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Restrict the search for
icosapent ethyl
to a specific field?
Status:
Investigational
Source:
NCT04417621: Phase 2 Interventional Active, not recruiting Melanoma
(2020)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT01803074: Phase 2 Interventional Completed Infection, Human Immunodeficiency Virus
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT02253940: Phase 1 Interventional Completed Healthy
(2006)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT03230318: Phase 2 Interventional Completed Intrahepatic Cholangiocarcinoma
(2017)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Derazantinib (ARQ 087) is an investigational, oral, multi-kinase inhibitor designed to preferentially inhibit the FGFR family of kinases with demonstrated activity in FGFR2 genetic alterations, including fusions. In human cancers, FGFRs have been found to be dysregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications. FGFR dysregulation has been identified as a driver in a number of cancers, including iCCA, cholangiocarcinoma, bladder, endometrial, breast, gastric, lung and ovarian. Current scientific literature suggests FGFR alterations exist in anywhere from 5% to 40% of these cancers. Derazantinib is a potent FGFR inhibitor that shows strong anti-proliferative activity in cell lines harboring FGFR2 alterations. In clinical testing, the molecule has demonstrated activity in cancerous tumors harboring FGFR2 fusions in iCCA and bladder cancers.
Status:
Investigational
Source:
NCT04084860: Phase 2 Interventional Recruiting Alcohol Use Disorder
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT00939211: Phase 2 Interventional Completed Chronic Obstructive Pulmonary Disease
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
AZD9164 was invented by AstraZeneca as a muscarinic M(3) receptor antagonist for evaluation of the potential as a treatment for chronic obstructive pulmonary disease. However, in 2010 studies were discontinued.
Status:
Investigational
Source:
NCT04636801: Phase 3 Interventional Recruiting Chronic Obstructive Pulmonary Disease
(2021)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
CHF6001 is a phosphodiesterase 4 (PDE4) inhibitor optimised for inhaled delivery and tolerability, for the treatment of Asthma and Chronic Obstructive Pulmonary Disease. CHF6001 was 7- and 923-fold more potent than roflumilast and cilomilast, respectively, in inhibiting PDE4 enzymatic activity. CHF6001 inhibited PDE4 isoforms A-D with equal potency, showed an elevated ratio of high-affinity rolipram binding site versus low-affinity rolipram binding site and displayed >20,000-fold selectivity versus PDE4 compared with a panel of phosphodiesterases. CHF6001 effectively inhibited the release of tumor necrosis factor-α from human peripheral blood mononuclear cells, human acute monocytic leukemia cell line macrophages (THP-1), and rodent macrophages (RAW264.7 and NR8383). CHF6001 has the potential to be an effective topical treatment of conditions associated with pulmonary inflammation, including asthma and chronic obstructive pulmonary disease.
Status:
Investigational
Source:
NCT04589845: Phase 2 Interventional Recruiting Solid Tumors
(2021)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Idasanutlin (RG-7388) is a second-generation, orally bioavailable, selective p53-MDM2 antagonist. MDM2 is an important negative regulator of the p 53 tumor suppressor and is expressed at high levels in a large proportion of acute myeloid leukemia (AML). Blocking the MDM2-p53 interaction stabilizes p53 and activates p-53 mediated cell death and inhibition cell growth. Idasanutlin is under clinical trial in phase III for treatment AML and in combinations with others drugs in phase I/II for treatment of multiple myeloma.
Status:
Investigational
Source:
NCT01483924: Phase 2 Interventional Completed Plaque Psoriasis
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Orilotimod (previously known as Apo 805K1), an antipsoriatic agent that was studied for the treatment of moderate to severe plaque psoriasis. This drug successfully completed phase II clinical trial in the USA. However, information about the further development of this drug is not available.
Status:
Investigational
Source:
NCT00482417: Phase 2 Interventional Completed Rheumatoid Arthritis
(2002)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
MK-0359 (L-454560) is a selective and potent type 4 phosphodiesterases (PDE4) inhibitor, which binds to both the apo-(Mg2+-free) and holoenzyme states of PDE4. This compound successfully has passed the phase II clinical trial for the treatment of asthma, Pulmonary Disease, Chronic Obstructive (COPD) and Rheumatoid Arthritis. However, there is no information about the further research of this drug.
