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Details

Stereochemistry ABSOLUTE
Molecular Formula C29H38FN2O2
Molecular Weight 465.6226
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of AZD-9164

SMILES

C[C@@](N1CCCCC1)(C(=O)O[C@H]2C[N+]4(CCC3=CC=C(F)C=C3)CCC2CC4)C5=CC=CC=C5

InChI

InChIKey=FNYFFCOCVNTJCD-NNMXADRKSA-N
InChI=1S/C29H38FN2O2/c1-29(25-8-4-2-5-9-25,31-17-6-3-7-18-31)28(33)34-27-22-32(20-15-24(27)16-21-32)19-14-23-10-12-26(30)13-11-23/h2,4-5,8-13,24,27H,3,6-7,14-22H2,1H3/q+1/t24?,27-,29-,32?/m0/s1

HIDE SMILES / InChI

Description

AZD9164 was invented by AstraZeneca as a muscarinic M(3) receptor antagonist for evaluation of the potential as a treatment for chronic obstructive pulmonary disease. However, in 2010 studies were discontinued.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
The discovery of AZD9164, a novel muscarinic M3 antagonist.
2011 Dec 15
Long acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs.
2017 Feb

Sample Use Guides

In Vivo Use Guide
Solution for inhalation through nebulization, single dose. AZD9164 solution for inhalation through nebulisation 100 mcg (lung deposited dose) + 1 x placebo for Spiriva dry powder for inhalation
Route of Administration: Other
Name Type Language
AZD-9164
Common Name English
AZD9164
Code English
AZD 9164 [WHO-DD]
Common Name English
J3.232.015E
Code English
1-AZONIABICYCLO(2.2.2)OCTANE, 1-(2-(4-FLUOROPHENYL)ETHYL)-3-((2S)-1-OXO-2-PHENYL-2-(1-PIPERIDINYL)PROPOXY)-, (3R)-
Systematic Name English
1-(4-FLUOROPHENETHYL)-3.BETA.-((S)-2-PHENYL-2-(1-PIPERIDINYL)PROPIONYLOXY)QUINUCLIDINIUM
Systematic Name English
Code System Code Type Description
CAS
1034978-04-5
Created by admin on Sat Dec 16 10:14:06 GMT 2023 , Edited by admin on Sat Dec 16 10:14:06 GMT 2023
PRIMARY
PUBCHEM
44517831
Created by admin on Sat Dec 16 10:14:06 GMT 2023 , Edited by admin on Sat Dec 16 10:14:06 GMT 2023
PRIMARY
FDA UNII
977LWC4O5D
Created by admin on Sat Dec 16 10:14:06 GMT 2023 , Edited by admin on Sat Dec 16 10:14:06 GMT 2023
PRIMARY
DRUG BANK
DB12115
Created by admin on Sat Dec 16 10:14:06 GMT 2023 , Edited by admin on Sat Dec 16 10:14:06 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of AZD-9164
SALT/SOLVATE (PARENT)
Structure of AZD-9164 BROMIDE
NIH
NCATS
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