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Status:
Investigational
Source:
NCT03493698: Phase 1 Interventional Completed Drug Interaction Potentiation
(2018)
Source URL:
Class (Stereo):
CHEMICAL (EPIMERIC)
Status:
Investigational
Source:
NCT02379845: Phase 3 Human clinical trial Completed N/A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
Ter Arkh. 2001;73(10):38-40.: Not Applicable Human clinical trial Completed Hypertension
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT02723669: Phase 1 Interventional Completed Healthy
(2014)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
Br J Clin Pharmacol. Aug 2024;90(8):1975-1983.: Not Applicable Human clinical trial Completed Vitamin B 12 Deficiency/blood
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Methylmalonic acid (MMA) is a C-methylated derivative of malonate. Elevated levels of methylmalonic acid result from inherited defects of enzymes involved in MMA metabolism or inherited or acquired deficiencies of vitamin B12 or its downstream metabolites. MMA is also a specific diagnostic marker for the group of disorders collectively called methylmalonic acidemia.
Status:
Investigational
Source:
NCT01558635: Not Applicable Interventional Terminated Longstanding Persistent Atrial Fibrillation
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT02954042: Not Applicable Interventional Completed Incontinence
(2017)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Chlormethazole (also known as Methazole) is an oxadiazolidine derivative and selective herbicide formerly used in Australia to control weeds in onions.
Status:
Investigational
Source:
NCT03820245: Not Applicable Interventional Completed Oxidative Stress
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
Suppl Clin Neurophysiol. 2006;58:71-84.: Not Applicable Human clinical trial Completed N/A
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Bicuculline is a phthalide-isoquinoline compound that is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. Since it blocks the inhibitory action of GABA receptors, the action of bicuculline mimics epilepsy. This property is utilized in laboratories across the world in the in vitro study of epilepsy, generally in hippocampal or cortical neurons in prepared brain slices from rodents. This compound is also routinely used to isolate glutamatergic (excitatory amino acid) receptor function.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Remacemide is a low-affinity noncompetitive NMDA receptor antagonist with sodium channel blocking properties. It has been studied for a number of conditions including acute ischemic stroke, epilepsy, Parkinsons Disease, and Huntington's disease. It was concluded, that was unlikely that remacemide would be further developed as an antiepileptic drug. As for other conditions, there no any information in the literature, why remacemide is no longer being developed for them.
