ORILOTIMOD POTASSIUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H17N3O5.K.H
Molecular Weight	371.4295
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H+].[K+].N[C@H](CCC(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C([O-])=O)C([O-])=O

InChI

InChIKey=JBUWHGCMOSDECA-LOCPCMAASA-M

InChI=1S/C16H19N3O5.K/c17-11(15(21)22)5-6-14(20)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12;/h1-4,8,11,13,18H,5-7,17H2,(H,19,20)(H,21,22)(H,23,24);/q;+1/p-1/t11-,13-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H17N3O5
Molecular Weight	331.3233
Charge	-2
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	H
Molecular Weight	1.0079
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT01483924 | https://adisinsight.springer.com/drugs/800035509

Orilotimod (previously known as Apo 805K1), an antipsoriatic agent that was studied for the treatment of moderate to severe plaque psoriasis. This drug successfully completed phase II clinical trial in the USA. However, information about the further development of this drug is not available.

Originator

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

Cmax for dosages of 10 mg, 30 mg, 60 mg, or 100 mg Apo805K1 (ORILOTIMOD), determined on Day 14

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:09:55 GMT 2023` Edited by `admin` on `Sat Dec 16 09:09:55 GMT 2023`
Record UNII	Q8858ZSK4Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ORILOTIMOD POTASSIUM

Official Name

English

APO805K1

Code

English

APO-805K1

Code

English

D-TRYPTOPHAN, D-.GAMMA.-GLUTAMYL-, POTASSIUM SALT (1:1)

Systematic Name

English

ORILOTIMOD POTASSIUM [USAN]

Common Name

English

Code System Code Type Description

FDA UNII

Q8858ZSK4Y