U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 651 - 660 of 16236 results

Status:
Investigational
Source:
Vet Res Commun. Jan 2008;32(1):75-92.: Not Applicable Veterinary clinical trial Completed N/A
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

(E)-Tetrachlorovinphos is an (E)- isomer of Tetrachlorovinphos. Tetrachlorovinphos is an organophosphate cholinesterase inhibitor that is used as an insecticide. Tetrachlorvinphos was introduced and first used commercially in 1966 in the USA. Tetrachlorvinphos was originally registered for use on various food crops, livestock, pet animals. Tetrachlorvinphos is applied dermally to livestock to control flies and mites. It is used as an oral larvicide in cattle, hog, goats and horses; in cattle ear tags to control flies; in cattle feedlots; in poultry dust boxes to control poultry mites; and in poultry houses. Tetrachlorvinphos also is used in pet sleeping areas and pet flea collars and to control flies around refuse sites, recreational areas, and for general outdoor treatment. Tetrachlorvinphos can cause cholinesterase inhibition in humans; that is, it can overstimulate the nervous system causing nausea, dizziness, confusion, and at very high exposures (e.g., accidents or major spills), respiratory paralysis and death. In 2014, the Natural Resources Defense Council (NRDC) filed a lawsuit against the United States Environmental Protection Agency (EPA) seeking EPA to respond to NRDC’s 2009 petition to ban tetrachlorvinphos in common pet flea treatment products. Tetrachlorvinphos is reportedly registered for use in Canada, South Africa, and Australia.
Status:
Investigational
Source:
INN:quindecamine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Quindecamine (also known as UCL-1407) is quinaldine derivative with antibiotic and fungicidal activity. Treatment of rats and mice with Quindecamine (250 mg/kg/ day) each day for 4 weeks followed by 500 mg/kg/day for 2 more weeks reduced spontaneous motility and body weight but produced no pathological abnormalities of the various organs studied. In vitro, the drug showed very good activity against Staphylococcus aureus, Streptococcus hemolyticus, Candida albicans, Trichophyton mentagrophytes, and T. vaginalis. The drug had very good activity in 180 human subjects with various bacterial and mycotic diseases of the skin and mucosa when applied as a 1% salve.
Status:
Investigational
Source:
JAN:CALCIUM LINOLEATE [JAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Calcium Linoleate is Calcium salt of linoleic acid with bactericidal activity against Staphylococcus epidermidis(S. epidermidis)in addition to S. aureus and P. acnes. Calcium Linoleate suppliments may have preventive effect on Preeclampsia in nulliparous women
Status:
Investigational
Source:
NCT03059160: Phase 2 Interventional Unknown status Rett Syndrome
(2017)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane. It has been identified as a substrate of phospholipase A2. Saturated fatty acids with carbon chain lengths of C12 to C14 activated the alpha-, beta-, gamma-, and epsilon-subspecies of the protein kinase C, and this activation was synergistic with that by diacylglycerol. Tridecanoic acid(C13) was most effective among the saturated fatty acids examined.
Status:
Investigational
Source:
INN:cetoxime [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cetoxime is an aromatic amine patented by Boots Pure Drug Co. as antihistaminic drug
Status:
Investigational
Source:
INN:pazinaclone
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Isoindoline pazinaclone (also known as DN-2327), a partial agonist at GABAA benzodiazepine receptors, produced anxiolytic, taming and anti-convulsive effects. This neuropsychiatric drug was involved in phase II clinical trial for patients with generalized anxiety disorder. However, this study was discontinued.
Status:
Investigational
Source:
NCT00230581: Phase 2 Interventional Completed Irritable Bowel Syndrome
(2005)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

DDP-225 (also known as MCI-225), a thienopyrimidine analog, is a selective noradrenaline reuptake inhibitor with serotonin receptor antagonism. It shows antidepressant-like properties in animal models. MCI-225 could be useful in the treatment of attentional deficits and related cognitive dysfunctions in psychiatric disorders.
Status:
Investigational
Source:
INN:serazapine
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Serazapine (CGS15040) is an anxiolytic agent. It is structurally novel 5-HT2 receptor antagonist. Preliminary preclinical findings indicated an anticonflict effect in a behavioral suppression test, and two preliminary investigations in volunteers also suggested anxiolytic potential. In the first of these studies serazapine resembled diazepam, a reference anxiolytic drug, electroencephalographically. Additionally, in a test of psychogenic stress in volunteers it reduced cardiac output.
Status:
Investigational
Source:
INN:efepristin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Efepristin (RPR 106972) is an oral streptogramin consisting of two synergistic components RPR 112808 (pristinamycin IB) and RPR 106950 (pristinamycin IIB). It demonstrated activity against Gram-positive microorganisms in vitro and in vivo, including those with multi-drug resistance. The streptogramins inhibit bacterial growth by disrupting the translation of mRNA into protein.
Status:
Investigational
Source:
INN:erbumine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Erbumine (tert-butylamine) is a colorless liquid with an ammonia-like odor. It is used in the preparation of insecticides, pharmaceuticals, oil additives, and rubber accelerators. It neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.