TEFLUTIXOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H26F4N2OS
Molecular Weight	454.524
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCN1CCN(CCCC2C3=CC=C(F)C=C3SC4=C2C=C(C=C4)C(F)(F)F)CC1

InChI

InChIKey=BJWAPFORUPUXRJ-UHFFFAOYSA-N

InChI=1S/C23H26F4N2OS/c24-17-4-5-19-18(2-1-7-28-8-10-29(11-9-28)12-13-30)20-14-16(23(25,26)27)3-6-21(20)31-22(19)15-17/h3-6,14-15,18,30H,1-2,7-13H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6140821

Teflutixol, a thioxanthene derivative was developed as an antipsychotic agent. Information about the current development or use of this compound is not available.

Approval Year

PubMed

Title	Date	PubMed
Long-term effects of teflutixol on the synthesis and endogenous levels of mouse brain catecholamines.	1975 Nov	1194924
Teflutixol (Lu 10-022): a new thioxanthene derivative with antipsychotic properties. A pilot study.	1983 Jul-Aug	6140821
Clonidine sensitizes mice for apomorphine-induced stereotypic gnawing: antagonism by neuroleptics and cholecystokinin-like peptides.	1985 May 20	2862047

Patents

Sample Use Guides

In Vivo Use Guide

Teflutixol has been administered for 4 weeks to 21 patients [12 schizophrenics, 6 patients with obsessive, compulsive neurosis (OCN), 2 patients with affective psychosis (AP), and one patient with paranoic reactions (PR)]. The maximum daily dose varied between 0.5 mg and 4 mg administered once in the morning.

Route of Administration: Oral

Name

Type

Language

TEFLUTIXOL

Official Name

English

teflutixol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710