Nelivaptan is a selective, orally active, non-peptide vasopressin receptor antagonist selective for the V1B subtype. It showed promise in preclinical animal models and advanced to phase II clinical trials for the treatment of anxiety and depression; however, in 2008, Sanofi-Aventis announced that further development of this drug had been halted.

Prodipine (also known as BY-101) is diphenylpiperidines derivative patented by Chemische Fabrik Promonta G.m.b.H. as an anti parkinsonian agent. Prodipine showed monoamine oxidase inhibiting effects in vitro (liver and brain homogenates) similar to those of harmaline. In preclinical studies, Prodipine caused no tachyphylaxis, no increased salivation, or hyperthermia, and had lower toxicity in mice than amphetamine or pemoline. Prodipine decreased reserpine-induced ptosis, antagonized tremorine-induced seizures, and caused only mild hypertension in mice.

Fadolmidine (MPV 2426) is an alpha2-adrenoceptor agonist. Fadolmidine displayed high affinity and full agonist efficacy at all three human alpha2-adrenoceptor subtypes (A, B and C). Various preclinical models of pain have been employed and have demonstrated fadolmidine potential as an analgesic, including its potential for use in neuropathies and post-operative pain. A Phase II clinical trial successfully demonstrated that intrathecal fadolmidine, in combination with bupivacaine, produced analgesic effects compared to bupivacaine alone in bunionectomy patients.

ISONIXIN is an analgesic, antipyretic and non-steroidal anti-inflammatory agent.

ISOCROMIL, a chromone, is an antiallergic agent. It is a mediator release inhibitor used for the treatment of passive cutaneous anaphylaxis and as an anti-asthmatic.

Etofuradine is an antitussive agent.

Ftorpropazine was developed as an antiarrhythmic agent that has never been marketed. Information about the current use of this drug is not available.

Diotyrosine I 131 is the diagnostic aid manufactured by Abbott.

Teflutixol, a thioxanthene derivative was developed as an antipsychotic agent. Information about the current development or use of this compound is not available.

Canbisol is dihydroxyhexahydrodibenzo(b,d)pyran derivative patented by pharmaceutical company Eli Lilly and Co. as antihypertensive agent. At the dosages studied, Canbisol reduced food consumption by rats.