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Details

Stereochemistry ACHIRAL
Molecular Formula C15H18
Molecular Weight 198.3034
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GUAIAZULENE

SMILES

CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1

InChI

InChIKey=FWKQNCXZGNBPFD-UHFFFAOYSA-N
InChI=1S/C15H18/c1-10(2)13-7-5-11(3)14-8-6-12(4)15(14)9-13/h5-10H,1-4H3

HIDE SMILES / InChI

Molecular Formula C15H18
Molecular Weight 198.3034
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Guaiazulene is a blue compound. It is a derivative of azulene, guaiazulene is a bicyclic sesquiterpene that is a constituent of some essential oils, mainly oil of guaiac and chamomile oil. Guaiazulene is an U.S. FDA-approved cosmetic color additive. Guaiazulene is used in the formulation of bath products, cleansing products, depilatories, hair bleaches, hair conditioners, hair dyes and colors, hair straighteners, permanent waves, skin care products and skin fresheners. Guaiazulene has antioxidant, antifungal, antimicrobial, anti-inflammatory, anti-spasmodic, anti-ulcer, antitumoral activities and relaxant properties. Common side effects are: diarrhea, constipation, etc.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
9.8 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ANZUWEI
Primary
ANZUWEI
Primary
Ophthalmo-Azulen
Primary
Ophthalmo-Azulen

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
Take 1 tablet (2 mg of the active ingredient) at a time, three times daily, before meals.
Route of Administration: Other
In Vitro Use Guide
Guaiazulene caused statistically important increases in total oxidative stress levels at concentrations higher than 100 µg/mL in rat neuron cell line.
Substance Class Chemical
Record UNII
2OZ1K9JKQC
Record Status Validated (UNII)
Record Version