U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C16H19N3O5
Molecular Weight 333.3392
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ORILOTIMOD

SMILES

N[C@H](CCC(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(O)=O)C(O)=O

InChI

InChIKey=CATMPQFFVNKDEY-DGCLKSJQSA-N
InChI=1S/C16H19N3O5/c17-11(15(21)22)5-6-14(20)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,20)(H,21,22)(H,23,24)/t11-,13-/m1/s1

HIDE SMILES / InChI
Orilotimod (previously known as Apo 805K1), an antipsoriatic agent that was studied for the treatment of moderate to severe plaque psoriasis. This drug successfully completed phase II clinical trial in the USA. However, information about the further development of this drug is not available.

Approval Year

Patents

Sample Use Guides

Cmax for dosages of 10 mg, 30 mg, 60 mg, or 100 mg Apo805K1 (ORILOTIMOD), determined on Day 14
Route of Administration: Oral
Name Type Language
ORILOTIMOD
INN   USAN  
USAN   INN  
Official Name English
APO805
Code English
Thymodepressin [WHO-DD]
Common Name English
D-.GAMMA.-GLUTAMYL-D-TRYPTOPHAN
Systematic Name English
D-TRYPTOPHAN, D-.GAMMA.-GLUTAMYL-
Systematic Name English
(2R)-2-AMINO-5-(((1R)-1-CARBOXY-2-(1H-INDOL-3-YL)ETHYL)AMINO)-5-OXOPENTANOIC ACID
Systematic Name English
THYMODEPRESSIN
WHO-DD  
Common Name English
orilotimod [INN]
Common Name English
ORILOTIMOD [USAN]
Common Name English
TIMODEPRESSIN
Common Name English
APO-805
Code English
Code System Code Type Description
ChEMBL
CHEMBL3137306
Created by admin on Sat Dec 16 10:08:19 GMT 2023 , Edited by admin on Sat Dec 16 10:08:19 GMT 2023
PRIMARY
INN
9909
Created by admin on Sat Dec 16 10:08:19 GMT 2023 , Edited by admin on Sat Dec 16 10:08:19 GMT 2023
PRIMARY
SMS_ID
300000034329
Created by admin on Sat Dec 16 10:08:19 GMT 2023 , Edited by admin on Sat Dec 16 10:08:19 GMT 2023
PRIMARY
CAS
186087-26-3
Created by admin on Sat Dec 16 10:08:19 GMT 2023 , Edited by admin on Sat Dec 16 10:08:19 GMT 2023
PRIMARY
FDA UNII
Q66Z43C5XM
Created by admin on Sat Dec 16 10:08:19 GMT 2023 , Edited by admin on Sat Dec 16 10:08:19 GMT 2023
PRIMARY
USAN
AB-03
Created by admin on Sat Dec 16 10:08:19 GMT 2023 , Edited by admin on Sat Dec 16 10:08:19 GMT 2023
PRIMARY
PUBCHEM
7275810
Created by admin on Sat Dec 16 10:08:19 GMT 2023 , Edited by admin on Sat Dec 16 10:08:19 GMT 2023
PRIMARY
NCI_THESAURUS
C174870
Created by admin on Sat Dec 16 10:08:19 GMT 2023 , Edited by admin on Sat Dec 16 10:08:19 GMT 2023
PRIMARY