DICHLOROBENZYL ALCOHOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6Cl2O
Molecular Weight	177.028
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCC1=CC=C(Cl)C=C1Cl

InChI

InChIKey=DBHODFSFBXJZNY-UHFFFAOYSA-N

InChI=1S/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2

HIDE SMILES / InChI

Molecular Formula	C7H6Cl2O
Molecular Weight	177.028
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7887143
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/15889535 https://books.google.ru/books?id=3f-kPJ17_TYC&pg=PA243&lpg=PA243&dq=dichlorobenzyl+alcohol+was+developed&source=bl&ots=KmGpJt-QM6&sig=vgHUtE_8Bv3vWZpbHj4LVuyAPdM&hl=ru&sa=X&ved=0ahUKEwi5vaW4g9_PAhUoJJoKHfXSAOI4ChDoAQghMAE#v=onepage&q=dichlorobenzyl%20alcohol%20was%20developed&f=false

Dichlorobenzyl alcohol has broad-spectrum activity as an antimicrobial agent and is used in cosmetics and pharmaceuticals. Dichlorobenzyl alcohol has antimicrobial effect against 115 strains of dental plaque. Dichlorobenzyl alcohol inhibited growth of microorganisms but showed highest activity against A. actinomycetemcomitans and Por. gingivalis, organisms related to juvenile and destructive forms of periodontitis. It is a common ingredient in throat lozenges such as Neo angin, Strepsils, Lorsept, and Gorpils. A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and severe acute respiratory syndrome coronavirus (SARS-CoV).

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Acute pharyngitis 2 Sources: https://www.clinicaltrialsregister.eu/ctr-search/trial/2012-002876-15/DE	Primary	Approved 8583	Neo-angin Approved Use Unknown
Upper respiratory tract infections 12 Sources: https://www.clinicaltrialsregister.eu/ctr-search/trial/2008-005059-67/GB	Primary	Phase III 665	Unknown Approved Use Unknown
Dental plaque 13 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7887143	Primary	Basic research	Unknown Approved Use Unknown

Doses

Dose	Population	Adverse events
1.2 mg single, oral Recommended Dose: 1.2 mg Route: oral Route: single Dose: 1.2 mg Sources: https://pubmed.ncbi.nlm.nih.gov/21332976/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/21332976/	Sources: https://pubmed.ncbi.nlm.nih.gov/21332976/

PubMed

Title	Date	PubMed
Topical antiseptics for the treatment of sore throat block voltage-gated neuronal sodium channels in a local anaesthetic-like manner.	2009-08	19367399
Allergic contact dermatitis from dichlorobenzyl alcohol in a patient with multiple contact allergies.	2009-05	19397627
FT-Raman and FT-IR spectra, ab initio and density functional studies of 3,4-dichlorobenzyl alcohol.	2006-11	16574470
A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV.	2005	15889535
Efficacy of three surface disinfectants for dental radiographic films and gloves.	2004-07	15193787
Evaluation of the antimicrobial effects of sodium benzoate and dichlorobenzyl alcohol against dental plaque microorganisms. An in vitro study.	1994-12	7887143

Patents

Sample Use Guides

In Vivo Use Guide

NEO-Angin. For adults and children over 6 years of age take 1 tablet every 2-3 hours.

Route of Administration: Oral

In Vitro Use Guide

For microbial susceptibility testing dichlorobenzyl alcohol was dissolved in 70% w/v of propylene glycol. It was added to the first medium (see below) by filter sterilization, as a twofold dilution. All strains were anaerobically cultivated in fluid brain-heart infusion (BHI, Difco). Spirochetes were cultivated in BHI supplemented by 15% inactivated rabbit serum, 0.07% Noble agar, and 5 ug/ml of cocarboxylase. Spirochetes were incubated at 37°C for 4 days; all other strains were incubated at 37°C for 2 days. All organisms were approximately equally susceptible to dichlorobenzyl alcohol. The most susceptible strain was the reference strain of A. actinomycetemcomitans, with an MIC of 723 uM. Oral isolates of A. actinomycetemcomitans, C. albicans, Por. gingivalis, and two strains of Tr. socranskii had MIC values of 1,446 uM. MICs for all other strains were 2,892-5,784 uM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:48:10 GMT 2025` Edited by `admin` on `Mon Mar 31 17:48:10 GMT 2025`
Record UNII	1NKX3648J9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DICHLOROBENZYL ALCOHOL

Official Name

English

DYBENAL

Preferred Name

English

Dichlorobenzyl alcohol [WHO-DD]

Common Name

English

DICHLOROBENZYL ALCOHOL [MI]

Common Name

English

DICHLOROBENZYL ALCOHOL [II]

Common Name

English

DICHLOROBENZYL ALCOHOL [MART.]

Common Name

English

OXICONAZOLE RELATED COMPOUND D [USP-RS]

Common Name

English

DICHLOROBENZYL ALCOHOL [VANDF]

Common Name

English

2,4-DICHLOROBENZYL ALCOHOL

Systematic Name

English

RAPIDOSEPT

Brand Name

English

BENZYL ALCOHOL, 2,4-DICHLORO-

Systematic Name

English

NSC-15635

Code

English

2,4-DICHLOROBENZYL ALCOHOL [EP MONOGRAPH]

Common Name

English

2,4-DICHLOROBENZENEMETHANOL

Systematic Name

English

Classification Tree Code System Code

WHO-ATC

R02AA03