TEFLUTIXOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H26F4N2OS
Molecular Weight	454.524
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCN1CCN(CCCC2C3=CC=C(F)C=C3SC4=CC=C(C=C24)C(F)(F)F)CC1

InChI

InChIKey=BJWAPFORUPUXRJ-UHFFFAOYSA-N

InChI=1S/C23H26F4N2OS/c24-17-4-5-19-18(2-1-7-28-8-10-29(11-9-28)12-13-30)20-14-16(23(25,26)27)3-6-21(20)31-22(19)15-17/h3-6,14-15,18,30H,1-2,7-13H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6140821

Teflutixol, a thioxanthene derivative was developed as an antipsychotic agent. Information about the current development or use of this compound is not available.

Approval Year

PubMed

Title	Date	PubMed
Clonidine sensitizes mice for apomorphine-induced stereotypic gnawing: antagonism by neuroleptics and cholecystokinin-like peptides.	1985-05-20	2862047
Teflutixol (Lu 10-022): a new thioxanthene derivative with antipsychotic properties. A pilot study.	1983-07-01	6140821
Long-term effects of teflutixol on the synthesis and endogenous levels of mouse brain catecholamines.	1975-11	1194924

Patents

Sample Use Guides

In Vivo Use Guide

Teflutixol has been administered for 4 weeks to 21 patients [12 schizophrenics, 6 patients with obsessive, compulsive neurosis (OCN), 2 patients with affective psychosis (AP), and one patient with paranoic reactions (PR)]. The maximum daily dose varied between 0.5 mg and 4 mg administered once in the morning.

Route of Administration: Oral

Name

Type

Language

TEFLUTIXOL

Official Name

English

teflutixol [INN]

Preferred Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710