Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H6Cl2O |
Molecular Weight | 177.028 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC1=C(Cl)C=C(Cl)C=C1
InChI
InChIKey=DBHODFSFBXJZNY-UHFFFAOYSA-N
InChI=1S/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/7887143Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/15889535
https://books.google.ru/books?id=3f-kPJ17_TYC&pg=PA243&lpg=PA243&dq=dichlorobenzyl+alcohol+was+developed&source=bl&ots=KmGpJt-QM6&sig=vgHUtE_8Bv3vWZpbHj4LVuyAPdM&hl=ru&sa=X&ved=0ahUKEwi5vaW4g9_PAhUoJJoKHfXSAOI4ChDoAQghMAE#v=onepage&q=dichlorobenzyl%20alcohol%20was%20developed&f=false
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7887143
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/15889535
https://books.google.ru/books?id=3f-kPJ17_TYC&pg=PA243&lpg=PA243&dq=dichlorobenzyl+alcohol+was+developed&source=bl&ots=KmGpJt-QM6&sig=vgHUtE_8Bv3vWZpbHj4LVuyAPdM&hl=ru&sa=X&ved=0ahUKEwi5vaW4g9_PAhUoJJoKHfXSAOI4ChDoAQghMAE#v=onepage&q=dichlorobenzyl%20alcohol%20was%20developed&f=false
Dichlorobenzyl alcohol has broad-spectrum activity as an antimicrobial agent and is used in cosmetics and pharmaceuticals. Dichlorobenzyl alcohol has antimicrobial effect against 115 strains of dental plaque. Dichlorobenzyl alcohol inhibited growth of microorganisms but showed highest activity against A. actinomycetemcomitans and Por. gingivalis, organisms related to juvenile and destructive forms of periodontitis. It is a common ingredient in throat lozenges such as Neo angin, Strepsils, Lorsept, and Gorpils. A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and severe acute respiratory syndrome coronavirus (SARS-CoV).
Approval Year
Sample Use Guides
In Vivo Use Guide
Curator's Comment: 1 tablet contains the active substances: 2,4-dichlorobenzyl alcohol 1.2 mg, 0.6 mg amylmetacresol, levomenthol 5.72 mg and ingredients: oil of anise, peppermint oil, maltitol (lycasin), tartaric acid , cochineal red A (E124).
NEO-Angin. For adults and children over 6 years of age take 1 tablet every 2-3 hours.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7887143
For microbial susceptibility testing dichlorobenzyl alcohol was dissolved in 70% w/v of propylene glycol. It was added to the first medium (see below) by filter sterilization, as a twofold dilution.
All strains were anaerobically cultivated
in fluid brain-heart infusion (BHI, Difco).
Spirochetes were cultivated in BHI supplemented
by 15% inactivated rabbit serum, 0.07% Noble agar, and 5 ug/ml of cocarboxylase. Spirochetes were incubated at 37°C for 4 days; all other strains were incubated at 37°C for 2 days. All organisms were approximately equally
susceptible to dichlorobenzyl alcohol. The
most susceptible strain was the reference
strain of A. actinomycetemcomitans, with an
MIC of 723 uM. Oral isolates of A. actinomycetemcomitans, C. albicans, Por. gingivalis, and two strains of Tr. socranskii had
MIC values of 1,446 uM. MICs for all other strains were 2,892-5,784 uM.
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-ATC |
R02AA03
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
||
|
WHO-VATC |
QR02AA03
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
||
|
EPA PESTICIDE CODE |
31109
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
||
|
NCI_THESAURUS |
C28394
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
100000092427
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
1483469
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
217-210-5
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
48220
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
1NKX3648J9
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
C008396
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
SUB13566MIG
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
CHEMBL3184437
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
15684
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
1NKX3648J9
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
m4339
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | Merck Index | ||
|
2,4-DICHLOROBENZYL ALCOHOL
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
22906
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | RxNorm | ||
|
15635
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
DTXSID9041362
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
3140
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
1777-82-8
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
C77047
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY | |||
|
DB13269
Created by
admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
|
PRIMARY |
ACTIVE MOIETY