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Status:
Investigational
Class (Stereo):
CHEMICAL (MIXED)
Cypenamine (2-phenylcyclopentylamine) is a psychostimulant and antidepressant drug developed at William S. Merrell Chemical Company.
Status:
Investigational
Source:
NCT00677053: Phase 2 Interventional Completed Acute Coronary Syndrome
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Letaxaban is an orally active, tetrahydropyrimidin-2(1H)-one derivative and inhibitor of coagulation factor Xa (activated factor X) with anticoagulant activity. Letaxaban may have anti-inflammatory potential in addition to its anti-thrombotic effects. Letaxaban had been in phase II clinical trials by Takeda for the treatment of venous thromboembolism (VTE). However, this research has been discontinued. Takeda had discontinued their phase II clinical trials for the treatment of acute coronary syndrome (ACS) since the results failed to meet the target efficacy and safety profile.
Status:
Investigational
Source:
Chemioterapia. Jun 1987;6(2 Suppl):706-8.: Not Applicable Human clinical trial Completed Lung Neoplasms/therapy
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
NCT02355028: Phase 2 Interventional Completed Exudative Age-Related Macular Degeneration
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT02308800: Not Applicable Interventional Withdrawn Foot Ulcer, Diabetic
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
JAN:PYRIDAPHENTHION [JAN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Pyridiphenthion (also known as Pyridaphenthion) is dialkyl pyridazinonyl thiophosphate derivative patented by American Cyanamid Co. as insecticides. Pyridiphenthion acts as broad-spectrum insecticide and acaricide used in the control of sucking and chewing insects and spider mites in cereals, vegetables, fruits and ornamental crops. In Spain and in other countries, it is used in rice fields for the control of Chilo supressalis by aerial application and could contaminate Mediterranean wetlands like Albufera Natural Park
Status:
Investigational
Source:
NCT03548298: Not Applicable Interventional Completed Gastro Esophageal Reflux
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT03317587: Not Applicable Interventional Completed Obesity
(2017)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT02661672: Not Applicable Interventional Completed Intracranial Hemorrhage
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT00457574: Phase 1 Interventional Withdrawn Solid Tumors and Lymphomas
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Teglarinad (also known as GMX1777) is a prodrug of GMX1778 and is an inhibitor of nicotinamide phosphoribosyl transferase (NAMPT). It is known that NAMPT involves in NAD(+) biosynthesis, which serves as an important substrate for proteins involved in DNA repair. Teglarinad was evaluated in two human head and neck cancer models in combination with radiotherapy. It was shown that the combining GMX1777 with pemetrexed was an effective new therapeutic strategy to treat nonsquamous non-small cell lung carcinoma (NSCLC). In addition, the drug participated in clinical trial phase I/II in combination with temozolomide for the treatment of metastatic melanoma, however, this study was terminated due to financial constraints.
