Vanadyl sulfate is a trace mineral that is needed in small quantities by your body. It is found in soybeans, mushrooms, shellfish, carrots, oat, cabbage and vegetable oils, such as sunflower, soybean, safflower and olive oil. Like most water-soluble sulfates, vanadyl sulfate is only rarely found in nature. Vanadyl sulfate exhibits insulin-like effects. Vanadyl sulfate is a component of food supplements and experimental drugs. Vanadyl sulfate has been extensively studied in the field of diabetes research as a potential means of increasing insulin sensitivity. No evidence indicates that oral vanadium supplementation improves glycaemic control. Vanadyl sulfate could play an important role in the treatment of metabolic syndrome, contributing to a decrease in obesity and T2DM, through different ways, such as euglycemia, satiety, weight loss, and lipid profile optimization, among others. However, more research is needed to confirm this suggestion.