U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 41 - 50 of 72 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Alpha-carotene is a provitamin A carotenoid present in fruits and vegetables. Higher serum concentrations of α-carotene have been associated with lower risk of cancer and all-cause mortality. It was suggested that genetic variants influence serum concentrations of provitamin A. Recently was found, that α-carotene effectively inhibits Lewis lung carcinoma (LLC) metastasis and suppresses lung metastasis in combination with taxol in LLC-bearing mice, suggesting that Alpha-carotene could be used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs.
Status:
US Previously Marketed
Source:
Monase by Upjohn
(1961)
Source URL:
First approved in 1961
Source:
Monase by Upjohn
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

ETRYPTAMINE (MONASE®), similar to the hallucinogenic tryptamines, is an inhibitor of monoamine oxidase, introduced for use as an antidepressant. It was withdrawn from the market due to problems with agranulocytosis and other side effects. However, it's activity is still under scientific investigation.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Possibly Marketed Outside US
First approved in 2017
Source:
Regenerating Skin Nectar by Alastin Skincare, Inc.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)



δ-Tocopherol (δ-T) is a chiral organic molecule belonging to the group of tocopherol, that vary in their degree of methylation of the phenol moiety of the chromanol ring. It was revealed, that δ-Tocopherol had a more potent anticancer activity in solid tumors compared to the other tocopherols, δ-T possessed antileukemic activity of in acute myeloid leukemia (AML). δ-T induced tumor cell death through peroxisome proliferator-activated receptor γ (PPAR-γ) induction, cyclin-D1 inhibition, and modulation of redox balance. In addition, on animal models was found, that δ-tocopherol was more active than α- or γ-tocopherol in inhibiting lung tumor growth, possibly through trapping reactive oxygen and nitrogen species and inducing apoptosis.

Showing 41 - 50 of 72 results