ORILOTIMOD

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H19N3O5
Molecular Weight	333.3392
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@H](CCC(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(O)=O)C(O)=O

InChI

InChIKey=CATMPQFFVNKDEY-DGCLKSJQSA-N

InChI=1S/C16H19N3O5/c17-11(15(21)22)5-6-14(20)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,20)(H,21,22)(H,23,24)/t11-,13-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C16H19N3O5
Molecular Weight	333.3392
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT01483924 | https://adisinsight.springer.com/drugs/800035509

Orilotimod (previously known as Apo 805K1), an antipsoriatic agent that was studied for the treatment of moderate to severe plaque psoriasis. This drug successfully completed phase II clinical trial in the USA. However, information about the further development of this drug is not available.

Originator

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

Cmax for dosages of 10 mg, 30 mg, 60 mg, or 100 mg Apo805K1 (ORILOTIMOD), determined on Day 14

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:04:25 GMT 2025` Edited by `admin` on `Mon Mar 31 23:04:25 GMT 2025`
Record UNII	Q66Z43C5XM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ORILOTIMOD

Official Name

English

THYMODEPRESSIN

Preferred Name

English

APO805

Code

English

Thymodepressin [WHO-DD]

Common Name

English

D-.GAMMA.-GLUTAMYL-D-TRYPTOPHAN

Systematic Name

English

D-TRYPTOPHAN, D-.GAMMA.-GLUTAMYL-

Systematic Name

English

(2R)-2-AMINO-5-(((1R)-1-CARBOXY-2-(1H-INDOL-3-YL)ETHYL)AMINO)-5-OXOPENTANOIC ACID

Systematic Name

English

orilotimod [INN]

Common Name

English

ORILOTIMOD [USAN]

Common Name

English

TIMODEPRESSIN

Common Name

English

APO-805

Code

English

Code System Code Type Description

ChEMBL

CHEMBL3137306