U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 6291 - 6300 of 167129 results

Status:
Investigational
Source:
INN:cloponone [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Cloponone is chloramphenicol derivative with antibacterial activity. It was used in combination with chloramphenicol and myralact for the treatment of trichomonal vaginitis.
Status:
Investigational
Source:
INN:cinepazic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:cinametic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cinnamic acid is an odorless white crystalline acid that has only been recently studied for its potential in cancer prevention. Cinnamic acid and its derivatives are the major group of phenolic acids with ubiquitous distribution in fruits and vegetables. Preclinical data support the beneficial effects of Cinnamic acid, including antioxidant, anti-inflammatory, and anti-cancer activities. A more recent botanical review noted that cinnamic acid may help pre-diabetic and diabetic patients. When infected mice were fed food loaded with cinnamic acid, researchers saw that their insulin levels were better managed. Another study which used mice models saw that cinnamic acid improved glucose tolerance by promoting insulin secretion.
Status:
Investigational
Source:
INN:cinecromen [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Cinecromen is benzopyranone derivative useful as coronary dilators. Cinecromen increases dog coronary blood flow two times after i.v. administration.
Status:
Investigational
Source:
INN:chlordimorine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Chlordimorine is Morpholinoalkyl aryl ether derivative patented by Abbott Laboratories as local anesthetic
Status:
Investigational
Source:
INN:cimepanol [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Cimepanol is cyclohexyl derivative useful as sedatives, cholagogs, and digestion-regulating medicines.
Status:
Investigational
Source:
INN:ceftioxide
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Ceftioxide is broad-spectrum , beta-lactam antibiotic patented by German pharmaceutical company Hoechst A.-G.
Status:
Investigational
Source:
USAN:CEFUROXIME PIVOXETIL [USAN]
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Cefuroxime Pivoxetil is an ester prodrug of cefuroxime, a semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Status:
Investigational
Source:
INN:amitivir
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Amitivir [LY217896], an amino thiadiazole derivative, is an inhibitor of the enzyme inosine monophosphate dehydrogenase. Amitivir has activity against several influenza A and B viruses. Amitivir possesses broad antiviral activity in vitro and in animal models against or thomyxo-and paramyxoviruses. In phase I studies with healthy volunteers, single doses of up to 500 mg were well tolerated and had predictable pharmacokinetics. Oral LY217896 was in trial for prevention of experimental influenza A virus infection and illness in humans. LY217896 was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection. Amitivir development was discontinued.
Status:
Investigational
Source:
INN:amiperone
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Amiperone is a neuroleptic drug. It prolonged the latency (T) and reduced the frequency (F) of the noise escape response rate in rats. It also inhibited lever-press response and reduced the shock-avoidance rate at very low dose levels in rats.

Showing 6291 - 6300 of 167129 results