U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 571 - 580 of 1923 results

Status:
Possibly Marketed Outside US
Source:
LAGEVRIO by Merck Sharp & Dohme LLC
(2021)
Source URL:
First approved in 2021

Class (Stereo):
CHEMICAL (ABSOLUTE)

Dihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers. Like capsaicin, it contributes to the spicy taste of chili peppers, although it is less potent than capsacian. Dihydrocapsaicin has been shown to induce hypothermia in rats, a property which may help protect victims of stroke and cardiac arrest.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Propyperone is acylpiperidine derivative patented by N. V. Research Laboratorium as a neuroleptic agent with mammotropic activity.
Status:
Possibly Marketed Outside US
First approved in 2018

Class (Stereo):
CHEMICAL (ACHIRAL)

Vanadyl sulfate is a trace mineral that is needed in small quantities by your body. It is found in soybeans, mushrooms, shellfish, carrots, oat, cabbage and vegetable oils, such as sunflower, soybean, safflower and olive oil. Like most water-soluble sulfates, vanadyl sulfate is only rarely found in nature. Vanadyl sulfate exhibits insulin-like effects. Vanadyl sulfate is a component of food supplements and experimental drugs. Vanadyl sulfate has been extensively studied in the field of diabetes research as a potential means of increasing insulin sensitivity. No evidence indicates that oral vanadium supplementation improves glycaemic control. Vanadyl sulfate could play an important role in the treatment of metabolic syndrome, contributing to a decrease in obesity and T2DM, through different ways, such as euglycemia, satiety, weight loss, and lipid profile optimization, among others. However, more research is needed to confirm this suggestion.
Status:
Possibly Marketed Outside US
Source:
ANZUWEI by Šorm, F.|Zaoral, M.|Herout, V.
Source URL:
First approved in 2018
Source:
AZULENE FINISHING OIL INGREDIENTS by Coty US LLC
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Guaiazulene is a blue compound. It is a derivative of azulene, guaiazulene is a bicyclic sesquiterpene that is a constituent of some essential oils, mainly oil of guaiac and chamomile oil. Guaiazulene is an U.S. FDA-approved cosmetic color additive. Guaiazulene is used in the formulation of bath products, cleansing products, depilatories, hair bleaches, hair conditioners, hair dyes and colors, hair straighteners, permanent waves, skin care products and skin fresheners. Guaiazulene has antioxidant, antifungal, antimicrobial, anti-inflammatory, anti-spasmodic, anti-ulcer, antitumoral activities and relaxant properties. Common side effects are: diarrhea, constipation, etc.
Status:
Possibly Marketed Outside US
Source:
High Potency Multivitamins & Minerals Caplets by Ashbury Research Corporation [Canada]
Source URL:
First approved in 2015
Source:
Vita-Rx Diabetic Vitamin by MAS Management Group Inc.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

There is no information about pharmacological and biological application of vanadium pentoxide (V2O5). However, inhalation of this substance is a toxic for mammalian and repeated exposures to V2O5 containing particles may augment lung carcinogenesis in susceptible individuals through oxidative stress mediated pathways.
Status:
Possibly Marketed Outside US
Source:
Convenia by Pfizer
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Cefovecin is a third generation cephalosporin with a broad-spectrum of activity against Gram-positive and Gram-negative bacteria. Cefovecin differs from other cephalosporins in that it is highly protein bound and has a long duration of activity. As with all cephalosporins, the bactericidal action of cefovecin results from the inhibition of bacterial cell wall synthesis through binding to the penicillin-binding proteins (PBPs). It is indicated for the treatment of skin infections secondary superficial pyoderma, abscesses and wounds. Some gastrointestinal adverse effects like vomiting, anorexia or diarrhea were observed.