{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
Restrict the search for
estrone
to a specific field?
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase. Estrogens enter the cells of responsive tissues (e.g. female organs, breasts, hypothalamus, pituitary) where they interact with estrogen receptors. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) release from the anterior pituitary. (-)-Estrone (ent-Estrone) is an ent-steroid which is devoid of hormonal activity. ent-Estrone or ent-estradiol is obtained analogously to the natural hormones from ent-estradiol-3-methyl ether that is produced totally synthetically by oxidation, ether cleavage and reduction. (+)-Estrone is a sexual hormone and (-)-Estrone is inactive.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
There is no available information about this compound
Status:
US Approved Rx
(1977)
Source:
ANDA084951
(1977)
Source URL:
First approved in 1966
Source:
MENRIUM 5-2 by ROCHE
Source URL:
Class:
MIXTURE
Status:
US Approved Rx
(2003)
Source:
NDA021417
(2003)
Source URL:
First approved in 1942
Source:
NDA004782
Source URL:
Class:
MIXTURE
Status:
US Previously Marketed
Source:
ENJUVIA by DURAMED
(2004)
Source URL:
First approved in 2004
Source:
ENJUVIA by DURAMED
Source URL:
Class:
MIXTURE
Status:
US Previously Marketed
Source:
CENESTIN by ASPEN
(1999)
Source URL:
First approved in 1999
Source:
CENESTIN by ASPEN
Source URL:
Class:
MIXTURE
