Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C12H16N2 |
| Molecular Weight | 188.2688 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(N)CC1=CNC2=CC=CC=C12
InChI
InChIKey=ZXUMUPVQYAFTLF-UHFFFAOYSA-N
InChI=1S/C12H16N2/c1-2-10(13)7-9-8-14-12-6-4-3-5-11(9)12/h3-6,8,10,14H,2,7,13H2,1H3
ETRYPTAMINE (MONASE®), similar to the hallucinogenic tryptamines, is an inhibitor of monoamine oxidase, introduced for use as an antidepressant. It was withdrawn from the market due to problems with agranulocytosis and other side effects. However, it's activity is still under scientific investigation.
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
Sources: https://patents.google.com/patent/US3296072 https://books.google.ru/books?id=l1DrqgobbcwC&pg=PA102&lpg=PA102&dq=Monase retrieved from Hallucinogens: A Forensic Drug Handbook: Richard R. Laing, Barry L. Beyerstein, Jay A. Siegel, p.102 https://www.ncbi.nlm.nih.gov/pubmed/13685431 https://www.ncbi.nlm.nih.gov/pubmed/13765760 |
Primary | Monase Approved UseDepression Launch Date-2.83996815E11 |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
8.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8099943/ |
single, oral |
ETRYPTAMINE plasma | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
50 mg 1 times / day multiple, oral Highest studied dose Dose: 50 mg, 1 times / day Route: oral Route: multiple Dose: 50 mg, 1 times / day Sources: |
unhealthy, 61-93 years n = 5 Health Status: unhealthy Condition: depression Age Group: 61-93 years Sex: M+F Population Size: 5 Sources: |
Other AEs: Palpitation, Nervousness... Other AEs: Palpitation (3 patients) Sources: Nervousness (3 patients) |
30 mg 1 times / day multiple, oral Studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, 61-93 years n = 24 Health Status: unhealthy Condition: depression Age Group: 61-93 years Sex: M+F Population Size: 24 Sources: |
Other AEs: Palpitation, Nervousness... Other AEs: Palpitation (4 patients) Sources: Nervousness (4 patients) |
700 mg single, oral Overdose |
unknown n = 1 |
Other AEs: Malignant hyperthermia... Other AEs: Malignant hyperthermia (grade 5, 1 patient) Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Nervousness | 3 patients | 50 mg 1 times / day multiple, oral Highest studied dose Dose: 50 mg, 1 times / day Route: oral Route: multiple Dose: 50 mg, 1 times / day Sources: |
unhealthy, 61-93 years n = 5 Health Status: unhealthy Condition: depression Age Group: 61-93 years Sex: M+F Population Size: 5 Sources: |
| Palpitation | 3 patients | 50 mg 1 times / day multiple, oral Highest studied dose Dose: 50 mg, 1 times / day Route: oral Route: multiple Dose: 50 mg, 1 times / day Sources: |
unhealthy, 61-93 years n = 5 Health Status: unhealthy Condition: depression Age Group: 61-93 years Sex: M+F Population Size: 5 Sources: |
| Nervousness | 4 patients | 30 mg 1 times / day multiple, oral Studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, 61-93 years n = 24 Health Status: unhealthy Condition: depression Age Group: 61-93 years Sex: M+F Population Size: 24 Sources: |
| Palpitation | 4 patients | 30 mg 1 times / day multiple, oral Studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, 61-93 years n = 24 Health Status: unhealthy Condition: depression Age Group: 61-93 years Sex: M+F Population Size: 24 Sources: |
| Malignant hyperthermia | grade 5, 1 patient | 700 mg single, oral Overdose |
unknown n = 1 |
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| Classification Tree | Code System | Code | ||
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WIKIPEDIA |
TiHKAL
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DEA NO. |
7249
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WIKIPEDIA |
Designer-drugs-Monase
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NCI_THESAURUS |
C667
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| Code System | Code | Type | Description | ||
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1117
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DB01546
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100000082116
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SUB07347MIG
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CHEMBL1619758
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1276
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alpha-Ethyltryptamine
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PRIMARY | α-Ethyltryptamine (αET, AET), also known as etryptamine (INN, BAN, USAN), is a psychedelic, stimulant, and entactogenic drug of the tryptamine class. It was originally developed and marketed as an antidepressant under the brand name Monase by Upjohn in the 1960s. αET is structurally and pharmacologically related to αMT, α-methyltryptamine, and it is believed[4] its central stimulant activity is probably not due to its activity as an MAOI, but appears to stem from its structural relationship to the indolic psychedelics. In contrast to αMT, αET is less stimulating and hallucinogenic, its effects resembling more those of entactogens like MDMA ("Ecstasy"). | ||
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C72772
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m727
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C038034
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2235-90-7
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GR181O3R32
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8367
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DTXSID1046764
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PE 006
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
