
InChI
InChIKey=DHNRXBZYEKSXIM-UHFFFAOYSA-N
InChI=1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3
| Molecular Formula | C4H4ClNOS |
| Molecular Weight | 149.599 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Methylchloroisothiazolinone is an active ingredient in many preservatives marketed under various brand names. It is effective against gram-positive and gram-negative bacteria, yeast, and fungi. Pure Methylchloroisothiazolinone is not commercially available. Kathon CG contains a mixture of Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) in ratio 3:1. Kathon was used in various rinse-off and leave-on formulations including hair products, shampoos, skin care products, bath products, eye and facial makeup, wet wipes and suntan products. The Commission envisages amending Annex V of the Cosmetics Regulation (EC) No. 1223/2009 to restrict the use of methylchloroisothiazolinone to rinse-off products, as suggested by the SCCS.
Originator
Approval Year
Doses
AEs
PubMed
Patents
Sample Use Guides
3 mcg of 5-chloro-2-methyl-4-isothiazolin-3-one (1.05% to 1.25% w/w) and 2-methyl-4-isothiazolin-3-one (0.25% to 0.40%w/w) in a 3:1 ratio per patch. Schedule patients to return approximately 48 hours after patch test application to have the panels removed.
Route of Administration:
Topical
5-Chloro-2-methyl-4-isothiazolin-3-one inhibited growth in all test strains of Salmonella typhimurium without activation. A statistically significant increase in the number of revertants in strain TA100 was observed without activation at concentrations of 0.20, 0.25 and 0.30 ug/plate and in 2 of the 3 trials at 0.10 ug/plate.
