AMIPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H28ClFN2O2
Molecular Weight	430.943
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)C(=O)C1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C3=CC=C(Cl)C=C3

InChI

InChIKey=WMVSIGOLIQMRHF-UHFFFAOYSA-N

InChI=1S/C24H28ClFN2O2/c1-27(2)23(30)24(19-7-9-20(25)10-8-19)13-16-28(17-14-24)15-3-4-22(29)18-5-11-21(26)12-6-18/h5-12H,3-4,13-17H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C24H28ClFN2O2
Molecular Weight	430.943
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5530581 | https://www.ncbi.nlm.nih.gov/pubmed/5364169

Amiperone is a neuroleptic drug. It prolonged the latency (T) and reduced the frequency (F) of the noise escape response rate in rats. It also inhibited lever-press response and reduced the shock-avoidance rate at very low dose levels in rats.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
The influence of various neuroleptic drugs on noise escape response in rats.	1970	5530581
The influence of various neuroleptic drugs on shock avoidance responding in rats. I. Nondiscriminated Sidman avoidance procedure.	1969	5364169

Patents

Sample Use Guides

In Vivo Use Guide

Rats: 0.01 - 0.31 mg/kg, injected subcutaneously

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:31:47 GMT 2025` Edited by `admin` on `Mon Mar 31 18:31:47 GMT 2025`
Record UNII	FTX5V7543O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMIPERONE

Official Name

English

NSC-170979

Preferred Name

English

4-(P-CHLOROPHENYL)-1-(3-(P-FLUOROBENZOYL)PROPYL)-N,N-DIMETHYLISONIPECOTAMIDE

Common Name

English

amiperone [INN]

Common Name

English

R-2962

Code

English

R 2962

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29710