U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H6Cl2O
Molecular Weight 177.028
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICHLOROBENZYL ALCOHOL

SMILES

OCC1=C(Cl)C=C(Cl)C=C1

InChI

InChIKey=DBHODFSFBXJZNY-UHFFFAOYSA-N
InChI=1S/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/15889535 https://books.google.ru/books?id=3f-kPJ17_TYC&pg=PA243&lpg=PA243&dq=dichlorobenzyl+alcohol+was+developed&source=bl&ots=KmGpJt-QM6&sig=vgHUtE_8Bv3vWZpbHj4LVuyAPdM&hl=ru&sa=X&ved=0ahUKEwi5vaW4g9_PAhUoJJoKHfXSAOI4ChDoAQghMAE#v=onepage&q=dichlorobenzyl%20alcohol%20was%20developed&f=false

Dichlorobenzyl alcohol has broad-spectrum activity as an antimicrobial agent and is used in cosmetics and pharmaceuticals. Dichlorobenzyl alcohol has antimicrobial effect against 115 strains of dental plaque. Dichlorobenzyl alcohol inhibited growth of microorganisms but showed highest activity against A. actinomycetemcomitans and Por. gingivalis, organisms related to juvenile and destructive forms of periodontitis. It is a common ingredient in throat lozenges such as Neo angin, Strepsils, Lorsept, and Gorpils. A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and severe acute respiratory syndrome coronavirus (SARS-CoV).

Approval Year

Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Efficacy of three surface disinfectants for dental radiographic films and gloves.
2004 Jul
Allergic contact dermatitis from dichlorobenzyl alcohol in a patient with multiple contact allergies.
2009 May
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: 1 tablet contains the active substances: 2,4-dichlorobenzyl alcohol 1.2 mg, 0.6 mg amylmetacresol, levomenthol 5.72 mg and ingredients: oil of anise, peppermint oil, maltitol (lycasin), tartaric acid , cochineal red A (E124).
NEO-Angin. For adults and children over 6 years of age take 1 tablet every 2-3 hours.
Route of Administration: Oral
In Vitro Use Guide
For microbial susceptibility testing dichlorobenzyl alcohol was dissolved in 70% w/v of propylene glycol. It was added to the first medium (see below) by filter sterilization, as a twofold dilution. All strains were anaerobically cultivated in fluid brain-heart infusion (BHI, Difco). Spirochetes were cultivated in BHI supplemented by 15% inactivated rabbit serum, 0.07% Noble agar, and 5 ug/ml of cocarboxylase. Spirochetes were incubated at 37°C for 4 days; all other strains were incubated at 37°C for 2 days. All organisms were approximately equally susceptible to dichlorobenzyl alcohol. The most susceptible strain was the reference strain of A. actinomycetemcomitans, with an MIC of 723 uM. Oral isolates of A. actinomycetemcomitans, C. albicans, Por. gingivalis, and two strains of Tr. socranskii had MIC values of 1,446 uM. MICs for all other strains were 2,892-5,784 uM.
Name Type Language
DICHLOROBENZYL ALCOHOL
II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
DICHLOROBENZYL ALCOHOL [INCI]
Common Name English
Dichlorobenzyl alcohol [WHO-DD]
Common Name English
DICHLOROBENZYL ALCOHOL [MI]
Common Name English
DICHLOROBENZYL ALCOHOL [II]
Common Name English
DICHLOROBENZYL ALCOHOL [MART.]
Common Name English
DYBENAL
Brand Name English
OXICONAZOLE RELATED COMPOUND D [USP-RS]
Common Name English
DICHLOROBENZYL ALCOHOL [VANDF]
Common Name English
2,4-DICHLOROBENZYL ALCOHOL
Systematic Name English
RAPIDOSEPT
Brand Name English
BENZYL ALCOHOL, 2,4-DICHLORO-
Systematic Name English
NSC-15635
Code English
2,4-DICHLOROBENZYL ALCOHOL [EP MONOGRAPH]
Common Name English
2,4-DICHLOROBENZENEMETHANOL
Systematic Name English
Classification Tree Code System Code
WHO-ATC R02AA03
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
WHO-VATC QR02AA03
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
EPA PESTICIDE CODE 31109
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
Code System Code Type Description
SMS_ID
100000092427
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
RS_ITEM_NUM
1483469
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
ECHA (EC/EINECS)
217-210-5
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
CHEBI
48220
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
FDA UNII
1NKX3648J9
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
MESH
C008396
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
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EVMPD
SUB13566MIG
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
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ChEMBL
CHEMBL3184437
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
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PUBCHEM
15684
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
DAILYMED
1NKX3648J9
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
MERCK INDEX
m4339
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
2,4-DICHLOROBENZYL ALCOHOL
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
RXCUI
22906
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY RxNorm
NSC
15635
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
EPA CompTox
DTXSID9041362
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
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DRUG CENTRAL
3140
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
CAS
1777-82-8
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
NCI_THESAURUS
C77047
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY
DRUG BANK
DB13269
Created by admin on Fri Dec 15 15:09:03 GMT 2023 , Edited by admin on Fri Dec 15 15:09:03 GMT 2023
PRIMARY