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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6Cl2O
Molecular Weight 177.028
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICHLOROBENZYL ALCOHOL

SMILES

OCC1=C(Cl)C=C(Cl)C=C1

InChI

InChIKey=DBHODFSFBXJZNY-UHFFFAOYSA-N
InChI=1S/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2

HIDE SMILES / InChI

Molecular Formula C7H6Cl2O
Molecular Weight 177.028
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dichlorobenzyl alcohol has broad-spectrum activity as an antimicrobial agent and is used in cosmetics and pharmaceuticals. Dichlorobenzyl alcohol has antimicrobial effect against 115 strains of dental plaque. Dichlorobenzyl alcohol inhibited growth of microorganisms but showed highest activity against A. actinomycetemcomitans and Por. gingivalis, organisms related to juvenile and destructive forms of periodontitis. It is a common ingredient in throat lozenges such as Neo angin, Strepsils, Lorsept, and Gorpils. A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and severe acute respiratory syndrome coronavirus (SARS-CoV).

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Neo-angin
Primary
Unknown
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
NEO-Angin. For adults and children over 6 years of age take 1 tablet every 2-3 hours.
Route of Administration: Oral
In Vitro Use Guide
For microbial susceptibility testing dichlorobenzyl alcohol was dissolved in 70% w/v of propylene glycol. It was added to the first medium (see below) by filter sterilization, as a twofold dilution. All strains were anaerobically cultivated in fluid brain-heart infusion (BHI, Difco). Spirochetes were cultivated in BHI supplemented by 15% inactivated rabbit serum, 0.07% Noble agar, and 5 ug/ml of cocarboxylase. Spirochetes were incubated at 37°C for 4 days; all other strains were incubated at 37°C for 2 days. All organisms were approximately equally susceptible to dichlorobenzyl alcohol. The most susceptible strain was the reference strain of A. actinomycetemcomitans, with an MIC of 723 uM. Oral isolates of A. actinomycetemcomitans, C. albicans, Por. gingivalis, and two strains of Tr. socranskii had MIC values of 1,446 uM. MICs for all other strains were 2,892-5,784 uM.
Substance Class Chemical
Record UNII
1NKX3648J9
Record Status Validated (UNII)
Record Version