Stereochemistry | ACHIRAL |
Molecular Formula | C7H6Cl2O |
Molecular Weight | 177.028 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC1=C(Cl)C=C(Cl)C=C1
InChI
InChIKey=DBHODFSFBXJZNY-UHFFFAOYSA-N
InChI=1S/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2
Molecular Formula | C7H6Cl2O |
Molecular Weight | 177.028 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Dichlorobenzyl alcohol has broad-spectrum activity as an antimicrobial agent and is used in cosmetics and pharmaceuticals. Dichlorobenzyl alcohol has antimicrobial effect against 115 strains of dental plaque. Dichlorobenzyl alcohol inhibited growth of microorganisms but showed highest activity against A. actinomycetemcomitans and Por. gingivalis, organisms related to juvenile and destructive forms of periodontitis. It is a common ingredient in throat lozenges such as Neo angin, Strepsils, Lorsept, and Gorpils. A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and severe acute respiratory syndrome coronavirus (SARS-CoV).
Approval Year
PubMed
Patents
Sample Use Guides
NEO-Angin. For adults and children over 6 years of age take 1 tablet every 2-3 hours.
Route of Administration:
Oral
For microbial susceptibility testing dichlorobenzyl alcohol was dissolved in 70% w/v of propylene glycol. It was added to the first medium (see below) by filter sterilization, as a twofold dilution.
All strains were anaerobically cultivated
in fluid brain-heart infusion (BHI, Difco).
Spirochetes were cultivated in BHI supplemented
by 15% inactivated rabbit serum, 0.07% Noble agar, and 5 ug/ml of cocarboxylase. Spirochetes were incubated at 37°C for 4 days; all other strains were incubated at 37°C for 2 days. All organisms were approximately equally
susceptible to dichlorobenzyl alcohol. The
most susceptible strain was the reference
strain of A. actinomycetemcomitans, with an
MIC of 723 uM. Oral isolates of A. actinomycetemcomitans, C. albicans, Por. gingivalis, and two strains of Tr. socranskii had
MIC values of 1,446 uM. MICs for all other strains were 2,892-5,784 uM.