U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 39221 - 39230 of 39585 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Iodine-labeled ioglycamic acid (Bilivistan or Biligram) has been used as a contrast medium for intravenous cholangiocystography.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Ioglicinate, contrast agent, is used in computed tomography.
Lisuride (DOPERGIN®), a highly active dopaminergic ergot derivative with prolactin-lowering properties, has a pronounced affinity for dopamine receptors. It may also act as an agonist at some serotonin receptors. Lisuride (DOPERGIN®) is concentrated within the pituitary where it acts on dopamine receptors which inhibit prolactin release. It can be used in the clinical conditions where a dopaminergic or prolactin-lowering effect is needed.
Status:
Discontinued
Source:
NDA018107
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Discontinued
Source:
NDA018107
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Withdrawn

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Pangamic acid (6-O-(dimethylaminoacetyl)-D-gluconic acid) has been detected 1938 and described as a natural, universally occurring substance with multiple biological and medical functions. In this respect pangamic acid has been worldwide on the market since decades as a drug stimulating cellular respiration. In addition to the natural pangamic acid, diisopropylammonium dichloroacetate (DIPA), a synthetic product not found in biological material, is on the market requesting similar biological functions. Pangamic acid is the name given to a product originally claimed to contain D-gluconodimethyl aminoacetic acid, which was obtained from apricot kernels and later from rice bran. It is also referred to as vitamin B15, but pangamic acid is not generally recognized as a vitamin. Despite serious safety concerns, pangamic acid is used for improving exercise endurance; treating asthma and related diseases, skin conditions including eczema, lung problems, painful nerve and joint conditions, cancer, and arthritis; improving the oxygenation of the heart, brain, and other vital organs; and “detoxifying” the body. It is also used for treating alcoholism, hangovers, and fatigue; protecting against urban air pollutants; extending cell life; strengthening the immune system; lowering bloodcholesterol levels; and assisting in hormone regulation. Since there is no standard identity for the chemicals in pangamic acid, how it might work is unknown. Although pangamic acid is also called vitamin B15, there is no research that shows it is required by the body, as the term “vitamin” would suggest. The United States Food and Drug Administration has recommended seizing any chemicals advertised as pangamic acid and restraining the importation and interstate shipment of pangamic acid on the grounds that pangamic acid and pangamic acid products are unsafe for use and have no known nutritional properties
mixture
Status:
First approved in 1997
Source:
NaturVet ArthriSoothe by The Garmon Corporation
Source URL:

Class:
MIXTURE

Cefprozil is a 2nd generation cephalosporin that is FDA approved for the treatment of mild to moderate infections of upper respiratory tract, lower respiratory tract, and uncomplicated skin and skin-structure infections. Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Common adverse reactions include diarrhea, nausea, vomiting, dizziness, abdominal pain and vaginitis. Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics. Concomitant administration of probenecid doubled the AUC for cefprozil.
mixture
Status:
First marketed in 1921
Source:
Sodium Glycerophosphate U.S.P.
Source URL:

Class:
MIXTURE



Synthetic glycerophosphates have been known for many years and have been prepared in several ways. The acid may exist in two isomeric forms, alpha and beta. The L-a-acid is the naturally occurring form; the b-acid, present in hydrolyzates of lecithins from natural sources, arises from migration of the phosphoryl group from the a-carbon atom. Dehydrogenation of L-glycerol 3-phosphate produces Dihydroxyacetone phosphate and is part of the entry of glycerol (sourced from triglycerides) into the glycolytic pathway.

Showing 39221 - 39230 of 39585 results