Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H17FN4S |
| Molecular Weight | 328.407 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC2=C(N=C(N=C2S1)N3CCNCC3)C4=CC=CC=C4F
InChI
InChIKey=FVIVKIGLBDRWNR-UHFFFAOYSA-N
InChI=1S/C17H17FN4S/c1-11-10-13-15(12-4-2-3-5-14(12)18)20-17(21-16(13)23-11)22-8-6-19-7-9-22/h2-5,10,19H,6-9H2,1H3
| Molecular Formula | C17H17FN4S |
| Molecular Weight | 328.407 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DDP-225 (also known as MCI-225), a thienopyrimidine analog, is a selective noradrenaline reuptake inhibitor with serotonin receptor antagonism. It shows antidepressant-like properties in animal models. MCI-225 could be useful in the treatment of attentional deficits and related cognitive dysfunctions in psychiatric disorders.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism. | 2001-04 |
|
| Pharmacological profile of the novel antidepressant 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno-[2,3-d]pyrimidine monohydrate hydrochloride. | 1997-12 |
|
| MCI-225, a novel thienopyrimidine analog, enhances attentional eye tracking in midpontine pretrigeminal preparation. | 1997-02 |
|
| Effects of a novel compound MCI-225 on impaired learning and memory in rats. | 1994-06 |
Sample Use Guides
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:18:52 GMT 2025
by
admin
on
Mon Mar 31 19:18:52 GMT 2025
|
| Record UNII |
CU79LWT2HF
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
FDA ORPHAN DRUG |
199704
Created by
admin on Mon Mar 31 19:18:52 GMT 2025 , Edited by admin on Mon Mar 31 19:18:52 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
99487-25-9
Created by
admin on Mon Mar 31 19:18:52 GMT 2025 , Edited by admin on Mon Mar 31 19:18:52 GMT 2025
|
PRIMARY | |||
|
131927
Created by
admin on Mon Mar 31 19:18:52 GMT 2025 , Edited by admin on Mon Mar 31 19:18:52 GMT 2025
|
PRIMARY | |||
|
CU79LWT2HF
Created by
admin on Mon Mar 31 19:18:52 GMT 2025 , Edited by admin on Mon Mar 31 19:18:52 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
SALT/SOLVATE -> PARENT |
